ChemicalBook > CAS DataBase List > 2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine

Product Name
2-Chloro-5-fluoropyrimidine
CAS No.
62802-42-0
Chemical Name
2-Chloro-5-fluoropyrimidine
Synonyms
2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
CBNumber
CB5343151
Molecular Formula
C4H2ClFN2
Formula Weight
132.52
MOL File
62802-42-0.mol
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2-Chloro-5-fluoropyrimidine Property

Boiling point:
149.0-162.0°C
Density 
1.439 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.503(lit.)
Flash point:
150 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Liquid
pka
-2.54±0.22(Predicted)
color 
Clear colorless to yellow
InChI
InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
InChIKey
AGYUQBNABXVWMS-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(F)C=N1
CAS DataBase Reference
62802-42-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-34-41-37/38
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
651753
Product name
2-Chloro-5-fluoropyrimidine
Purity
97%
Packaging
1g
Price
$183
Updated
2023/06/20
Sigma-Aldrich
Product number
651753
Product name
2-Chloro-5-fluoropyrimidine
Purity
97%
Packaging
250mg
Price
$86.8
Updated
2023/01/07
TCI Chemical
Product number
C2546
Product name
2-Chloro-5-fluoropyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
C2546
Product name
2-Chloro-5-fluoropyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$149
Updated
2024/03/01
Alfa Aesar
Product number
H55055
Product name
2-Chloro-5-fluoropyrimidine, 97%
Packaging
1g
Price
$144.65
Updated
2024/03/01
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2-Chloro-5-fluoropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.

Uses

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Preparation

Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

References

[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.
[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).

2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-5-fluoropyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Chloro-5-fluoropyrimidine 62802-42-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-5-fluoropyrimidine 62802-42-0
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-17
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-fluoropyrimidine 62802-42-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26

62802-42-0, 2-Chloro-5-fluoropyrimidineRelated Search:

Cyhalothrin 5-Fluoropyrimidine Fluorocytosine 2-Chloropyrimidine 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE 2,4-DICHLORO-6-ETHYL-5-FLUOROPYRIMIDINE 4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE,4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%,2-Chloro-5-fluoropyrimidine-4-amine 2,4-Dichloro-5-fluoropyrimidine Difluorochloromethane 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Pyrimidine, 4-chloro-6-fluoro- (9CI) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Fluoro-3,5-dichloropyridine 4,6-Dichloro-5-fluoropyrimidine 3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride 4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine CHEMBRDG-BB 4015094

  • Pyrimidine, 2-chloro-5-fluoro- (9CI)
  • 2-CHLORO-5-FLUOROPYRIMIDINE
  • Pyrimidine,2-chloro-5-fluoro-
  • 2-Chloro-5-fluoropyr
  • 2-Chloro-5-fluoropyriMidi...
  • 2-Chloro-5-fluoropyrimidine ,98%
  • 2-Chloro-5-fluoro-1,3-diazine
  • 2-Chloro-5-fluoropyrimidine &gt
  • 2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
  • Fampridine Impurity 213
  • 62802-42-0
  • 63802-42-0
  • C4H2ClFN2
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Fluorine series
  • Bases & Related Reagents
  • Nucleotides
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PyrimidinesHeterocyclic Building Blocks
  • Variety of halogenated heterocyclic series
  • PYRIMIDINE
  • Pyrimidine series
  • pharmacetical
  • Pyrimidines
  • 62802-42-0