4-Amino-5-imidazolecarboxamide hydrochloride
- Product Name
- 4-Amino-5-imidazolecarboxamide hydrochloride
- CAS No.
- 72-40-2
- Chemical Name
- 4-Amino-5-imidazolecarboxamide hydrochloride
- Synonyms
- AICA;AICA HCL;AIC .cntdot. HCl;AICA HYDROCHLORIDE;TIMTEC-BB SBB003938;5-Amino-1H-imidazoL;LABOTEST-BB LT00440910;e-4-carboxamide hydrochL;Temozolomide intermediate;Dacarbazine EP Impurity B
- CBNumber
- CB5300628
- Molecular Formula
- C4H7ClN4O
- Formula Weight
- 162.58
- MOL File
- 72-40-2.mol
4-Amino-5-imidazolecarboxamide hydrochloride Property
- Melting point:
- 250-252 °C (dec.)(lit.)
- storage temp.
- 2-8°C
- solubility
- water: soluble50mg/mL, clear, light yellow
- form
- Crystals or Crystalline Powder
- color
- White
- Water Solubility
- SOLUBLE
- Sensitive
- Hygroscopic
- BRN
- 3701645
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H
- InChIKey
- MXCUYSMIELHIQL-UHFFFAOYSA-N
- SMILES
- C1(N=CNC=1N)C(=O)N.Cl
- CAS DataBase Reference
- 72-40-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Imidazole-4(5)-carboxamide, 5-(4)-amino-, hydrochloride(72-40-2)
- EPA Substance Registry System
- 1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride (72-40-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- NI3911000
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29332990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 164968
- Product name
- 5-Amino-4-imidazolecarboxamide hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $23.6
- Updated
- 2024/03/01
- Product number
- PHR2304
- Product name
- Dacarbazine Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100MG
- Price
- $534
- Updated
- 2024/03/01
- Product number
- 1162320
- Product name
- Dacarbazine Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1380
- Updated
- 2024/03/01
- Product number
- A1175
- Product name
- 5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $55
- Updated
- 2024/03/01
- Product number
- A1175
- Product name
- 5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $203
- Updated
- 2024/03/01
4-Amino-5-imidazolecarboxamide hydrochloride Chemical Properties,Usage,Production
Chemical Properties
very slightly beige fine powder
Uses
5-Amino-4-imidazolecarboxamide hydrochloride was used in the synthesis of heterocyclic compounds such as guanine, purines and pyrimidines.
General Description
Corrosion inhibition and adsorption characteristics of 5-amino-4-imidazolecarboxamide hydrochloride on aluminum in 1M HCl has been investigated.
Synthesis
47 g of sodium nitrite was dissolved in 1.2 liters of water; The solution was cooled to 0° C. 100 g of 5-aminoimidazole-4 carboxamide was dissolved in a solution of hydrochloric acid (80 ml of 36% HCL in 720 ml water) with stirring. The resultant 5-aminoimidazole-4 carboxamide hydrochloride solution was added slowly, drop-wise, over 20-30 minutes at 0-5° C. After the addition was completed, the reaction mixture was stirred for 10 minutes and filtered. The solid obtained was suspended in 400 ml DM water and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. The obtained solid was suspended in 500 ml of THF and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. Finally, the solid was dried at 45° C. to afford 4-Amino-5-imidazolecarboxamide hydrochloride.
Purification Methods
Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.]
4-Amino-5-imidazolecarboxamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-5-imidazolecarboxamide hydrochloride Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
View Lastest Price from 4-Amino-5-imidazolecarboxamide hydrochloride manufacturers
- Product
- 4-Amino-5-imidazolecarboxamide hydrochloride 72-40-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.5%
- Supply Ability
- 500kg
- Release date
- 2022-09-30
- Product
- 4-Amino-5-imidazole carboxamide hydrochloride 72-40-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
- Product
- 4-Amino-5-Imidazolecarboxamide Hydrochloride 72-40-2
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2021-12-21