Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine

ChemicalBook > CAS DataBase List > Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine

Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine

Product Name: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
CAS No.: 607366-20-1
Chemical Name: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
Synonyms: FMOC-DAP(IVDDE)-OH;FMOC-DPR(IVDDE)-OH;FMOC-L-DAP(IVDDE)-OH;N-α-Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1;Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine;3-[1-(4,4-DiMethyl-2,6-dioxocyclohexylidene)-3-MethylbutylaMino]-FMoc-L-alanine, 95%;Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine USP/EP/BP;FMoc-Nβ-(4,4-diMethyl-2,6-dioxocyclohex-1-ylidene)-3-Methylbutyl-L-2,3-diaMinopropionic acid;Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid;Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid
CBNumber: CB5413560
Molecular Formula: C31H36N2O6
Formula Weight: 532.63
MOL File: 607366-20-1.mol

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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Property

Boiling point:: 733.7±60.0 °C(Predicted)
Density: 1.221
storage temp.: Store at -15°C to -25°C.
pka: 3.47±0.10(Predicted)

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52083
Product name: Fmoc-Dpr(ivDde)-OH
Purity: Novabiochem?
Packaging: 1G
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52083
Product name: Fmoc-Dpr(ivDde)-OH
Purity: Novabiochem?
Packaging: 5G
Price: $713
Updated: 2024/03/01

TRC

Product number: F621080
Product name: N-α-Fmoc-N-β-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicAcid
Packaging: 1g
Price: $335
Updated: 2021/12/16

TRC

Product number: F621080
Product name: N-α-Fmoc-N-β-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicAcid
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 07105
Product name: Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionicacid,98-100%(Assaybytitration)
Purity: 98-100%(Assaybytitration)
Packaging: 250MG
Price: $95.76
Updated: 2021/12/16

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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Chemical Properties,Usage,Production

Uses

N-alpha-Fmoc-N-beta-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic Acid is used in the synthesis of phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. It is also used to prepare peptidomimetic ligands for α4β1 integrin on Jurkat T-leukemia cells.

General Description

This orthogonally-protected diaminopropionic acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1]. However, migration from side-chain to the unprotected α-amino group of Dpr is unavoidable [2]. This side-reaction can, however, be minimized by the appropriate choice of coupling method for the subsequent residue, see [3].

When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [4].

The product number for this product was previously 04-12-1195.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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607366-20-1, Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanineRelated Search:

Fmoc-O-trityl-L-serine Dimethyl sulfide Dimethyl ether D-Alanine p-Anisaldehyde p-Anisidine 3-(METHOXYMETHOXY)BENZALDEHYDE Dacthal Phenprobamate (Trifluoromethoxy)benzene ETHANE EC 2.6.1.2 4-Methoxyphenylacetic acid N,N-Dimethylformamide Dimethyl carbonate Fmoc-8-amino-3,6-dioxaoctanoic acid Dimethyl sulfate Dimethyl sulfoxide

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL)-L-2,3-DIAMINOPROPIONIC ACID

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-BETA-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-2,3-DIAMINOPROPIONIC ACID

N-ALPHA-FMOC-N-BETA-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-DIAMINOPROPIONIC ACID

3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

FMOC-N-BETA-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-2,3-DIAMINOPROPIONIC ACID

FMOC-DPR(IVDDE)-OH

FMOC-DAP(IVDDE)-OH

FMOC-L-DAP(IVDDE)-OH

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)propanoic acid

N2-Fmoc-N3-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid

FMoc-Nβ-(4,4-diMethyl-2,6-dioxocyclohex-1-ylidene)-3-Methylbutyl-L-2,3-diaMinopropionic acid

Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine

3-[1-(4,4-DiMethyl-2,6-dioxocyclohexylidene)-3-MethylbutylaMino]-FMoc-L-alanine, 95%

Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid

(2S)-3-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

L-Alanine, 3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine USP/EP/BP

Nα-Fmoc-Nβ-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic acid

N-α-Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1

607366-20-1

amino acid

amino acids