ChemicalBook > CAS DataBase List > 4-Methyl-2-(1-piperidinyl)-quinoline

4-Methyl-2-(1-piperidinyl)-quinoline

Product Name
4-Methyl-2-(1-piperidinyl)-quinoline
CAS No.
5465-86-1
Chemical Name
4-Methyl-2-(1-piperidinyl)-quinoline
Synonyms
ML 204;NSC 25850;ML-204;ML204;ML 204, TRPC4 blocker;4-Methyl-2-(1-piperidinyl)-quinoline;4-methyl-2-(piperidin-1-yl)quinoline;Quinoline, 4-methyl-2-(1-piperidinyl)-;Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
CBNumber
CB52695379
Molecular Formula
C15H18N2
Formula Weight
226.32
MOL File
5465-86-1.mol
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4-Methyl-2-(1-piperidinyl)-quinoline Property

Melting point:
72-73 °C
Boiling point:
177-180 °C(Press: 4.5 Torr)
Density 
1.102±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL at warmed (clear solution)
form 
powder
pka
7.34±0.61(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0400
Product name
ML204
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0400
Product name
ML204
Purity
≥98% (HPLC)
Packaging
25mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
5mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
10mg
Price
$163
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
25mg
Price
$360
Updated
2024/03/01
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4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties,Usage,Production

Description

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

Uses

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

storage

Store at +4°C

4-Methyl-2-(1-piperidinyl)-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methyl-2-(1-piperidinyl)-quinoline Suppliers

Canada 1 China 66 India 2 United Kingdom 2 United States 17 Global 88
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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EnliPharma Technology Co., Ltd
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0551-66399836 18955197623
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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021-34692979
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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Cool Pharm, Ltd
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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YouCoChem (Beijing) Chemical Technology Co., Ltd.
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18800159827
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youcochem@163.com
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Shanghaizehan biopharma technology co., Ltd.
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5465-86-1, 4-Methyl-2-(1-piperidinyl)-quinolineRelated Search:

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  • 4-Methyl-2-(1-piperidinyl)-quinoline
  • ML 204
  • NSC 25850
  • ML-204;ML204
  • 4-methyl-2-(piperidin-1-yl)quinoline
  • Quinoline, 4-methyl-2-(1-piperidinyl)-
  • Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
  • ML 204, TRPC4 blocker
  • 5465-86-1
  • 5485-86-1
  • Inhibitors
  • Aromatics, Heterocycles, Inhibitors