EC 4.2.1.2
Description Source Background- Product Name
- EC 4.2.1.2
- CAS No.
- 9032-88-6
- Chemical Name
- EC 4.2.1.2
- Synonyms
- MCL;LRCC;MPCL;MCUL1;CLEC6;CLEC-6;CLECSF8;FUMARASE;EC 4.2.1.2;Fumarase human
- CBNumber
- CB5474419
- Formula Weight
- 0
- MOL File
- Mol file
EC 4.2.1.2 Property
- storage temp.
- 2-8°C
- form
- ammonium sulfate suspension
- Specific Activity
- ≥300units/mg protein (biuret)
- EPA Substance Registry System
- Hydratase, fumarate (9032-88-6)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F1757
- Product name
- Fumarase from porcine heart
- Purity
- ammonium sulfate suspension, 300-500?units/mg protein (biuret)
- Packaging
- 500units
- Price
- $538
- Updated
- 2025/07/31
- Product number
- F1757
- Product name
- Fumarase from porcine heart
- Purity
- ammonium sulfate suspension, 300-500?units/mg protein (biuret)
- Packaging
- 2500Units
- Price
- $2280
- Updated
- 2025/07/31
- Product number
- F1757
- Product name
- Fumarase from porcine heart
- Purity
- ammonium sulfate suspension, 300-500?units/mg protein (biuret)
- Packaging
- 5000units
- Price
- $3440
- Updated
- 2025/07/31
- Product number
- SRP6120
- Product name
- Fumarase human
- Purity
- recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
- Packaging
- 100μG
- Price
- $419
- Updated
- 2023/01/07
- Product number
- ENZ0000815
- Product name
- FUMARASE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.02
- Updated
- 2021/12/16
EC 4.2.1.2 Chemical Properties,Usage,Production
Uses
Fumarase from porcine heart has been used:
- as a positive control in isocitrate dehydrogenase and α-ketoglutarate dehydrogenase assay
- for immobilized enzyme based stability assay
- in fumarate hydratase assays in human lung carcinoma cells (A549)
Definition
An enzyme that catalyzes the interconversion of fumaric acid and malic acid. It is an important reactant in the tricarboxylic acid cycle.
General Description
Fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme found in both the cytoplasm and mitochondria of all eukaryotes.
Biochem/physiol Actions
Fumarase catalyzes the reversible hydration of fumarate to malate. In its mitochondrial form, fumarate is involved in the Krebs Cycle, while the cytosolic form is involved in amino acid metabolism.
Description
Fumarase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 467 amino acids (44-510) and having a molecular mass of 50.2 kDa.
Fumarate Hydratase is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Fumarase is an enzymatic factor of Krebs cycle, which catalyzes the formation of L-malate from fumarate. Fumarase exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is aimed to the mitochondrion, where the removal of the extension results in the same form as in the cytoplasm. Fumarase is similar to a number of thermostable Class-2 fumarases and functions as a homotetramer. Mutations in the Fumarase gene causes fumarase deficiency and leads to progressive encephalopathy, cerebral atrophy and developmental delay. Fumarase enzyme is also thought to act as a tumor suppressor. Leydig cell tumors are caused by Fumarase mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor.
EC 4.2.1.2 Preparation Products And Raw materials
Raw materials
Preparation Products
EC 4.2.1.2 Suppliers
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