ChemicalBook > CAS DataBase List > (R)-Boc-Nipecotic acid

(R)-Boc-Nipecotic acid

Product Name: (R)-Boc-Nipecotic acid
CAS No.: 163438-09-3
Chemical Name: (R)-Boc-Nipecotic acid
Synonyms: (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID;N-BOC-(R)-NIPECOTIC ACID;(R)-BOC-NIP;BOC-R-NIP-OH;BOC-D-NIP-OH;(r)-boc-nip-oh;Boc (R)-nipecot;(R)-Boc-NipecoticAci;Boc-D-nipecotic acid;Boc-(R)-β2-Homopro-OH
CBNumber: CB5287990
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 163438-09-3.mol

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(R)-Boc-Nipecotic acid Property

Boiling point:: 353.2±35.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.49±0.20(Predicted)
form: Crystalline Powder
color: White
BRN: 5539297
InChI: InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1
InChIKey: NXILIHONWRXHFA-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H](C(O)=O)C1
CAS DataBase Reference: 163438-09-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4836
Product name: (R)-Boc-Nip-OH
Purity: min. 98.0 %
Packaging: 1G
Price: $137
Updated: 2025/07/31

TRC

Product number: B663873
Product name: (R)-N-Boc-piperidine-3-carboxylicAcid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J93495
Product name: (R)-N-Boc-piperidine-3-carboxylicacid
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: J93495
Product name: (R)-N-Boc-piperidine-3-carboxylicacid
Packaging: 5g
Price: $15
Updated: 2021/12/16

Chem-Impex

Product number: 16996
Product name: Boc-D-nipecoticacid,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $16.8
Updated: 2021/12/16

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(R)-Boc-Nipecotic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-Boc-D-nipecotic acid is used as an organic chemical synthesis intermediate.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

498-95-3

163438-09-3

Step 1: 3-Piperidinecarboxylic acid (1.05 g, 8.1 mmol) was dissolved in a solvent mixture of tetrahydrofuran (20 mL) and water (20 mL). Di-tert-butyl dicarbonate (2.48 g, 11.4 mmol) and sodium bicarbonate (0.96 g, 11.4 mmol) were added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the mixture was diluted with water and ether. The aqueous layer was adjusted to pH=2 with concentrated hydrochloric acid and then extracted with dichloromethane. The organic layers were combined, dried over sodium sulfate, and concentrated to give (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1.8 g, 97% yield). retention time by LCMS (Condition A) = 3.26 min, and m/z = 230 ([M+H]+) was observed by mass spectrum.

References

[1] Patent: WO2005/14540, 2005, A1. Location in patent: Page/Page column 39
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6456 - 6468
[3] Patent: WO2010/120889, 2010, A1. Location in patent: Page/Page column 55; 60

(R)-Boc-Nipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-Boc-Nipecotic acid Suppliers

China 190 Europe 3 France 1 Germany 5 India 13 Japan 4 Switzerland 3 United Kingdom 11 United States 50 Global 280

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View Lastest Price from (R)-Boc-Nipecotic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-Boc-Nipecotic acid 163438-09-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-Boc-Nipecotic acid 163438-09-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (R)-Boc-Nipecotic acid 163438-09-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-12

163438-09-3, (R)-Boc-Nipecotic acidRelated Search:

Fmoc-Lys(Boc)-OH Boc-Aib-OH N-Boc-L-valine Folic acid Stearic acid Ethyl 2-(Chlorosulfonyl)acetate Haloperidol Thalidomide Nipecotic acid (R)-1-Boc-3-Aminopiperidine Citric acid BOC-GLY-LEU-OH Ascoric Acid Carbonyl iron powder Diphenoxylate Piperidine L-1-Boc-Nipecotic acid (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER

(R)-1-BOC-NIPECOTIC ACID

(R)-1-BOC-PIPERIDINE-3-CARBOXYLIC ACID

(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID

(R)-BOC-NIP

(R)-BOC-NIPECOTIC ACID

(r)-boc-nip-oh

(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(R)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID

(R)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

(R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid

BOC-R-NIP-OH

BOC-D-NIP-OH

D-1-BOC-NIPECOTIC ACID

N-Boc-(R)-3-carboxylic acid piperidine

N-BOC-R- Piperidine-3-carboxylic acid

N-t-BOC-(R)-Nipecotic acid

(R)-Boc-Nip-OH >=97.0% (HPLC)

1-Boc-D-nipecoticacid,97%

Boc-(R)-beta2-Homopro-OH

R-1-BOC-3-Nipecotic acid

(R)-3-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

(R)-N-Boc-piperidine-3-carboxylic Acid,99%e.e.

(R)-1-(TERT-BUTOXYCARB

1-(tert-butoxy-oxomethyl)-3-piperidinecarboxylic acid

Boc-(R)-β2-Homopro-OH

N-Boc-(R)-Nipecotic acid 95+%

(R)-(-)-N-BOC-NIPECOTIC ACID

N-BOC-(R)-NIPECOTIC ACID

N-tert-Butoxycarbonyl-(R)-nipecotic acid

(3R)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylic acid

(R)-Boc-Piperidine-3-Carboxylic Acid

(R)-BOC-NIPECOTIC ACID: (R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

(R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID ,98%

(R)-N-t-Butyloxycarbonyl-nipecotic acid, (R)-N-t-butyloxycarbonyl-piperidine-3-carboxylic acid

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3R)-

Boc-(R)-nipecotic acid

(3R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic acid

(3R)-1-[[(1,1-Dimethylethyl)oxy]carbonyl]-3-piperidinecarboxylic acid

(3R)-Piperidine-1,3-dicarboxylic acid 1-tert-butyl ester

(R)-N-(tert-Butoxycarbonyl)nipecotic acid

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3R)- (9CI)

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (R)-

Boc (R)-nipecot

(R)-N-Boc-piperidine-3-carboxylic acid, (R)-Boc-nipecotic acid, Boc-(R)-β2-Homopro-OH

1-Boc-D-nipecoticacid

(R)-Boc-NipecoticAci

(R)-1-Boc-3-piperidinecarboxylic Acid

(R)-Boc-Nipecotic acid USP/EP/BP

N-(t-Butoxycarbonyl)-D-nipecotic acid

(3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid

(R)-N-t-Butyloxycarbonyl-nipecotic acid //

Boc-nipecotic acid methyl ester, 98%+

Boc-nipecotic acid methyl ester

(3R)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate

1-(1,1-Dimethylethyl) (3R)-1,3-piperidinedicarboxylate

Boc-D-nipecotic acid