HUMAN M-CSF
Description Source Background- Product Name
- HUMAN M-CSF
- CAS No.
- 81627-83-0
- Chemical Name
- HUMAN M-CSF
- Synonyms
- Csfm;csf-1;M-CSF;MGI-IM;mCSF-1;mM-CSF;RHM-CSF;MGC31930;M-CSF rat;Lanimostim
- CBNumber
- CB5201242
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN M-CSF Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white to off-white
- biological source
- rat
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-26
- WGK Germany
- 3
- RTECS
- GI5500000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- WH0001435M1
- Product name
- Monoclonal Anti-CSF1 antibody produced in mouse
- Purity
- clone 1A9, purified immunoglobulin, buffered aqueous solution
- Packaging
- 100μg
- Price
- $406
- Updated
- 2025/07/31
- Product number
- SRP3332
- Product name
- M-CSF rat
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
- Packaging
- 10μg
- Price
- $432
- Updated
- 2025/07/31
- Product number
- SRP3221
- Product name
- M-CSF from mouse
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μG
- Price
- $259
- Updated
- 2025/07/31
- Product number
- SRP3110
- Product name
- M-CSF human
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μg
- Price
- $259
- Updated
- 2025/07/31
- Product number
- M9170
- Product name
- Macrophage Colony-Stimulating Factor from mouse
- Purity
- M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
- Packaging
- 10μg
- Price
- $225
- Updated
- 2025/07/31
HUMAN M-CSF Chemical Properties,Usage,Production
Uses
Antineoplastic; anti-infective growth factor that acts on both progenitor and mature cells of the macrophage line.
Uses
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
General Description
M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Biochem/physiol Actions
M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer.
Description
Macrophage Colony Stimulating Factor Human Recombinant produced in E.coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 37.1 KD. MCSF is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
HUMAN M-CSF Preparation Products And Raw materials
Raw materials
Preparation Products
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