ChemicalBook > CAS DataBase List > 5-bromo-3-chloropyridine-2-carbonitrile

5-bromo-3-chloropyridine-2-carbonitrile

Product Name
5-bromo-3-chloropyridine-2-carbonitrile
CAS No.
945557-04-0
Chemical Name
5-bromo-3-chloropyridine-2-carbonitrile
Synonyms
5-broMo-3-chloropicolinonitrile;5-Bromo-3-chL;5-broMo-3-chloro-2-cyanopyridine;5-broMo-2-cyano-3-chloropyridine;5-Bromo-3-chloro-2-pyridinitrile;5-bromo-3-chloro-2-Pyridinecarbonitrile;5-bromo-3-chloropyridine-2-carbonitrile;5-bromo-3-chloropicolinonitrile 98%;2-Pyridinecarbonitrile, 5-bromo-3-chloro-;5-bromo-3-chloropyridine-2-carbonitrile ISO 9001：2015 REACH
CBNumber
CB52500343
Molecular Formula
C6H2BrClN2
Formula Weight
217.45
MOL File
945557-04-0.mol
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5-bromo-3-chloropyridine-2-carbonitrile Property

Boiling point:
289.0±35.0 °C(Predicted)
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
-4.96±0.20(Predicted)
Appearance
White to yellow Solid
InChI
InChI=1S/C6H2BrClN2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H
InChIKey
SIYPZKHSXDFDRA-UHFFFAOYSA-N
SMILES
C1(C#N)=NC=C(Br)C=C1Cl
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B684413
Product name
5-Bromo-3-chloropyridine-2-carbonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
070183
Product name
5-Bromo-3-chloropyridine-2-carbonitrile
Purity
97%
Packaging
5g
Price
$144
Updated
2021/12/16
Matrix Scientific
Product number
070183
Product name
5-Bromo-3-chloropyridine-2-carbonitrile
Purity
97%
Packaging
1g
Price
$39
Updated
2021/12/16
Apolloscientific
Product number
OR17892
Product name
5-Bromo-3-chloropyridine-2-carbonitrile
Packaging
1g
Price
$48
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-D-X6
Product name
5-Bromo-3-chloropyridine-2-carbonitrile
Packaging
1g
Price
$53
Updated
2021/12/16
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5-bromo-3-chloropyridine-2-carbonitrile Chemical Properties,Usage,Production

Uses

5-Bromo-3-chloropyridine-2-carbonitrile is used as a reagent in organic synthesis. Its derivative 3-bromo-2-chloropyridine can be aminated with various substituted aminoethanols.

Synthesis

573675-27-1

945557-04-0

The general procedure for the synthesis of 5-bromo-3-chloro-2-pyridinecarbonitrile from 3-amino-5-bromo-2-pyridinecarbonitrile was as follows: to a suspension of 3-amino-5-bromo-2-cyano pyridine (198 mg, 1.00 mmol) in 37% hydrochloric acid (2.00 ml) and water (0.5 ml) at 0°C, sodium nitrite (83.0 mg, 1.20 mmol) and the reaction was stirred for 1 hour. Subsequently, copper powder (15 mg) was added and the mixture was refluxed for 30 minutes. After completion of the reaction, the mixture was cooled, the reaction was quenched with ice water and alkalized with 5N sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with brine and dried over anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography with 0-30% ethyl acetate/hexane as eluent to give 110 mg of 5-bromo-2-cyano-3-chloropyridine in 50% yield.

References

[1] Patent: WO2007/87488, 2007, A2. Location in patent: Page/Page column 24
[2] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 75

5-bromo-3-chloropyridine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-3-chloropyridine-2-carbonitrile Suppliers

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View Lastest Price from 5-bromo-3-chloropyridine-2-carbonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Henan Fengda Chemical Co., Ltd
Product
5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-06

945557-04-0, 5-bromo-3-chloropyridine-2-carbonitrileRelated Search:

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  • 5-bromo-3-chloro-2-Pyridinecarbonitrile
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  • 5-bromo-3-chloropyridine-2-carbonitrile ISO 9001：2015 REACH
  • 5-Bromo-3-chloro-2-pyridinitrile
  • 5-bromo-3-chloropicolinonitrile 98%
  • 945557-04-0