ChemicalBook > CAS DataBase List > 4-Amino-5-imidazolecarboxamide hydrochloride

4-Amino-5-imidazolecarboxamide hydrochloride

Product Name
4-Amino-5-imidazolecarboxamide hydrochloride
CAS No.
72-40-2
Chemical Name
4-Amino-5-imidazolecarboxamide hydrochloride
Synonyms
AICA;AICA HCL;AIC .cntdot. HCl;AICA HYDROCHLORIDE;TIMTEC-BB SBB003938;5-Amino-1H-imidazoL;LABOTEST-BB LT00440910;e-4-carboxamide hydrochL;Temozolomide intermediate;Dacarbazine EP Impurity B
CBNumber
CB5300628
Molecular Formula
C4H7ClN4O
Formula Weight
162.58
MOL File
72-40-2.mol
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4-Amino-5-imidazolecarboxamide hydrochloride Property

Melting point:
250-252 °C (dec.)(lit.)
storage temp. 
2-8°C
solubility 
water: soluble50mg/mL, clear, light yellow
form 
Crystals or Crystalline Powder
color 
White
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
BRN 
3701645
Stability:
Hygroscopic
InChI
InChI=1S/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H
InChIKey
MXCUYSMIELHIQL-UHFFFAOYSA-N
SMILES
C1(N=CNC=1N)C(=O)N.Cl
CAS DataBase Reference
72-40-2(CAS DataBase Reference)
NIST Chemistry Reference
Imidazole-4(5)-carboxamide, 5-(4)-amino-, hydrochloride(72-40-2)
EPA Substance Registry System
1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride (72-40-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
NI3911000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29332990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
164968
Product name
5-Amino-4-imidazolecarboxamide hydrochloride
Purity
98%
Packaging
5g
Price
$23.6
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2304
Product name
Dacarbazine Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1162320
Product name
Dacarbazine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
A1175
Product name
5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$55
Updated
2024/03/01
TCI Chemical
Product number
A1175
Product name
5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$203
Updated
2024/03/01
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4-Amino-5-imidazolecarboxamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

very slightly beige fine powder

Uses

5-Amino-4-imidazolecarboxamide hydrochloride was used in the synthesis of heterocyclic compounds such as guanine, purines and pyrimidines.

General Description

Corrosion inhibition and adsorption characteristics of 5-amino-4-imidazolecarboxamide hydrochloride on aluminum in 1M HCl has been investigated.

Synthesis

47 g of sodium nitrite was dissolved in 1.2 liters of water; The solution was cooled to 0° C. 100 g of 5-aminoimidazole-4 carboxamide was dissolved in a solution of hydrochloric acid (80 ml of 36% HCL in 720 ml water) with stirring. The resultant 5-aminoimidazole-4 carboxamide hydrochloride solution was added slowly, drop-wise, over 20-30 minutes at 0-5° C. After the addition was completed, the reaction mixture was stirred for 10 minutes and filtered. The solid obtained was suspended in 400 ml DM water and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. The obtained solid was suspended in 500 ml of THF and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. Finally, the solid was dried at 45° C. to afford 4-Amino-5-imidazolecarboxamide hydrochloride.

Purification Methods

Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.]

4-Amino-5-imidazolecarboxamide hydrochloride Preparation Products And Raw materials

Raw materials

carbanilic acid Acetamide

Preparation Products

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4-Amino-5-imidazolecarboxamide hydrochloride Suppliers

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View Lastest Price from 4-Amino-5-imidazolecarboxamide hydrochloride manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
4-Amino-5-imidazolecarboxamide hydrochloride 72-40-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98.5%
Supply Ability
500kg
Release date
2022-09-30
airuikechemical co., ltd.
Product
4-Amino-5-imidazole carboxamide hydrochloride 72-40-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-07
Hebei Guanlang Biotechnology Co,.LTD
Product
4-Amino-5-Imidazolecarboxamide Hydrochloride 72-40-2
Price
US $9.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2021-12-21

72-40-2, 4-Amino-5-imidazolecarboxamide hydrochlorideRelated Search:

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