ChemicalBook > CAS DataBase List > Glycine ethyl ester hydrochloride

Glycine ethyl ester hydrochloride

Product Name
Glycine ethyl ester hydrochloride
CAS No.
623-33-6
Chemical Name
Glycine ethyl ester hydrochloride
Synonyms
ETHYL GLYCINATE HYDROCHLORIDE;GLYCINE ETHYL ESTER;GLYCINE ETHYL ESTER HCL;GEE;H-GLY-OET HCL;ETHYL AMINOACETATE HYDROCHLORIDE;usafdo-10;ycine EthyL;Gly-OEt HCl;GLYCINE-OET HCL
CBNumber
CB5275670
Molecular Formula
C4H9NO2.ClH
Formula Weight
139.58
MOL File
623-33-6.mol
More
Less

Glycine ethyl ester hydrochloride Property

Melting point:
145-146 °C(lit.)
Density 
1.371 g/cm3
storage temp. 
2-8°C
solubility 
>1000 g/L (20 °C)
form 
Crystalline Powder
pka
pK1:7.66(＋1) (25°C)
color 
White
Odor
Odorless
PH
2.9 (10g/l, H2O, 20℃)
Water Solubility 
>1000 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3594034
InChIKey
TXTWXQXDMWILOF-UHFFFAOYSA-N
CAS DataBase Reference
623-33-6(CAS DataBase Reference)
EPA Substance Registry System
Glycine, ethyl ester, hydrochloride (623-33-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
41-36/37/38
Safety Statements 
26-39-24/25-37/39
WGK Germany 
3
RTECS 
MC0525000
TSCA 
Yes
HS Code 
29224995
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
5G
Price
$35.4
Updated
2024/03/01
Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
100g
Price
$65.6
Updated
2024/03/01
Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
500g
Price
$97.7
Updated
2024/03/01
TCI Chemical
Product number
G0102
Product name
Glycine Ethyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
G0102
Product name
Glycine Ethyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
500g
Price
$75
Updated
2024/03/01
More
Less

Glycine ethyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Uses

As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.

Purification Methods

Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]

Glycine ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Hydrogen chloride ethanol solution Ethanol Hydrochloric acid alcohol Glycine weak Hydrochloric acid Hydrogen Hexamethylenetetramine

Preparation Products

1-(Boc-amino)cyclopropanecarboxylic acid N-Boc-3-cyano-4-hydroxypyrrolidine ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate ETHYL 2-[(2-THIENYLCARBONYL)AMINO]ACETATE 2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate Ethyl N-(diphenylmethylene)glycinate Ethyl imidazole-4-carboxylate ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER H-GLY-AMC HBR 1-Aminocyclopropanecarboxylic acid Glycine methyl ester hydrochloride N-FORMYLGLYCINE ETHYL ESTER 3-BROMO-6-METHYL-2-OXO-1(2H)-PYRAZINEACETIC ACID ETHYL ESTER Anagrelide ethyl 2-(3,4-dihydro-6-methyl-2,3-dioxopyrazin-1(2H)-yl)acetate Ethyl diazoacetate 4-Imidazolemethanol hydrochloride Tetramethrin 4-BOC-AMINOMETHYL-1-N-BOC-PYRROLIDIN-3-OL 4,5,6,7-TETRAHYDRO-2-METHYLFURO[2,3-C]PYRIDINE
More
Less

Glycine ethyl ester hydrochloride Suppliers

Americas 1 Austria 1 Belgium 3 Canada 1 China 591 Europe 5 France 1 Germany 13 Hungary 1 India 66 Japan 8 Poland 1 Slovakia 1 South Korea 1 Switzerland 6 United Kingdom 15 United States 60 Global 775
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
AB PharmaTech,LLC
Tel
323-480-4688
Fax
323-480-4688
Email
sales@acrospharmatech.com
Country
United States
ProdList
989
Advantage
55
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Advanced ChemTech (a division of CreoSalus Inc.)
Tel
--
Fax
--
Email
info@advancedchemtech.com
Country
United States
ProdList
177
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
Moravek, Inc.
Tel
--
Fax
--
Email
info@moravek.com
Country
United States
ProdList
279
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
AAPPTEC
Tel
--
Fax
--
Email
info@aapptec.com
Country
United States
ProdList
533
Advantage
0
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Daniel Lab Canada
Tel
--
Fax
--
Country
United States
ProdList
273
Advantage
50
Peptides International, Inc.
Tel
--
Fax
--
Email
peptides@pepnet.com
Country
United States
ProdList
555
Advantage
72
Labseeker Inc
Tel
--
Fax
--
Email
marketing@labseeker.com
Country
United States
ProdList
1495
Advantage
55
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Anthem Pharmaceutical Research LLC
Tel
--
Fax
--
Email
sales@anthempharma.com
Country
United States
ProdList
3040
Advantage
30
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Jupiter Bioscience Limited
Tel
--
Fax
--
Email
vksaipriya@jupiterbioscience.com
Country
United States
ProdList
247
Advantage
68
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Empire Chemicals
Tel
--
Fax
--
Email
global@empirechemicals.com
Country
United States
ProdList
190
Advantage
38
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from Glycine ethyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-Gly-Oet.HCl 623-33-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-27
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Glycine ethyl ester hydrochloride 623-33-6
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-12-24
Hebei Weibang Biotechnology Co., Ltd
Product
Glycine ethyl ester hydrochloride 623-33-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29

