Azido-PEG3-methyl ester
- Product Name
- Azido-PEG3-methyl ester
- CAS No.
- 2086689-07-6
- Chemical Name
- Azido-PEG3-methyl ester
- Synonyms
- N3-PEG3-COOMe;Azido-PEG3-methyl ester;methyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate;Methyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate , Azido-PEG3-methyl ester
- CBNumber
- CB43373567
- Molecular Formula
- C10H19N3O5
- Formula Weight
- 261.28
- MOL File
- 2086689-07-6.mol
N-Bromosuccinimide Price
- Product number
- BP-23517
- Product name
- Azido-PEG3-methylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- P1013-00-N
- Product name
- methyl3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $298
- Updated
- 2021/12/16
Azido-PEG3-methyl ester Chemical Properties,Usage,Production
Description
Azido-PEG3-methyl ester is a click chemistry reagent with an azide(N3) and methyl ester moieties. The azide group can react with alkynes in copper-free Click Chemistry reactions. Methyl ester can be hydrolyzed under strong basic condition. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Uses
Azido-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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