ChemicalBook > CAS DataBase List > 4-Methyl-2-(1-piperidinyl)-quinoline

4-Methyl-2-(1-piperidinyl)-quinoline

Product Name
4-Methyl-2-(1-piperidinyl)-quinoline
CAS No.
5465-86-1
Chemical Name
4-Methyl-2-(1-piperidinyl)-quinoline
Synonyms
ML 204;NSC 25850;ML-204;ML204;ML 204, TRPC4 blocker;4-Methyl-2-(1-piperidinyl)-quinoline;4-methyl-2-(piperidin-1-yl)quinoline;Quinoline, 4-methyl-2-(1-piperidinyl)-;Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
CBNumber
CB52695379
Molecular Formula
C15H18N2
Formula Weight
226.32
MOL File
5465-86-1.mol
More
Less

4-Methyl-2-(1-piperidinyl)-quinoline Property

Melting point:
72-73 °C
Boiling point:
177-180 °C(Press: 4.5 Torr)
Density 
1.102±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL at warmed (clear solution)
form 
powder
pka
7.34±0.61(Predicted)
color 
white to beige
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0400
Product name
ML204
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0400
Product name
ML204
Purity
≥98% (HPLC)
Packaging
25mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
5mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
10mg
Price
$163
Updated
2024/03/01
Cayman Chemical
Product number
15626
Product name
ML-204
Purity
≥98%
Packaging
25mg
Price
$360
Updated
2024/03/01
More
Less

4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties,Usage,Production

Description

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

Uses

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

storage

Store at +4°C

4-Methyl-2-(1-piperidinyl)-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Methyl-2-(1-piperidinyl)-quinoline Suppliers

Canada 1 China 66 India 2 United Kingdom 2 United States 17 Global 88
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

5465-86-1, 4-Methyl-2-(1-piperidinyl)-quinolineRelated Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

  • 4-Methyl-2-(1-piperidinyl)-quinoline
  • ML 204
  • NSC 25850
  • ML-204;ML204
  • 4-methyl-2-(piperidin-1-yl)quinoline
  • Quinoline, 4-methyl-2-(1-piperidinyl)-
  • Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
  • ML 204, TRPC4 blocker
  • 5465-86-1
  • 5485-86-1
  • Inhibitors
  • Aromatics, Heterocycles, Inhibitors