5-bromo-3-chloropyridine-2-carbonitrile

Product Name: 5-bromo-3-chloropyridine-2-carbonitrile
CAS No.: 945557-04-0
Chemical Name: 5-bromo-3-chloropyridine-2-carbonitrile
Synonyms: 5-broMo-3-chloropicolinonitrile;5-Bromo-3-chL;5-broMo-3-chloro-2-cyanopyridine;5-broMo-2-cyano-3-chloropyridine;5-Bromo-3-chloro-2-pyridinitrile;5-bromo-3-chloro-2-Pyridinecarbonitrile;5-bromo-3-chloropyridine-2-carbonitrile;5-bromo-3-chloropicolinonitrile 98%;2-Pyridinecarbonitrile, 5-bromo-3-chloro-;5-bromo-3-chloropyridine-2-carbonitrile ISO 9001：2015 REACH
CBNumber: CB52500343
Molecular Formula: C6H2BrClN2
Formula Weight: 217.45
MOL File: 945557-04-0.mol

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5-bromo-3-chloropyridine-2-carbonitrile Property

Boiling point:: 289.0±35.0 °C(Predicted)
Density: 1.85±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: -4.96±0.20(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C6H2BrClN2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H
InChIKey: SIYPZKHSXDFDRA-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(Br)C=C1Cl

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B684413
Product name: 5-Bromo-3-chloropyridine-2-carbonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 070183
Product name: 5-Bromo-3-chloropyridine-2-carbonitrile
Purity: 97%
Packaging: 5g
Price: $144
Updated: 2021/12/16

Matrix Scientific

Product number: 070183
Product name: 5-Bromo-3-chloropyridine-2-carbonitrile
Purity: 97%
Packaging: 1g
Price: $39
Updated: 2021/12/16

Apolloscientific

Product number: OR17892
Product name: 5-Bromo-3-chloropyridine-2-carbonitrile
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-D-X6
Product name: 5-Bromo-3-chloropyridine-2-carbonitrile
Packaging: 1g
Price: $53
Updated: 2021/12/16

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5-bromo-3-chloropyridine-2-carbonitrile Chemical Properties,Usage,Production

Uses

5-Bromo-3-chloropyridine-2-carbonitrile is used as a reagent in organic synthesis. Its derivative 3-bromo-2-chloropyridine can be aminated with various substituted aminoethanols.

Synthesis

573675-27-1

945557-04-0

The general procedure for the synthesis of 5-bromo-3-chloro-2-pyridinecarbonitrile from 3-amino-5-bromo-2-pyridinecarbonitrile was as follows: to a suspension of 3-amino-5-bromo-2-cyano pyridine (198 mg, 1.00 mmol) in 37% hydrochloric acid (2.00 ml) and water (0.5 ml) at 0°C, sodium nitrite (83.0 mg, 1.20 mmol) and the reaction was stirred for 1 hour. Subsequently, copper powder (15 mg) was added and the mixture was refluxed for 30 minutes. After completion of the reaction, the mixture was cooled, the reaction was quenched with ice water and alkalized with 5N sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with brine and dried over anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography with 0-30% ethyl acetate/hexane as eluent to give 110 mg of 5-bromo-2-cyano-3-chloropyridine in 50% yield.

References

[1] Patent: WO2007/87488, 2007, A2. Location in patent: Page/Page column 24
[2] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 75

5-bromo-3-chloropyridine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-3-chloropyridine-2-carbonitrile Suppliers

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View Lastest Price from 5-bromo-3-chloropyridine-2-carbonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Henan Fengda Chemical Co., Ltd

Product: 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 5-bromo-3-chloropyridine-2-carbonitrile 945557-04-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-06

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945557-04-0