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BrettPhosPalladacycle

Reaction
Product Name
BrettPhosPalladacycle
CAS No.
1148148-01-9
Chemical Name
BrettPhosPalladacycle
Synonyms
BrettPhos Pd G1;BrettPhos precatalyst;BrettPhos Palladacycle;BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct;BrettPhos Pd G1 MTBE adduct;BrettPhos Palladacycle Gen. 1;chloro-(2-phenylethylamino)palladium;[2-(2-aminoethyl)phenyl]palladium(1+);(BrettPhos) palladium(II) phenethylamine chloride;Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-...
CBNumber
CB52614378
Molecular Formula
C43H63ClNO2PPd
Formula Weight
798.83
MOL File
1148148-01-9.mol
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BrettPhosPalladacycle Property

Melting point:
198-204 °C
form 
Powder
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
718750
Product name
BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity
may contain up to 1 mole equivalent of MTBE, 97%
Packaging
1g
Price
$533
Updated
2024/03/01
Sigma-Aldrich
Product number
718750
Product name
BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity
may contain up to 1 mole equivalent of MTBE, 97%
Packaging
5g
Price
$1450
Updated
2024/03/01
Strem Chemicals
Product number
46-0267
Product name
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1]
Packaging
100mg
Price
$62
Updated
2024/03/01
Strem Chemicals
Product number
46-0267
Product name
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II), min. 98% [BrettPhos Palladacycle Gen. 1]
Packaging
500mg
Price
$180
Updated
2024/03/01
Sigma-Aldrich
Product number
718750
Product name
BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity
may contain up to 1 mole equivalent of MTBE, 97%
Packaging
100mg
Price
$34.96
Updated
2024/03/01
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BrettPhosPalladacycle Chemical Properties,Usage,Production

Reaction

  1. Catalyst for cross-coupling reactions using aryl mesylates with electron-deficient anilines.
  2. Catalyst for rapid C-N bond-forming processes at low catalyst loading.
  3. Cross-coupling of 3-Bromo-2-aminopyridine with primary amines.

Uses

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:

  • C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
  • Amination reaction
  • N-arylation of aminophenols

General Description

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.

BrettPhosPalladacycle Preparation Products And Raw materials

Raw materials

Preparation Products

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BrettPhosPalladacycle Suppliers

China 83 India 1 United States 7 Global 91
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
17453
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Strem Chemicals, Inc.
Tel
--
Fax
--
Email
info@strem.com
Country
United States
ProdList
4910
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
NE Scientific
Tel
--
Fax
--
Country
United States
ProdList
5030
Advantage
55
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View Lastest Price from BrettPhosPalladacycle manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II) 1148148-01-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-04-21
Wuhan LPBchem Technology Co.,Ltd
Product
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) /BrettPhos Pd G1 1148148-01-9
Price
US $10.00-10.00/g
Min. Order
1g
Purity
0.98
Supply Ability
50kg
Release date
2020-09-27
Career Henan Chemical Co
Product
Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) 1148148-01-9
Price
US $1.00/g
Min. Order
1g
Purity
Min98%
Supply Ability
g/kg/ton
Release date
2020-01-10

1148148-01-9, BrettPhosPalladacycleRelated Search:

Chloro(2-dicyclohexylphosphino-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II), Min. 98% [BrettPhos Palladacycle] XPhos Pd G3 SPhos Palladacycle Gen. 4 XPhos Pd G4 Xantphos Pd G3 BrettPhos Pd G3 XPhos Pd G2 RuPhos Pd G1 Methyl t--Butyl Ether Adduct SPhos Pd G2 Palladacycle Gen. 3 t-BuXphos Palladacycle Gen. 4 RuPhos Palladacycle Gen. 4 t-BuBrettPhos Palladacycle Gen. 3 SPhos Pd G3 SPhos Pd G1, Methyl t-Butyl Ether Adduct RuPhos Pd G2 tBuXPhos Pd G1 XPhos Pd G1

  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II),98%
  • BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II), Min. 98% [BrettPhos Palladacycle]
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoeth
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-Minoethyl)phenyl]palladiuM(II),Min.98%[BrettPhosPalladacycle]
  • (BrettPhos) palladium(II) phenethylamine chloride
  • BrettPhos Palladacycle
  • BrettPhos precatalyst
  • Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ii)
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-amino
  • CHLORO[2-(DICYCLOHEXYLPHOSPHINO)-3,6-DIMETHOXY-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL][2-(2-AMINOETHYL)PHENYL]PALLADIUM(II),MIN.98%[BRETTPHOSPALLADACYCLEGEN.1]
  • (SP-4-4)-[2-[2-(Amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-κP]palladium
  • Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II) [BrettPhos Palladacycle]
  • [2-(2-aminoethyl)phenyl]palladium(1+)
  • dicyclohexyl-[3,6-dimethoxy-2-(2,4,6-triisopropylphenyl)phenyl]phosphane
  • BrettPhos Palladacycle Gen. 1
  • Chloride (2-dicyclohexylphosphino-3,6-dimethoxy-2 ', 4', 6 '- triisopropyl-1,1' - biphenyl) [2 - (2-aminoethyl phenyl)] palladium (II)
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / BrettPhos Pd G1
  • Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-κP]-, (SP-4-4)-
  • BrettPhos Pd G1
  • Chloro[2-(dicyclohexylphosphino)-2',4',6'-triisopropyl-3,6-dimethoxybiphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-...
  • BrettPhos Pd G1 / Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride
  • chloro-(2-phenylethylamino)palladium
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • BrettPhos Pd G1 MTBE adduct
  • Chloro[2-(dicyclohexylphosphino)-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl][2-(2-aminoethyl)phenyl]palladium(II)
  • Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-κP]-, (SP-4-4)-
  • 1148148-01-9
  • C43H63ClNO2PPd
  • C48H74ClNO3PPd
  • Buchwald Ligands&Precatalysts
  • Buchwald Precatalysts Series
  • Pd