Fmoc-L-hydroxyproline

Product Name: Fmoc-L-hydroxyproline
CAS No.: 88050-17-3
Chemical Name: Fmoc-L-hydroxyproline
Synonyms: G1-15;FMoc-Hyp;FMOC-HYP-OH;FMOC-L-HYP-OH;FMOC-HYP-OH 99%MIN;RARECHEM EM WB 0137;FMOC-HYP-OH (TRANS);FMOC-HYDROXYPROLINE;FMOC-TRANS-4-HYP-OH;FMOC-L-HYDROXYPROLINE
CBNumber: CB5230512
Molecular Formula: C20H19NO5
Formula Weight: 353.37
MOL File: 88050-17-3.mol

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Fmoc-L-hydroxyproline Property

Melting point:: 189-193 °C
Boiling point:: 595.5±50.0 °C(Predicted)
Density: 1.407±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.74±0.40(Predicted)
color: White to off-white
optical activity: [α]20/D 60±2°, c = 1% in methanol
BRN: 4574378
InChI: InChI=1S/C20H19NO5/c22-12-9-18(19(23)24)21(10-12)20(25)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18,22H,9-11H2,(H,23,24)/t12-,18+/m1/s1
InChIKey: GOUUPUICWUFXPM-XIKOKIGWSA-N
SMILES: N1(C(OCC2C3=C(C=CC=C3)C3=C2C=CC=C3)=O)C[C@H](O)C[C@H]1C(O)=O
CAS DataBase Reference: 88050-17-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52033
Product name: Fmoc-Hyp-OH
Purity: Novabiochem?
Packaging: 5G
Price: $93.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52033
Product name: Fmoc-Hyp-OH
Purity: Novabiochem?
Packaging: 25g
Price: $372
Updated: 2025/07/31

Sigma-Aldrich

Product number: 47686
Product name: Fmoc-Hyp-OH
Purity: ≥98.0% (sum of enantiomers, HPLC)
Packaging: 5g
Price: $71.1
Updated: 2025/07/31

TCI Chemical

Product number: F0899
Product name: Fmoc-Hyp-OH
Packaging: 5G
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: F0899
Product name: Fmoc-Hyp-OH
Packaging: 25G
Price: $122
Updated: 2025/07/31

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Fmoc-L-hydroxyproline Chemical Properties,Usage,Production

Chemical Properties

Light brown solid

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

28920-43-6

51-35-4

88050-17-3

The general procedure for the synthesis of Fmoc-L-hydroxyproline from methyl 9-fluorenyl chloroformate and L-hydroxyproline is as follows: Example 2: Synthesis of (2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid 1. Sodium bicarbonate (80 g) and water (400 ml) were added to a solution of tetrahydrofuran (THF, 200 ml) containing (2S,4R)-4-hydroxy-L-proline (100 g) at 25-30 °C. 2. A solution of 9-fluorenylmethoxycarbonyl (Fmoc) chloride (226 g) dissolved in 200 ml of THF was added slowly. 3. The reaction mixture was stirred continuously at 25-30°C for 10-12 hours until the reaction was complete. 4. Upon completion of the reaction, the reaction was terminated by the addition of an appropriate amount of water. 5. The reaction mixture was washed with diisopropyl ether (DIPE) and subsequently acidified with 1N hydrochloric acid. 6. The acidified mixture was continued to be stirred for 2-3 hours to promote precipitation of the product. 7. The solid product was collected by filtration to give 150 g of Fmoc-L-hydroxyproline as a white solid. Product Characterization: 1H NMR (300 MHz, DMSO-d6): δ 1.89-2.24 (m, 2H), 3.34-3.43 (m, 2H), 3.43-3.54 (m, 0.5H), 4.12-4.21 (m, 3H), 4.25 (s, 2H), 4.28-4.42 (m, 0.5H), 5.16 (brs, 1H) , 7.29-7.34 (m, 2H), 7.38-7.65 (m, 2H), 7.63-7.65 (m, 2H). Melting point: 188-190°C. Mass spectrum (M + H): 354.33.

