Propargyl-PEG6-azide
- Product Name
- Propargyl-PEG6-azide
- CAS No.
- 1198080-03-3
- Chemical Name
- Propargyl-PEG6-azide
- Synonyms
- Propargyl-PEG6-N3;Azido-PEG6-propargyl;Propargyl-PEG6-azide;1-Azido-3,6,9,12,15,18-hexaoxahenicos-20-yne;3,6,9,12,15,18-Hexaoxaheneicos-20-yne, 1-azido-;3-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne
- CBNumber
- CB54849648
- Molecular Formula
- C15H27N3O6
- Formula Weight
- 345.4
- MOL File
- 1198080-03-3.mol
Propargyl-PEG6-azide Property
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Propargyl-PEG6-azide Chemical Properties,Usage,Production
Uses
Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Propargyl-PEG6-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG6-azide manufacturers
- Product
- Propargyl-PEG6-N3 1198080-03-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26