ChemicalBook > CAS DataBase List > NSC5844

NSC5844

Product Name
NSC5844
CAS No.
140926-75-6
Chemical Name
NSC5844
Synonyms
RE640;RE 640;RE-640;NSC5844;NSC5844 (RE640);NSC 5844; NSC-5844; RE 640; RE-640; RE640;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844
CBNumber
CB53121123
Molecular Formula
C20H16Cl2N4
Formula Weight
383.27
MOL File
140926-75-6.mol
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NSC5844 Property

Boiling point:
632.6±55.0 °C(Predicted)
Density 
1.431±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form 
A crystalline solid
pka
6.61±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23443
Product name
NSC 5844
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23443
Product name
NSC 5844
Purity
≥95%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
23443
Product name
NSC 5844
Purity
≥95%
Packaging
25mg
Price
$336
Updated
2024/03/01
Cayman Chemical
Product number
23443
Product name
NSC 5844
Purity
≥95%
Packaging
50mg
Price
$593
Updated
2024/03/01
TRC
Product number
B425860
Product name
N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
Packaging
5mg
Price
$65
Updated
2021/12/16
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NSC5844 Chemical Properties,Usage,Production

Description

NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.

Uses

N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.

NSC5844 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC5844 Suppliers

China 64 United States 7 Global 71
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

140926-75-6, NSC5844Related Search:

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  • NSC5844 (RE640)
  • NSC 5844; NSC-5844; RE 640; RE-640; RE640
  • RE 640
  • RE640
  • RE-640
  • NSC5844
  • N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
  • 1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-
  • NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844
  • 140926-75-6