ChemicalBook > CAS DataBase List > Zoledronic acid hydrate

Zoledronic acid hydrate

Product Name
Zoledronic acid hydrate
CAS No.
165800-06-6
Chemical Name
Zoledronic acid hydrate
Synonyms
ZOLEDRONIC ACID MONOHYDRATE;ZoL;Acid, the;oledronic acid;Zoledronic Acid H2O;ZOL 446 monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;zoledronic acid hydrate;Zoledronate monohydrate
CBNumber
CB5211391
Molecular Formula
C5H12N2O8P2
Formula Weight
290.1
MOL File
165800-06-6.mol
More
Less

Zoledronic acid hydrate Property

Melting point:
245 °C(dec.)
storage temp. 
2-8°C
solubility 
H2O: ≥2mg/mL
form 
powder
color 
white to beige
Merck 
14,10187
InChIKey
FUXFIVRTGHOMSO-UHFFFAOYSA-N
CAS DataBase Reference
165800-06-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
SZ8562450
HS Code 
29332900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0223
Product name
Zoledronic acid monohydrate
Purity
≥98% (HPLC)
Packaging
10mg
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
1724827
Product name
Zoledronic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
Z0031
Product name
Zoledronic Acid Monohydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$122
Updated
2024/03/01
TCI Chemical
Product number
Z0031
Product name
Zoledronic Acid Monohydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$410
Updated
2024/03/01
Cayman Chemical
Product number
14984
Product name
Zoledronic Acid (hydrate)
Purity
≥95%
Packaging
25mg
Price
$68
Updated
2024/03/01
More
Less

Zoledronic acid hydrate Chemical Properties,Usage,Production

Uses

A highly potent bisphosphonate and activator of PKC.

Uses

Zoledronic acid monohydrate is an anti-resorptive agent for cancer bone metasis, also used on studies in the environmental risk asseessment of drugs from view of excretion form to environment.

brand name

Zometa (Novartis).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biological Activity

Zoledronic acid (Zoledronate, CGP-4244) monohydrate is the monohydrate of Zoledronic acid (Zoledronic acid), a potent osteoclast inhibitor that inhibits small GTP-binding proteins by inhibiting enzymes of the mevalonate pathway Such as the prenylation of Ras and Rho to induce osteoclast apoptosis.

Biochem/physiol Actions

Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.

in vitro

Zoledronic Acid monohydrate (0.1-1 μM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) induces apoptosis in MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 4 days) inhibits cell viability due to the induction of apoptosis.Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 μM.

in vivo

Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.

Zoledronic acid hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Zoledronic acid hydrate Suppliers

Shandong Platinum Pharmaceutical Co., Ltd.
Tel
0531- 88963280 18396830603
Fax
0531-88964879
Email
sales@boyuanpharm.com
Country
China
ProdList
230
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9511
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19182
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Shenzhen Pharma Technology Co., Ltd.
Tel
0755-86648230
Fax
0755-86648231
Email
pharma08@sina.com
Country
China
ProdList
166
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5796
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Jinan Kaypharm Chemical Co.,Ltd.
Tel
0531-86986780 13153183025
Fax
0531-86986781
Email
sales@kaypharm.cn
Country
China
ProdList
105
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Watson Biotechnology Co.,Ltd
Tel
027-59207879 1972026995 18140587686
Fax
QQ:1972026995
Email
sales@3600chem.com
Country
China
ProdList
4658
Advantage
55
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Jinan Yuantai Pharmaceutical Co.,Ltd
Tel
0531-69959492 15966603228
Fax
0531-69959492
Email
85633700@qq.com
Country
China
ProdList
79
Advantage
55
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-87157530-8007 13868066926
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
2190
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9994
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Shenzhen Simeiquan Biotechnology Co. Ltd
Tel
18126413629 0755-23311925 2355327053
Fax
0755-23311925
Email
abel@ycgmp.com
Country
China
ProdList
5113
Advantage
58
Jinan Yuantai Pharmaceutical Co.,Ltd
Tel
0531-69959492 18560053868
Fax
0531-88603458
Email
85349064@qq.com
Country
China
ProdList
149
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1985
Advantage
55
More
Less

View Lastest Price from Zoledronic acid hydrate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Zoledronic Acid Monohydrate 165800-06-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-11
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Zoledronic acid hydrate 165800-06-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Zoledronic acid hydrate 165800-06-6
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
99.7%min
Supply Ability
50KG
Release date
2021-07-20

165800-06-6, Zoledronic acid hydrateRelated Search:


  • [1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACID MONOHYDRATE
  • (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid hydrate
  • (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid monohydrate
  • PHOSPHONIC ACID, [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE]BIS-, MONOHYDRATE
  • zoledronic acid hydrate
  • ZOLEDRONIC ACID MONOHYDRATE
  • ZoledronicacidforInjection
  • [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
  • P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate
  • Zoledronate monohydrate
  • [1-hydroxy-2-(1H-iMidazol-1-yl)-ethylidene]bisphosphonic acid Monohydrate
  • (1-Hydroxy-2-(1H-iMidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate
  • Zoledronic acid monohydrate, >=99%
  • oledronic acid
  • Phosphonic acid,P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
  • 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphos
  • Zoledronic acid monohydrate, 98%, Bone resorption inhibitor
  • Acid, the
  • Zoledronic acid (CGP 42446) monohydrate
  • Zoledronic Acid H2O
  • CGP 42446 monohydrate
  • CGP42446A monohydrate
  • ZOL 446 monohydrate
  • edronic acid monohydrate
  • ZoL
  • 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid
  • Zoledronic acid monohydrate DISCONTINUED. Please see Z623501 or Z623505.
  • Zoledronic acid injection
  • P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid
  • Zoledronic acid hydrate (CGP 42446)
  • Zoledronic acid monohydrateQ: What is Zoledronic acid monohydrate Q: What is the CAS Number of Zoledronic acid monohydrate Q: What is the storage condition of Zoledronic acid monohydrate Q: What are the applications of Zoledronic acid monohydrate
  • OLEDRONIC ACID MONOHYDRATE
  • Zoledronic Acid Monohydrate, ≥ 98.0%
  • Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
  • 165800-06-6
  • C5H12N2O8P2
  • Other APIs
  • Smad
  • TGF-beta
  • 11