ChemicalBook > CAS DataBase List > SU14813

SU14813

Product Name
SU14813
CAS No.
627908-92-3
Chemical Name
SU14813
Synonyms
SU14813;CS-1149;SU-14813; SU 14813;SU14813(Random Configuration);5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;(S)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N- [ 2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carb;5-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;1H-Pyrrole-3-carboxamide, 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-;c-Kit,Inhibitor,VEGFR,Vascular endothelial growth factor receptor,SU 14813,PDGFR,CD117,Platelet-derived growth factor receptor,SU-14813,SU14813,inhibit,SCFR
CBNumber
CB52516070
Molecular Formula
C23H27FN4O4
Formula Weight
442.48
MOL File
627908-92-3.mol
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SU14813 Property

Boiling point:
685.6±55.0 °C(Predicted)
Density 
1.341
storage temp. 
Store at -20°C
solubility 
DMSO : 44 mg/mL (99.44 mM; Need ultrasonic)
form 
Powder
pka
11.24±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

ChemScene
Product number
CS-0240
Product name
SU14813
Purity
98.90%
Packaging
5mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-0240
Product name
SU14813
Purity
98.90%
Packaging
10mg
Price
$114
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
2mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
5mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
A3844
Product name
SU14813
Packaging
10mg
Price
$307
Updated
2021/12/16
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SU14813 Chemical Properties,Usage,Production

Biological Activity

SU14813 (SU 014813) is a multi-receptor tyrosine kinase inhibitor with IC50 values of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit), respectively. It has potent antiangiogenic and antitumor activities.

in vitro

SU14813 inhibits ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets. It inhibits cellular ligand-dependent phosphorylation of VEGFR-2 (transfected NIH 3T3 cells) , PDGFR-β (transfected NIH 3T3 cells), KIT (Mo7e cells), and FLT3-internal tandem duplication (FLT3-ITD; MV4;11 cells) as well as FMS/CSF1R (transfected NIH 3T3 cells). SU14813 inhibits VEGFR- 2, PDGFR-β, and KIT phosphorylation in porcine aorta endothelial cells overexpressing these targets, with cellular IC 50 values of 5.2, 9.9, and 11.2 nM, respectively. Also it inhibits the growth of U-118MG with an IC 50 of 50 to 100 nM.

in vivo

SU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduces growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> KIT
(Cell-free assay)
TargetValue
VEGFR1
(Cell-free assay)		 2 nM
PDGFRβ
(Cell-free assay)		 4 nM
15 nM
VEGFR2
(Cell-free assay)		 50 nM

SU14813 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU14813 Suppliers

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View Lastest Price from SU14813 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
SU14813 627908-92-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Career Henan Chemical Co
Product
SU14813 627908-92-3
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

627908-92-3, SU14813Related Search:

WAY-607500 su5204 SU 5214 CIVENTICHEM CV-409 SU5402 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312 Glecaprevir ABT-530 NBQX DISODIUM SALT LOXO-292 Futibatinib

  • SU14813
  • 5-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • CS-1149
  • SU14813(Random Configuration)
  • SU-14813; SU 14813
  • 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N- [ 2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carb
  • 1H-Pyrrole-3-carboxamide, 5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-
  • 5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • c-Kit,Inhibitor,VEGFR,Vascular endothelial growth factor receptor,SU 14813,PDGFR,CD117,Platelet-derived growth factor receptor,SU-14813,SU14813,inhibit,SCFR
  • (S)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • 627908-92-3