References

[1] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9509 - 9512
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 10, p. 1784 - 1787
[3] Patent: US9518048, 2016, B2. Location in patent: Page/Page column 24

Fmoc-L-hydroxyproline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-L-hydroxyproline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fmoc-L-Hyp-OH 88050-17-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-26

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Hyp-OH 88050-17-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-07

Career Henan Chemical Co

Product: Fmoc-L-hydroxyproline 88050-17-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

88050-17-3, Fmoc-L-hydroxyprolineRelated Search:

cis-4-Hydroxy-L-proline L-Hydroxyproline N-Vinyl-2-pyrrolidone Fmoc-Phe-OH D-Proline Pyrrolidine Fmoc-Lys(Boc)-OH Boc-Hyp-OH Fmoc-Aib-OH N-Methyl-2-pyrrolidone 9-Fluorenylmethyl chloroformate CHLOROPHOSPHONAZO III Polyvinylpyrrolidone L-Proline L-PROLINE-(4-3H(N)) cis-4-Hydroxy-D-proline Fmoc-OSu Fmoc-L-glutamic acid

RARECHEM EM WB 0137

N-FMOC-TRANS-4-HYDROXY-L-PROLINE

N-FMOC-L-TRANS-4-HYDROXYPROLINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-TRANS-L-HYDROXYPROLINE

N-ALPHA-FMOC-L-TRANS-4-HYDROXYPROLINE

trans-N-Fmoc-L-4-hydroxyproline

trans-1-(((9H-Fluoren-9-yl)Methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

FMoc-Hyp

(9H-Fluoren-9-yl)MethOxy]Carbonyl Hyp-OH (Hyp of animal origin)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Hyp-OH (Hyp of Non-animal origin)

Fmoc-Hyp-OH >=98.0% (sum of enantiomers, HPLC)

Fmoc-L-trans-4-hydroxyproline≥ 99% (HPLC)

1,2-Pyrrolidinedicarboxylicacid, 4-hydroxy-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)-

N-Fmoc-trans-4-hydroxy-L-proline 98%

FMOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

FMOC-L-4-HYDROXYPROLINE

FMOC-HYP-OH

FMOC-HYP-OH (TRANS)

FMOC-HYDROXYPROLINE

FMOC-L-T-4-HYDROXYPROLINE

FMOC-L-TRANS-4-HYDROXYPROLINE

FMOC-L-HYDROXYPROLINE

FMOC-L-HYP-OH

FMOC-TRANS-4-HYDROXY-L-PROLINE

FMOC-TRANS-4-HYP-OH

(2S,4R)-N-ALPHA-(Y-FLUORENYLMETHOXYCARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

(2S,4R)-N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

N-Fmoc-cis-4-hydroxy-D-proline

FMOC-HYP-OH 99%MIN

(2R,4R)-N-FMOC-4-HYDROXY-D-PROLINE

NALPHA-9-Fluorenylmethoxycarbonyl-4-hydroxy-L-proline

(2S,4R)-1-(9H-Fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

trans-N-FMoc-4-hydroxy-L-proline, 97%

Fmoc-L-4-hydroxyproline ,98%

(2S,4R)-N-Fmoc-trans-4-hydroxy-L-proline

Fmoc-tarans-4-hydroxy-L-Proline

(2S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Fmoc-L-hydroxyproline USP/EP/BP

(4R)-1-Fmoc-4-hydroxy-L-proline

-(2S,4R)-(-)-4-hydroxypyrrolidine-2-carboxylic acid,

TIANFU-CHEM_-Fmoc-L-hydroxyproline

G1-15

trans-N-Fmoc-4-hydroxy-L-proline

Icatibant Impurity 12

88050-17-3

8850-17-3

C20HNO5

Proline Derivatives

Peptide Synthesis

Unnatural Amino Acid Derivatives

Specialty Synthesis

Hydroxyproline [Hyp]

Unusual Amino Acids

Fmoc-Amino acid series

Heterocyclic Compounds

Amino Acids