Ethyl oxazole-4-carboxylate
- Product Name
- Ethyl oxazole-4-carboxylate
- CAS No.
- 23012-14-8
- Chemical Name
- Ethyl oxazole-4-carboxylate
- Synonyms
- ETHYL 4-OXAZOLECARBOXYLATE;4-Oxa;4-OxazoL;4-ethoxycarbonyloxazole;ETHYL OXAZOLE-4-CARBOXYLATE;Ethyl4-Oxazolecarboxylate>4-(Ethoxycarbonyl)-1,3-oxazole;Ethyl 4-oxazolecarboxylate 97%;Ethyl 1,3-oxazole-4-carboxylate;Ethyl 1,3-oxazole-4-carboxylate 97%
- CBNumber
- CB5397765
- Molecular Formula
- C6H7NO3
- Formula Weight
- 141.12
- MOL File
- 23012-14-8.mol
Ethyl oxazole-4-carboxylate Property
- Melting point:
- 48°C
- Boiling point:
- 101°C 14mm
- Density
- 1.177 g/mL at 25 °C
- refractive index
- n20/D 1.467
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- pka
- 0.38±0.10(Predicted)
- color
- White or Colorless to Almost white or Almost colorless
- InChI
- InChI=1S/C6H7NO3/c1-2-10-6(8)5-3-9-4-7-5/h3-4H,2H2,1H3
- InChIKey
- UBESIXFCSFYQNK-UHFFFAOYSA-N
- SMILES
- O1C=C(C(OCC)=O)N=C1
- CAS DataBase Reference
- 23012-14-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 696625
- Product name
- Ethyl 4-oxazolecarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $81.5
- Updated
- 2023/06/20
- Product number
- O0289
- Product name
- Ethyl 4-Oxazolecarboxylate
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- O0289
- Product name
- Ethyl 4-Oxazolecarboxylate
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- E926508
- Product name
- EthylOxazole-4-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR3767
- Product name
- Ethyl1,3-oxazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
Ethyl oxazole-4-carboxylate Chemical Properties,Usage,Production
Uses
Used for the Palladium-Catalyzed Synthesis of (Hetero)aryloxazoles.[1]
Synthesis
2949-22-6
23012-14-8
The general procedure for the synthesis of ethyl oxazole-4-carboxylate from ethyl isocyanoylacetate was as follows: formic acid (8.62 mL, 228 mmol) was added in batches to anhydrous THF (200 mL), and the phenomenon of gas escape was observed. The mixture was stirred for 30 min to form a sol. Subsequently, a solution of ethyl isocyanoacetate (25 mL, 228 mmol) and triethylamine (Et3N, 60.5 mL, 434 mmol) was added to the reaction mixture. The mixture was stirred at room temperature for 1 hour and then changed to reflux conditions overnight. After the reaction was completed, the mixture was cooled to room temperature. Water was added and the mixture was extracted with ether (Et2O, 3 times). The organic phases were combined, dried with magnesium sulfate (MgSO4), filtered and concentrated. The residue was purified by fast column chromatography (FC, eluent: ethyl acetate/heptane, ratio graded from 1:5 to 1:3 and finally to 1:1) to afford ethyl oxazole-4-carboxylate (27.2 g, 84% yield). LC-MS analysis resulted in a retention time (tR) = 0.58 min and a mass-to-charge ratio in the electrosprayed positive ion mode (ES+) (m/z) = 142.07 .
References
[1] CéCILE VERRIER. Palladium-Catalyzed Direct (Hetero)arylation of Ethyl Oxazole-4-carboxylate: An Efficient Access to (Hetero)aryloxazoles[J]. The Journal of Organic Chemistry, 2008, 73 18: 7383-7386. DOI:10.1021/jo801093n.
Ethyl oxazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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- Switzerland
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View Lastest Price from Ethyl oxazole-4-carboxylate manufacturers
- Product
- Ethyl oxazole-4-carboxylate 23012-14-8
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- Ethyl 4-Oxazolecarboxylate 23012-14-8
- Price
- US $680.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-02-29
- Product
- Ethyl oxazole-4-carboxylate 23012-14-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27