2,4-Dihydroxybenzophenone

ChemicalBook > CAS DataBase List > 2,4-Dihydroxybenzophenone

2,4-Dihydroxybenzophenone

pollution

Product Name: 2,4-Dihydroxybenzophenone
CAS No.: 131-56-6
Chemical Name: 2,4-Dihydroxybenzophenone
Synonyms: BP-1;UV-0;BENZOPHENONE-1;Uv 12;BENZORESORCINOL;uv12;4-BENZORESORCINOL;hhb;uf1;Uf 1
CBNumber: CB5475441
Molecular Formula: C13H10O3
Formula Weight: 214.22
MOL File: 131-56-6.mol

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2,4-Dihydroxybenzophenone Property

Melting point:: 144.5-147 °C(lit.)
Boiling point:: 194 °C (1 mmHg)
Density: 1,32 g/cm³
vapor pressure: 0Pa at 25℃
refractive index: 1.5090 (estimate)
Flash point:: 125 °C
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
pka: 7.72±0.35(Predicted)
form: Crystalline Powder
color: Yellow
PH: 5 (10g/l, H2O, 20℃)(slurry)
Water Solubility: insoluble
Merck: 14,1106
BRN: 1311566
InChIKey: ZXDDPOHVAMWLBH-UHFFFAOYSA-N
LogP: 2.964 at 25℃
CAS DataBase Reference: 131-56-6(CAS DataBase Reference)
NIST Chemistry Reference: Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA Substance Registry System: Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36-36/37/38-61
Safety Statements: 26-37/39-45-53
WGK Germany: 2
RTECS: DJ0700000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29145000
Hazardous Substances Data: 131-56-6(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: > 5000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SRP5162
Product name: 4EBP1, His tagged human
Purity: recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Packaging: 50μG
Price: $349
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18652
Product name: 2,4-Dihydroxybenzophenone
Purity: for synthesis
Packaging: 250g
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: 126217
Product name: 2,4-Dihydroxybenzophenone
Purity: 99%
Packaging: 100g
Price: $45.3
Updated: 2024/03/01

TCI Chemical

Product number: D0573
Product name: 2,4-Dihydroxybenzophenone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $20
Updated: 2024/03/01

TCI Chemical

Product number: D0573
Product name: 2,4-Dihydroxybenzophenone
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $153
Updated: 2024/03/01

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2,4-Dihydroxybenzophenone Chemical Properties,Usage,Production

pollution

Benzophenones (BPs), as UV filters, are widely utilized in personal care products such as sunscreen, body lotion and plastic products. 2,4-Dihydroxybenzophenone (BP-1) is a representative type of BP that has attracted wide attention owing to the high residues in the aquatic environment. According to previous studies, this compound can enter the aquatic environment through recreational water activities or incomplete removal in wastewater treatment plants (WWTPs). For example, BP-1 has been widely detected in seawater, groundwater, river water and WWTP effluents in Spain at concentrations ranging from 4.2 ng/L to 722.0 ng/L. More seriously, because of extensive human exposure through plastic products and sunscreen cosmetics, BP-1 has been detected in human urine, blood and milk[1].

Description

2,4-Dihydroxybenzophenone (DHP) is an organic compound derived from Garcinia xanthochymus, but there have been no reports on its biochemical functions and bioavailability. 2,4-dihydroxybenzophenone has been prepared by reacting resorcinol with benzoyl chloride or benzoic acid under anhydrous conditions in the presence of Friedel-Crafts catalysts such as AlCl3 or ZnCl2[1].

Chemical Properties

yellow crystalline powder

Uses

Novel mordent and disperse azo dyes were prepared by the coupling of various diazo solutions of aromatic amines with 2, 4-dihydroxybenzophenone. The ultraviolet absorbing monomers were synthesized by reaction of 2, 4-dihydroxybenzophenone with glycidyl acrylate and glycidyl methacrylate. Two new polymerizable stabilizers, 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and corresponding methacrylate (BPBHMA), were synthesized and characterized from 2,4-Dihydroxybenzophenone. a polymerizable UV-stabilizer, 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), was synthesized using 2, 4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA).

Uses

2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.

Uses

Ultraviolet light absorber, especially in paints and plastics.

Definition

ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Biological Activity

2,4-Dihydroxybenzophenone has potential effects on the stimulation of osteoblast differentiation and mitigate PDS-induced osteoporosisthrough the activation of the β-catenin pathway. Moreover, 2,4-Dihydroxybenzophenone demonstrated a capacity to enhance the expression of crucial osteogenic markers, including RUNX2, OSX, and ALP[2].

Contact allergens

BZP-1 is used, for example, in paints, plastics, and nail varnishes.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicology

As a persistent and bioaccumulative compound, 2,4-Dihydroxybenzophenone (BP-1) exhibits estrogenic activity or anti-androgenic activity in vitro, which could pose potential risks to the ecological environment and human health. At present, there are a large amount of reports that concentrated on the biotoxicity of BP-1, mainly focusing on its endocrine disrupting effects and genetic toxicity. Endocrine-toxicological studies have shown that the toxicity of BP-1 is five times that of bisphenol A (BPA)[2].

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

References

[1] Mengting Zou . “Effective degradation of 2,4-dihydroxybenzophenone by zero–valent iron powder (Fe0)-activated persulfate in aqueous solution: Kinetic study, product identification and theoretical calculations.” Science of the Total Environment 771 (2021): Article 144743.
[2] Mirissa Hewage Dumindu Kavinda and & Gi-Young Kim*. “2,4′-Dihydroxybenzophenone Exerts Bone Formation and Antiosteoporotic Activity by Stimulating the β-Catenin Signaling Pathway.” ACS Pharmacology and Translational Science 7 2 (2024): 395–405.

2,4-Dihydroxybenzophenone Preparation Products And Raw materials

Raw materials

Phenol Resorcinol Benzotrichloride Benzoyl chloride

Preparation Products

2-(4-Benzoyl-3-hydroxyphenoxy)ethyl acrylate Octabenzone Fluotrimazol 2-METHYL-ACRYLIC ACID-2-(4-BENZOYL-3-HYDROXY-PHENOXY)-ETHYL ESTER

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View Lastest Price from 2,4-Dihydroxybenzophenone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: UV ABSORBER UV-0 131-56-6
Price: US $80.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-06-04

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: UV Absorber Benzophenone-1 UV-0 131-56-6
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-28

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,4-Dihydroxybenzophenone 131-56-6
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-11-04

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