Azido-PEG3-aldehyde
- Product Name
- Azido-PEG3-aldehyde
- CAS No.
- 1807530-10-4
- Chemical Name
- Azido-PEG3-aldehyde
- Synonyms
- N3-PEG3-CHO;N3-PEG3-ALD;N3-PEG3-CH2CH2CHO;Azido-PEG3-aldehyde;3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanal
- CBNumber
- CB53062350
- Molecular Formula
- C9H17N3O4
- Formula Weight
- 231.25
- MOL File
- 1807530-10-4.mol
Azido-PEG3-aldehyde Property
- form
- Liquid
- color
- Colorless to off-white
Azido-PEG3-aldehyde Chemical Properties,Usage,Production
Uses
Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
Azido-PEG3-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Azido-PEG3-aldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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