3-N-Boc-Aminomethylpiperidine

Product Name: 3-N-Boc-Aminomethylpiperidine
CAS No.: 142643-29-6
Chemical Name: 3-N-Boc-Aminomethylpiperidine
Synonyms: TERT-BUTYL PIPERIDIN-3-YLCARBAMATE;PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;3-BOC-AMINOPIPERIDINE;3-BOC-3-AMINOPIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE;3-N-BOC-AMINOMETHYL PIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE 98%;(±)-3-(Boc-aminomethyl)piperidine;3-AMINOPIPERIDINE, 3-BOC PROTECTED;(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
CBNumber: CB5205644
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 142643-29-6.mol

More

Less

3-N-Boc-Aminomethylpiperidine Property

Melting point:: 60-70 °C(lit.)
Boiling point:: 321.8±15.0 °C(Predicted)
Density: 0.981
storage temp.: 2-8°C
form: solid
pka: 12.71±0.46(Predicted)
color: White
BRN: 7023643
CAS DataBase Reference: 142643-29-6(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: C,Xi
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3259 8/PG 2
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 653896
Product name: 3-(Boc-aminomethyl)piperidine
Purity: 95%
Packaging: 1g
Price: $95
Updated: 2023/06/20

Sigma-Aldrich

Product number: 653896
Product name: 3-(Boc-aminomethyl)piperidine
Purity: 95%
Packaging: 10g
Price: $248
Updated: 2025/07/31

TRC

Product number: B630105
Product name: 3-N-Boc-aminomethylPiperidine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB115305
Product name: tert-Butyl piperidin-3-ylmethylcarbamate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: U458
Product name: 3-N-Boc-aminomethylpiperidine
Packaging: 1g
Price: $97
Updated: 2021/12/16

More

Less

3-N-Boc-Aminomethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Reagent for:

Preparation of 9-substituted phenanthrene-based tylophorine analogs
Enzymatic acylation

Uses

Reagent for:
Preparation of Tylophorine analogs
Enzymatic acylation

Synthesis

220031-61-8

142643-29-6

To a solution of tert-butyl (1-benzylpiperidin-3-yl)methylcarbamate (2.05 g, 6.74 mmol, 1.0 equiv) in methanol (40 mL) was added 10% Pd(OH)2/C (0.21 g, 10 wt%). Cyclohexene (6.80 mL, 67.40 mmol, 10.0 eq.) was added to the reaction system under argon protection. The resulting suspension was refluxed under argon atmosphere for 20 hours. Upon completion of the reaction, it was filtered through a Celite pad (Celite 577 fine) and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of dichloromethane/methanol/triethylamine (3:1:0.1, v/v/v) to afford 1.31 g of the target compound 3-Boc-aminomethylpiperidine as a colorless viscous oil. Yield: 91%; Thin Layer Chromatography Rf = 0.33 (dichloromethane/methanol/triethylamine = 3:1:0.1); 1H NMR (400 MHz, CDCl3) δ: 1.08 (qd, J = 11.2, 4.0 Hz, 1H, CH2CHAHBCH), 1.42 (s, 9H, 3 x CH3), 1.45-1.52 (m, 1H. CHAHBCH2CH), 1.58-1.70 (m, 2H, CHAHBCHAHBCH), 1.76-1.82 (m, 1H, CH), 2.32 (t, J = 11.2 Hz, 1H, NHCHAHBCH), 2.52-2.60 (m, 2H, CH2CHAHBNH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCO 3H, CH2NHCO + CH2CHAHBNH), 3.06 (dd, J = 11.6, 3.2 Hz, 1H, NHCHAHBCH), 4.63 (br s, 1H, NHCO); 13C NMR (100 MHz, CDCl3) δ: 24.99, 27.97, 28.27, 36.86, 43.74, 45.90, 49.54, 78.28, 155.86; ESI-HRMS m/z calculated C11H23N2O2 [M+H]+ 215.1760, measured 215.1763; IR (KBr) υ: 3385, 2978, 2934, 1685, 1528, 1458, 1367, 1272, 1254, 1174, 1009 cm-1 1174, 1009 cm-1.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4442 - 4452
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 633 - 645
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139

3-N-Boc-Aminomethylpiperidine Preparation Products And Raw materials

Raw materials

L-Glutamic acid dimethyl ester hydrochloride acetonitrile Hexane Ammonium hydroxide Ethanol Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate Sodium borohydride Triethylamine Methanesulfonyl chloride 1,4-Dioxane Ethyl acetate Sodium bicarbonate Dichloromethane Magnesium sulfate Citric acid

Preparation Products

More

Less

3-N-Boc-Aminomethylpiperidine Suppliers

Canada 1 China 107 Europe 1 France 2 Germany 3 India 2 Switzerland 2 Ukraine 1 United Kingdom 9 United States 32 Global 160

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Proactive Molecular Research

Tel: --
Fax: --
Email: tony@proactivemr.com
Country: United States
ProdList: 895
Advantage: 0

Small Molecules, Inc.

