Cinchonidine

Product Name: Cinchonidine
CAS No.: 485-71-2
Chemical Name: Cinchonidine
Synonyms: (-)-Cinchonidine;Cinchondine;(8s,9r)-cinchonidine;(8a,9R)-Cinchonan-9-ol;L-Cin;A-QUINIDINE;Cinchovatine;CINCHONIDINE;2'-Hydroxy-4';Chinchonidine
CBNumber: CB5246395
Molecular Formula: C19H22N2O
Formula Weight: 294.39
MOL File: 485-71-2.mol

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Cinchonidine Property

Melting point:: 204-206 °C(lit.)
alpha: -115 º (c=1, EtOH)
Boiling point:: 436.16°C (rough estimate)
Density: 1.0863 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: -107.5 ° (C=1, EtOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: 0.25g/l
form: Crystalline Powder
pka: 5.80, 10.03(at 25℃)
color: White to cream
PH: 9 (0.2g/l, H2O, 20℃)
optical activity: [α]23/D 109.2°, c = 1.5 in ethanol
Water Solubility: Insoluble
Sensitive: Light Sensitive
Merck: 14,2286
BRN: 89690
Stability:: Stable, but light-sensitive. Incompatible with strong oxidizing agents.
InChIKey: KMPWYEUPVWOPIM-NAHPKXJFSA-N
LogP: 2.68 at 25℃
CAS DataBase Reference: 485-71-2(CAS DataBase Reference)
NIST Chemistry Reference: Cinchonidine(485-71-2)
EPA Substance Registry System: Cinchonan-9-ol, (8.alpha.,9R)- (485-71-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-42/43-36/37/38-20/22-48/22-43-22-63
Safety Statements: 22-24/25-36/37-36-26
RIDADR: 1544
WGK Germany: 3
RTECS: GD2975000
TSCA: Yes
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29392900
Toxicity: LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C80407
Product name: Cinchonidine
Purity: 96%
Packaging: 10g
Price: $38.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL80961
Product name: (-)-Cinchonidine
Purity: phyproof? Reference Substance
Packaging: 100mg
Price: $262
Updated: 2024/03/01

Sigma-Aldrich

Product number: C80407
Product name: Cinchonidine
Purity: 96%
Packaging: 100g
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: 44703
Product name: (−)-Cinchonidine
Purity: analyticalstandard
Packaging: 100mg
Price: $45.9
Updated: 2021/12/16

TCI Chemical

Product number: C0347
Product name: Cinchonidine
Purity: >98.0%(T)
Packaging: 25g
Price: $73
Updated: 2024/03/01

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Cinchonidine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

antiamebic, antiprotozoal

Uses

Cinchonidine occurs in most varieties of Cinchona bark and is stereoisomeric with Cinchonine. Cinchonidine exhibits Antimalarial properties.

Definition

ChEBI: 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise cinchonidine from aqueous EtOH. For the N-benzylcinchonidinium chloride see above entry in this section. [Beilstein 23 III/IV 2824.]

Cinchonidine Preparation Products And Raw materials

Raw materials

Preparation Products

Esfenvalerate 1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride, (S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE Fosinopril 1,1'-SPIROBIINDANE-7,7'-DIOL 1,1'-Bis(di-tert-butylphosphino)ferrocene N-Benzylcinchonidinium chloride (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Benazepril (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-PHENOXY QUININE SULFATE 2-(Dicyclohexylphosphino)biphenyl (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE (S)-1,1'-SPIROBIINDANE-7,7'-DIOL

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Cinchonidine Suppliers

Americas 1 Belgium 4 Canada 2 China 285 Europe 2 France 2 Germany 8 India 17 Japan 7 Poland 1 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 21 United States 53 Global 407

Carbosynth

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VWR International

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View Lastest Price from Cinchonidine manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Cinchonidine 485-71-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

Baoji Guokang Bio-Technology Co., Ltd.

Product: Cinchonidine 485-71-2
Price: US $371.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-04

Hebei Weibang Biotechnology Co., Ltd

Product: Cinchonidine 485-71-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

485-71-2, CinchonidineRelated Search:

4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Anisole 4-Methoxyphenylacetone Diethylstilbestrol Clothianidin 3-Methoxybenzaldehyde p-Anisidine Quinidine VINYL PROPIONATE 4-Methoxybenzylchloride Cinchonine Triethoxyvinylsilane Methanol DL-CARNITINE N-Vinyl-2-pyrrolidone Vinylmagnesium bromide p-Anisaldehyde (Trifluoromethoxy)benzene

(8-alpha,9r)-cinchonan-9-o

(8alpha,9theta)-cinchonan-9-o

(8s,9r)-cinchonidine

2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-

Cinchonan-9-ol

Cinchonan-9-ol, (8alpha,9R)-

Cinchovatine

Cinchonidinederivedcatalyst

{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol

Cinchonidine, 98.5-101% 100GR

Cinchonidine, 98.5-101% 25GR

Cinchondine

CINCHONIDINE

1-Cinchonidine

(-)-Cinchonidine (total base), may cont. up to 5% quinine

cinchonidine .base

Cinchonidine ,98.5%

Cinchonidine,()-Cinchonidine

(-)-CINCHONIDINE FOR RESOLUTION OF RACEM

(-)-Cinchonidine, 99%, may contain up to 5% quinine

(-)-Cinchonidine for resolution of racemates for synthesis

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](quinolin-4-yl)methanol

(3alpha,4beta,8alpha,9S)-cinchonan-9-ol

(3alpha,9R)-9-hydroxycinchonan-1-ium

(4beta,8alpha,9R)-cinchonan-1-ium-9-ol

(8alpha,9R)-9-hydroxycinchonan-1-ium

(9R)-cinchonan-1-ium-9-ol

(9R)-cinchonan-9-ol

Quinine Sulphate EP Impurity B

L-Cin

CINCHONAN-9-OL,(8,9R)-

A-QUINIDINE

ALPHA-QUINIDINE

(8alpha,9r)-cinchonan-9-ol

CINCHONIDINE: CINCHONAN-9-OL,(8,9R)-,

Cinchonidine,99%

[8α,9R]-Cinchonan-9-ol

Cinchonidine, 98.5-101%

CINCHONIDINE(RG)

L-CINCHONIDINE

Cinchonidine (base and/or unspecified salts)

4-Quinolyl-(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol

(R)-Quinolin-4-yl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol

(8S,9R)-Cinchonan-9-ol

(-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine

(8a,9R)-Cinchonan-9-ol

(R)-[(4S,5R,7S)-5-Ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-quinolin-4-ylmethanol

Cinchonidine, 98%, for synthesis

Cinchonidine &gt

Quinine EP Impurity B

(R)-Quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol

Cinchonidine USP/EP/BP

(-)-Cinchonidine

[(2R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol

2'-Hydroxy-4'

Cinchonidine (8CI)

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](quinolin-4-yl)methanol (cinchonidine)

Chinchonidine