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UNC0646

Product Name
UNC0646
CAS No.
1320288-17-2
Chemical Name
UNC0646
Synonyms
CS-792;UNC0646;UNC0646/UNC-0646;UNC 0646;UNC0646;UNC-0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
CBNumber
CB52667561
Molecular Formula
C36H59N7O2
Formula Weight
621.9
MOL File
1320288-17-2.mol
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UNC0646 Property

Boiling point:
754.6±70.0 °C(Predicted)
Density 
1.128±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble2mg/mL, clear (warmed)
pka
9.34±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0633
Product name
UNC0646
Purity
≥98% (HPLC)
Packaging
5mg
Price
$156
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0633
Product name
UNC0646
Purity
≥98% (HPLC)
Packaging
25mg
Price
$496
Updated
2024/03/01
Cayman Chemical
Product number
11085
Product name
UNC0646
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
11085
Product name
UNC0646
Purity
≥95%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
11085
Product name
UNC0646
Purity
≥95%
Packaging
10mg
Price
$210
Updated
2024/03/01
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UNC0646 Chemical Properties,Usage,Production

Description

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.

Uses

UNC0646 is a novel Protein lysine methyltransferase G9a inhibitor.

Definition

ChEBI: N-(1-cyclohexyl-4-piperidinyl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-2-(4-propan-2-yl-1,4-diazepan-1-yl)-4-quinazolinamine is a member of quinazolines.

storage

+4°C

References

[1] liu f, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j. optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011;54(17):6139-50.
[2] liu f, barsyte-lovejoy d, li f, xiong y, korboukh v, huang xp, allali-hassani a, janzen wp, roth bl, frye sv, arrowsmith ch, brown pj, vedadi m, jin j. discovery of an in vivo chemical probe of the lysine methyltransferases g9a and glp. j med chem. 2013;56(21):8931-42.

UNC0646 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC0646 Suppliers

China 49 France 1 India 1 United Kingdom 1 United States 14 Global 66
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1320288-17-2, UNC0646Related Search:

UNC0321 (trifluoroacetate salt) UNC2541 UNC 1079 UNC 0224 1-Methyl-4-piperidone N-Methylpiperidine 3-Hydroxy-1-methylpiperidine UNC3866 UNC0379 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 NUC-7738 UNC2025 UNC0638 UNC-0642

  • UNC0646
  • N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine
  • UNC0646/UNC-0646
  • N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
  • N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
  • (1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE
  • UNC 0646;UNC0646;UNC-0646
  • CS-792
  • 4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
  • H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53
  • N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine
  • 1320288-17-2
  • C36H59N7O2