Propargyl-PEG6-azide

Product Name: Propargyl-PEG6-azide
CAS No.: 1198080-03-3
Chemical Name: Propargyl-PEG6-azide
Synonyms: Propargyl-PEG6-N3;Azido-PEG6-propargyl;Propargyl-PEG6-azide;1-Azido-3,6,9,12,15,18-hexaoxahenicos-20-yne;3,6,9,12,15,18-Hexaoxaheneicos-20-yne, 1-azido-;3-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne
CBNumber: CB54849648
Molecular Formula: C15H27N3O6
Formula Weight: 345.4
MOL File: 1198080-03-3.mol

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Propargyl-PEG6-azide Property

storage temp.: Storage temp. 2-8°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Propargyl-PEG6-azide Chemical Properties,Usage,Production

Uses

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG6-azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG6-azide Suppliers

China 26 United States 2 Global 28

Borenpharm Co., Ltd

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SHANGHAI FDC-CHEMICAL CO.,LTD

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Wuhan Borenpharm Co., Ltd

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Shanghai Minhan Pharmaceutical Technology Co., Ltd.

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View Lastest Price from Propargyl-PEG6-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG6-N3 1198080-03-3
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-26

1198080-03-3, Propargyl-PEG6-azideRelated Search:

Propargyl-PEG6-NHS ester Propargyl-PEG6-t-butyl ester

Propargyl-PEG6-azide

Azido-PEG6-propargyl

Propargyl-PEG6-N3

3,6,9,12,15,18-Hexaoxaheneicos-20-yne, 1-azido-

1-Azido-3,6,9,12,15,18-hexaoxahenicos-20-yne

3-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne

1198080-03-3