DBCO-PEG5-CH2CH2COOH
- Product Name
- DBCO-PEG5-CH2CH2COOH
- CAS No.
- 2764923-65-9
- Chemical Name
- DBCO-PEG5-CH2CH2COOH
- Synonyms
- DBCO-PEG5-Acid;DBCO-PEG5-CH2CH2COOH;DBCO-NH-PEG5-CH2CH2COOH;4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-
- CBNumber
- CB53339241
- Molecular Formula
- C32H40N2O9
- Formula Weight
- 596.68
- MOL File
- 2764923-65-9.mol
DBCO-PEG5-CH2CH2COOH Property
- solubility
- Soluble in DMSO, DCM, DMF
DBCO-PEG5-CH2CH2COOH Chemical Properties,Usage,Production
Description
DBCO-PEG5-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. DBCO group is a highly reactive cycloalkyne which is commonly used for copper-free Click Chemistry reactions. The hydrophilic PEG chain allows for increased water solubility of compounds in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
DBCO-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG5-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG5-CH2CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DBCO-PEG5-CH2CH2COOH manufacturers
- Product
- DBCO-PEG5-acid 2764923-65-9
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-20