Azido-PEG1-CH2CO2-NHS
- Product Name
- Azido-PEG1-CH2CO2-NHS
- CAS No.
- 1480545-09-2
- Chemical Name
- Azido-PEG1-CH2CO2-NHS
- Synonyms
- N3-PEG1-CH2COO-NHS;Azido-PEG1-CH2COONHS;Azido-PEG1-CH2CO2-NHS;Azido-Peg1-CH2CO2-NH3;Azido-PEG1-CH2COO-NHS ester;Azido-PEG1-CH2COOH NHS Ester;2,5-dioxopyrrolidin-1-yl 2-(2-azidoethoxy)acetate
- CBNumber
- CB23373563
- Molecular Formula
- C8H10N4O5
- Formula Weight
- 242.19
- MOL File
- 1480545-09-2.mol
Azido-PEG1-CH2CO2-NHS Property
- solubility
- Soluble in DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- BP-24047
- Product name
- Azido-PEG1-CH2CO2-NHS
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-24047
- Product name
- Azido-PEG1-CH2CO2-NHS
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
Azido-PEG1-CH2CO2-NHS Chemical Properties,Usage,Production
Description
Azido-PEG1-CH2CO2-NHS is a PEG linker containing azide and NHS ester moieties. The hydrophilic PEG spacer increases the water solubility of compounds in aqueous media. The azide group can react with alkynes, BCN and DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Uses
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG1-CH2CO2-NHS Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG1-CH2CO2-NHS Suppliers
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View Lastest Price from Azido-PEG1-CH2CO2-NHS manufacturers
- Product
- N3-PEG1-CH2COO-NHS 1480545-09-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-04