Tel: --
Fax: --
Email: sales@small-molecules.com
Country: United States
ProdList: 990
Advantage: 50

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

AstaTech, Inc

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 6371
Advantage: 58

Amber MolTech LLC.

Tel: --
Fax: --
Email: Info@ambermoltech.com
Country: United States
ProdList: 58
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ASDI Incorporated

Tel: --
Fax: --
Email: customerservice@asdi.net
Country: United States
ProdList: 6922
Advantage: 67

Rintech, Inc.

Tel: --
Fax: --
Email: info@rintechinc.com
Country: United States
ProdList: 3416
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

Biofine International Inc.

Tel: --
Fax: --
Email: sales@biofineintl.com
Country: United States
ProdList: 653
Advantage: 38

AQCHEM, LLC

Tel: --
Fax: --
Email: sales@aqchem.com
Country: United States
ProdList: 491
Advantage: 43

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Small Molecules, Inc.

Tel: --
Fax: --
Email: sales@small-molecules.com
Country: United States
ProdList: 1218
Advantage: 30

Milestone PharmTech LLC

Tel: --
Fax: --
Email: sales@milestonepharmtech.com
Country: United States
ProdList: 1316
Advantage: 47

EJY Tech, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 448
Advantage: 30

Atlantic SciTech Group, Inc.

Tel: --
Fax: --
Email: sales@astginc.com
Country: United States
ProdList: 2308
Advantage: 43

More

Less

View Lastest Price from 3-N-Boc-Aminomethylpiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-N-Boc-Aminomethylpiperidine 142643-29-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Career Henan Chemical Co

Product: 3-N-Boc-Aminomethylpiperidine 142643-29-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

142643-29-6, 3-N-Boc-AminomethylpiperidineRelated Search:

4-(Aminomethyl)piperidine 2,2,6,6-Tetramethyl-4-piperidinol 2-PIPERIDYLMETHYLAMINE Haloperidol Cyhalofop-butyl Buprofezin 2-Butoxyethanol TRIMETHYLPHOSPHINE OXIDE Butyl acetate Diethylene glycol monobutyl ether tert-Butyl peroxyacetate Chlorpropham tert-Butyl acetate tert-Butanol 2-(Boc-aminomethyl)-piperidine 4-(Boc-Aminomethyl)piperidine Butyl acrylate 2-Boc-aminomethylpyrrolidine

3-N-BOC-AMINOMETHYL PIPERIDINE

1,1-diMethylethyl [(piperidin-3-yl)-Methyl]carbaMate

tert-Butyl [(piperidin-3-yl)methyl]carbamate, 3-{[(tert-Butoxycarbonyl)amino]methyl}piperidine

(3-Piperidinylmethyl)-carbamic acid 1,1-dimethylethyl ester

Carbamic acid, N-(3-piperidinylmethyl)-, 1,1-dimethylethyl ester

(+/-)-3-(Boc-aminomethyl)piperidine >=98.0% (TLC)

tert-butyl N-(piperidin-3-ylmethyl)carbamate

3-AMINOPIPERIDINE, 3-BOC PROTECTED

(3-AMINOMETHYL, N-BOC PROTECTED)PIPERIDINE

(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE

3-BOC-AMINOMETHYL PIPERIDINE

3-BOC-AMINOPIPERIDINE

TERT-BUTYL (PIPERIDIN-3-YLMETHYL) CARBAMATE

TERT-BUTYL N-(3-PIPERIDYLMETHYL)CARBAMATE

TERT-BUTYL PIPERIDIN-3-YLCARBAMATE

(S)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

(R,S)-(BOC-3-AMINOMETHYL)-PIPERIDINE

(R)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER

3-Aminopiperidine, 3-BOC protected 97%

3-BOC-3-AMINOPIPERIDINE

3-BOC-AMINOMETHYL PIPERIDINE 98%

(Piperidin-3-ylmethyl) carbamic acid tert-butyl ester, tert-Butyl (piperidin-3-ylmethyl) carbamate

3-(Aminomethyl)piperidine, 3-BOC protected

tert-butyl (piperidin-3-ylmethyl)carbamate(SALTDATA: FREE)

(R,S)-3-(Boc-aminomethyl)-piperidine

N-[(3S)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Carbamic acid, (3-piperidinylmethyl)-, 1,1-dimethylethyl ester

(^+)-3-(Boc-aminomethyl)piperidine,98%

(±)-3-(Boc-aminomethyl)piperidine

(±)-3-(Boc-aminomethyl)piperidine, CAS 142643-29-6

3-(Boc-aminomethyl)piperidine - [A12322]

142643-29-6

142643-23-6

C5H10NCH2NHCO2C4H9

Piperidines

Heterocyclic Building Blocks

Building Blocks

pharmacetical

Amines

Pyrans, Piperidines &Piperazines

Piperidine

API intermediates

Pyrans, Piperidines & Piperazines