Ald-PEG4-t-butyl ester

Ald-PEG4-t-butyl ester Property

Boiling point:

401.7±35.0 °C(Predicted)

Density 

1.059±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

Viscous Liquid

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Ald-PEG4-t-butyl ester Chemical Properties,Usage,Production

Description

Ald-CH2-PEG4-t-butyl ester is a PEG linker that is reactive with aminooxy-containing molecules. The t-butyl ester can be removed under acidic conditions for further conjugation.

Uses

Ald-CH2-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005