623-33-6, Glycine ethyl ester hydrochlorideRelated Search:

Trinexapac-ethyl Topotecan hydrochloride Glycine methyl ester hydrochloride Ethyl L-phenylalaninate hydrochloride Glycine Ethylparaben Ethanol Ethyl acetate Ethyl nipecotate 4-Aminophenylacetic acid Creatine ethyl ester hydrochloride L-Cysteine ethyl ester hydrochloride ISOXADIFEN-ETHYL 7-Amino-heptanoic acid ethyl ester hydrochloride Ethyl cyanoacetate 4-Hydroxy-D-(-)-2-phenylglycine L-Arginine ethyl ester dihydrochloride Ethyl acrylate

  • Glycineethylesterhydrochlor
  • Glycocollethylesterhydrochloride
  • usafdo-10
  • glycine ethyhydnchlordeester
  • Glycineethylester·HCl,Glycineethylesterhydrochloride
  • Ethyl 2-aminoacetate, hydrochloride
  • Glycine ethyl ester hydrochloride ,98%
  • 2-Aminoacetic acid ethyl·hydrochloride
  • Aminoacetic acid ethyl·hydrochloric acid
  • Glycine ethyl·hydrochloride
  • (2-Ethoxy-2-oxoethyl)aMMoniuM Chloride
  • Glycine Ethyl Ester Monohydrochloride
  • Glycine Hydrochloride Ethyl Ester
  • ETHYL GLYCINATE HYDROCHLORIDE FOR SYNTHE
  • Glycine ethyl ester HC1
  • Glycine ethyl ester hydrochloride, 99% 100GR
  • Glycine ethyl ester hydrochloride, 99% 500GR
  • Glycine ethylester HCI
  • ycine EthyL
  • RARECHEM AL BW 0032
  • H-GLY-OET HCL
  • GLYCINE ETHYL ESTER
  • GLYCINE ETHYL ESTER HCL
  • GLYCINE ETHYL ESTER HYDROCHLORIDE
  • GLYCINE-OET HCL
  • ETHYL AMINOACETATE HCL
  • ETHYL AMINOACETATE HYDROCHLORIDE
  • ETHYL GLYCINATE HYDROCHLORIDE
  • AMINO-ACETIC ACID ETHYL ESTER
  • AMINOACETIC ACID ETHYL ESTER HYDROCHLORIDE
  • Ethyl glycinate hydrochloride~H-Gly-OEt.HCl
  • Ethyl Glycinate, HCl (1.00893)
  • Glycine ethyl ester hydrochloride 99%
  • Gly-OEt HCl
  • Glycineethylesterhydrochloride,99%
  • GEE
  • GlyClne ethyl ester HCl
  • Ethyl glycinate hydrochloride for synthesis
  • Glycine ethyl ether hydrochloride
  • GLYCINE ETHYL ESTER .HCl (623-33-6)
  • GlycineEthylEsterHydrochloride&gt
  • Ethylglycinathydrochlorid
  • Glycine Impurity 10
  • glycine ethyl ester hydrochloric acid
  • Ethyl glycine hydrochloride
  • Glycine ethyl ester hydrochloride USP/EP/BP
  • Glycine ethyl ester hydrochloride25
  • GLYCINE ETHYL ESTER HYDROCHLORIDE For Synthesis
  • Glycine hexanoate hydrochloride
  • Ethyl glycerate hydrochloride
  • Glycine Ethyl Ester Hydrochloride (Ethyl Glycinate Hydrochloride)
  • Glycine ethylester hydrochloride - Assay 99%
  • Glycine Ethylester Hydrochloride 99% For Synthesis
  • 623-33-6
  • C4H9NO2HClC4H10ClNO2
  • C4H9NO2xHCl
  • CH3CH2O2CCH2NH2HCl
  • NH2CH2COOC2H5HCl