Azido-PEG5-PFP ester

Product Name: Azido-PEG5-PFP ester
CAS No.: 1818294-48-2
Chemical Name: Azido-PEG5-PFP ester
Synonyms: N3-PEG5-CH2CH2COOPFP;(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CBNumber: CB53062365
Molecular Formula: C19H24F5N3O7
Formula Weight: 501.41
MOL File: 1818294-48-2.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21863
Product name: Azido-PEG5-PFPester
Purity: 98%
Packaging: 250mg
Price: $460
Updated: 2021/12/16

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Azido-PEG5-PFP ester Chemical Properties,Usage,Production

Description

Azido-PEG5-PFP ester is a linker compound containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.

Uses

Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG5-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Alkyl/ether

References

[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228

Azido-PEG5-PFP ester Preparation Products And Raw materials

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Azido-PEG5-PFP ester Suppliers

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1818294-48-2, Azido-PEG5-PFP esterRelated Search:

Azido-PEG3-PFP ester Azido-PEG1-PFP ester Azido-PEG8-PFP ester Azido-PEG6-PFP ester Azido-PEG4-TFP ester Ald-PEG5-Azide Azido-PEG1-methyl ester Azido-PEG1-CH2CO2-NHS Azido-PEG1-methylamine Azido-PEG3-methyl ester Azido-PEG7-acid Azide-PEG7-Tos Azido-PEG4-beta-D-glucose Azidoethyl-SS-ethylamine

(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate

N3-PEG5-CH2CH2COOPFP

1818294-48-2