methyl 5-bromo-1H-pyrrole-2-carboxylate
- Product Name
- methyl 5-bromo-1H-pyrrole-2-carboxylate
- CAS No.
- 934-07-6
- Chemical Name
- methyl 5-bromo-1H-pyrrole-2-carboxylate
- Synonyms
- 5-bromo-1H-Pyrrole-2-carboxylic acid methyl ester;1H-Pyrrole-2-carboxylic acid, 5-bromo-, methyl ester;methyl 5-bromo-1H-pyrrole-2-carboxylate, 10 mM in DMSO
- CBNumber
- CB52500363
- Molecular Formula
- C6H6BrNO2
- Formula Weight
- 204.02
- MOL File
- 934-07-6.mol
methyl 5-bromo-1H-pyrrole-2-carboxylate Property
- Melting point:
- 101-103 °C
- Boiling point:
- 290.5±20.0 °C(Predicted)
- Density
- 1.674±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- 14.18±0.50(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C6H6BrNO2/c1-10-6(9)4-2-3-5(7)8-4/h2-3,8H,1H3
- InChIKey
- ZYBOXSDTMZRWBC-UHFFFAOYSA-N
- SMILES
- N1C(Br)=CC=C1C(OC)=O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M292715
- Product name
- Methyl5-Bromo-1H-pyrrole-2-carboxylate
- Packaging
- 10g
- Price
- $2625
- Updated
- 2021/12/16
- Product number
- M292715
- Product name
- Methyl5-Bromo-1H-pyrrole-2-carboxylate
- Packaging
- 25g
- Price
- $4725
- Updated
- 2021/12/16
- Product number
- 092635
- Product name
- Methyl5-bromo-1H-pyrrole-2-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $2480
- Updated
- 2021/12/16
- Product number
- 4H58-9-2W
- Product name
- Methyl 5-bromo-1H-pyrrole-2-carboxylate
- Packaging
- 250mg
- Price
- $176
- Updated
- 2021/12/16
- Product number
- 4H58-9-2W
- Product name
- Methyl 5-bromo-1H-pyrrole-2-carboxylate
- Packaging
- 1g
- Price
- $392
- Updated
- 2021/12/16
methyl 5-bromo-1H-pyrrole-2-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.
Synthesis
1193-62-0
934-07-6
Synthesis of 5-bromo-1H-pyrrole-2-carboxylic acid methyl ester (53): 1H-pyrrole-2-carboxylic acid methyl ester (52; 10 g, 80 mmol) was dissolved in a solvent mixture of 800 mL tetrahydrofuran (THF) and 400 mL methanol (MeOH). The reaction mixture was cooled to 0 °C. N-bromosuccinimide (NBS; 15 g, 8.4 mmol) was added in 5 additions in batches over 1.5 hours. After addition, the reaction mixture was continued to be stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated and purified by silica gel column chromatography (eluent: 2% ethyl acetate/petroleum ether) to afford 4.3 g of 5-bromo-1H-pyrrole-2-carboxylic acid methyl ester 53 as a white solid in 26% yield.The LCMS analysis resulted in: m/z 206.0 [M + H] and a retention time t R = 1.50 min.
References
[1] Journal of the American Chemical Society, 2006, vol. 128, # 18, p. 6054 - 6055
[2] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6910 - 6919
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 16, p. 2574 - 2577
[4] Patent: WO2017/31213, 2017, A1. Location in patent: Paragraph 00361
[5] Patent: US2002/6943, 2002, A1
methyl 5-bromo-1H-pyrrole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 5-bromo-1H-pyrrole-2-carboxylate Suppliers
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View Lastest Price from methyl 5-bromo-1H-pyrrole-2-carboxylate manufacturers
- Product
- methyl 5-bromo-1H-pyrrole-2-carboxylate 934-07-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-09