ChemicalBook > CAS DataBase List > 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Product Name
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
CAS No.
1267610-26-3
Chemical Name
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
Synonyms
1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one;Apixaban intA;Apixaban Impurity S;Apixaban Impurity 47;Apixaban Impurity 50;Apixaba inretMediate A;Apixaban related impurities 2;4-Pyrimidinol,2-methoxy-12-methyl-;1-(4-aminophenyl)-5,6-dihydro-3-(4-;1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py
CBNumber
CB52660744
Molecular Formula
C15H19N3O2
Formula Weight
273.33
MOL File
1267610-26-3.mol
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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Property

Melting point:
>246°C (dec.)
Boiling point:
491.5±45.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.96±0.10(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey
YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A637898
Product name
1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone
Packaging
1g
Price
$425
Updated
2021/12/16
TRC
Product number
A637898
Product name
1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone
Packaging
50g
Price
$605
Updated
2021/12/16
AK Scientific
Product number
Z3503
Product name
1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone
Packaging
25mg
Price
$85
Updated
2021/12/16
Crysdot
Product number
CD11303316
Product name
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity
95+%
Packaging
5g
Price
$100
Updated
2021/12/16
Ambeed
Product number
A431106
Product name
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
Purity
95%
Packaging
25g
Price
$105
Updated
2021/12/16
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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Chemical Properties,Usage,Production

Uses

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Synthesis

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production In the process.

Synthesis


Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 ??C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 ??C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Suppliers

China 246 India 18 United States 10 Global 274
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View Lastest Price from 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Speranza Chemical Co., Ltd.
Product
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3
Price
US $25.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Apixaban Impurity 50 1267610-26-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-05

1267610-26-3, 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinoneRelated Search:

Apixaban Impurity 16 Apixaban IMpurity 2 Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban Impurity 11 Apixaban IMpurity(BMS-591329-01) Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone Apixaban Apixaban Impurity BMS-591329

  • 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
  • 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one
  • 2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-
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