Azido-PEG1-methylamine

Product Name: Azido-PEG1-methylamine
CAS No.: 1835759-88-0
Chemical Name: Azido-PEG1-methylamine
Synonyms: Azido-PEG1-methylamine;Azido-PEG1-C2-methylamine;2-(2-Azidoethoxy)-N-methylethanamine;2-(2-azidoethoxy)-N-methylethanamine HCl
CBNumber: CB43162862
Molecular Formula: C5H12N4O
Formula Weight: 144.18
MOL File: 1835759-88-0.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22931
Product name: Azido-PEG1-methylamine
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-22931
Product name: Azido-PEG1-methylamine
Purity: 98%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

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Azido-PEG1-methylamine Chemical Properties,Usage,Production

Description

Azido-PEG1-methylamine contain an azide group and methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Azido-PEG1-C2-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C2-methylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG1-methylamine Preparation Products And Raw materials

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Azido-PEG1-methylamine Suppliers

China 15 United States 2 Global 17

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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1835759-88-0, Azido-PEG1-methylamineRelated Search:

Ald-PEG5-Azide Azido-PEG1-methyl ester Azido-PEG1-CH2CO2-NHS Azido-PEG3-methyl ester Azido-PEG7-acid Azido-PEG5-PFP ester Azide-PEG7-Tos Azido-PEG4-beta-D-glucose Azidoethyl-SS-ethylamine

Azido-PEG1-methylamine

2-(2-azidoethoxy)-N-methylethanamine HCl

Azido-PEG1-C2-methylamine

2-(2-Azidoethoxy)-N-methylethanamine

1835759-88-0