Indoline

Product Name: Indoline
CAS No.: 496-15-1
Chemical Name: Indoline
Synonyms: Dihydroindole;2,3-DIHYDRO-1H-INDOLE;2,3-DIHYDROINDOLE;1H-Indole, 2,3-dihydro-;IDN;NDOLINE;INDOLINE;1-Azaindan;1H-Indoline;Indoline>
CBNumber: CB5485525
Molecular Formula: C8H9N
Formula Weight: 119.16
MOL File: 496-15-1.mol

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Indoline Property

Melting point:: -21 °C
Boiling point:: 220-221 °C (lit.)
Density: 1.063 g/mL at 25 °C (lit.)
refractive index: n20/D 1.592(lit.)
Flash point:: 199 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 5g/l; lnsoluble in water, soluble in alcohol and oils. Poorly soluble in Propylene glycol.
pka: 5.20±0.20(Predicted)
form: liquid (clear)
color: clear dark brown
Odor: a mild, delicate, but extremely tenacious floral odor
Water Solubility: 5 g/L (20 ºC)
Sensitive: Light Sensitive
BRN: 111915
CAS DataBase Reference: 496-15-1(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Indole, 2,3-dihydro-(496-15-1)
EPA Substance Registry System: 1H-Indole, 2,3-dihydro- (496-15-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-37/39-26
WGK Germany: 3
RTECS: NL6906300
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I5605
Product name: Indoline
Purity: ReagentPlus , 99%
Packaging: 25g
Price: $40.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: I5605
Product name: Indoline
Purity: ReagentPlus , 99%
Packaging: 100g
Price: $71.4
Updated: 2024/03/01

TCI Chemical

Product number: I0033
Product name: Indoline
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: I0033
Product name: Indoline
Purity: >98.0%(GC)(T)
Packaging: 250mL
Price: $191
Updated: 2024/03/01

Alfa Aesar

Product number: A11000
Product name: Indoline, 99%
Packaging: 50g
Price: $61.7
Updated: 2024/03/01

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Indoline Chemical Properties,Usage,Production

Chemical Properties

?2,3-Dihydroindole [496-15-1], indoline C8H9N, Mr 119.16, bp 229 – 230 ℃(101.3 kPa), is a colorless liquid, which is volatile in steam and soluble in diethyl ether, acetone, and benzene, but only slightly soluble in water. Indoline is obtained by hydrogenation of indole or by catalytic cyclodehydration of 2-(2-aminophenyl)ethanol. A range of pharmaceuticals, as well as fungicides and bactericides, can be produced from indoline.

Uses

As an indole derivative, Indoline can be used in the preparation of various medicinal compounds such as potential α1-adrenoceptor (α1-AR) antagonists.

Uses

Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines.

Uses

Reactant for preparation of:

Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
Sphingosine-1-phosphate 4(S1P4) receptor antagonists
Cytotoxic cell cycle inhibitors
2-Aminopyridines
PET agent for imaging of protein kinase C (PKC)
Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
α4β2-Nicotinic acetylcholine receptor-selective partial agonists
mGlu4 positive allosteric modulators
Bacterial biofilm inhibitors
Serotonin 5-HT6 receptor antagonists

Definition

ChEBI: Indoline is a member of indoles.

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 7812, 1974 DOI: 10.1021/ja00832a035
Synthetic Communications, 13, p. 489, 1983 DOI: 10.1080/00397918308081827

Synthesis

Indolene is manufactured from (theoretically) 2 Mol. Indole plus 1 Mol. Hydroxycitronellal by condensation under heating. The proportions may vary slightly, and it is common practice to add Diethyl phthalate to the mixture prior to heating, so that the condensation product is somewhat protected against local overheating, and the finished product becomes light of color and fairly pourable at room temperature.

Indoline Preparation Products And Raw materials

Raw materials

Preparation Products

2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID 5-CYANO-2,3-DIHYDRO-1H-INDOLE 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE 1-Acetyl-5-bromoindoline 5-AMINOINDOLE HYDROCHLORIDE INDOLINE-7-CARBOXYLIC ACID 5-BROMOINDOLINE 6-bromoindoline 6-Nitroindole 1-ACETYL-5-NITROINDOLINE 6-Aminoindole Indole 4-Bromo-2,3-dihydro-1H-indole 7-bromoindoline

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Indoline Suppliers

Americas 1 Austria 1 Belgium 3 Canada 1 China 335 Europe 5 France 1 Germany 10 India 23 Italy 1 Japan 11 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 2 United Kingdom 23 United States 54 Global 477

Molekula Limited

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LEHVOSS UK / Gee Lawson Chemical Division

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Fisher Scientific Uk Ltd.

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Apollo Scientific Ltd

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Melrob Ltd (part of Nordmann)

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NiCHe Materials Ltd.

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Whyte Chemicals

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Manchester Organics

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CMS Chemicals Limited

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Apollo Scientific Ltd.

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Apin Chemicals Limited (UK)

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Leancare Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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Eurolabs Limited

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Atlantic Research Chemicals Ltd.

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MOLEKULA Ltd.

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UK GREEN SCIENTIFIC CO.,LIMITED

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Fluorochem Ltd.

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Apin Chemicals Ltd.

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VWR International

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MDA Chemicals Ltd.

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Gee Lawson Ltd.

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Zerenex Molecular Limited

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View Lastest Price from Indoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Indoline 496-15-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%-100.00%
Supply Ability: 200kg/month
Release date: 2021-06-01

Hebei Weibang Biotechnology Co., Ltd

Product: Indoline 496-15-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-09-09

Shaanxi Dideu Medichem Co. Ltd

Product: Indoline 496-15-1
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2019-12-30

496-15-1, IndolineRelated Search:

Indometacin cis-Octahydro-isoindole Dihydromyrcenol Indoline-2-carboxylic acid Indole-3-butyric acid Indole-3-acetic acid 2-Methylindoline Indole INDOXYL ACETATE AIDS124803 METHYL 2-INDOLINECARBOXYLATE Indoline-3-carboxylic acid 2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Indazole Indobufen Indocyanine green Indole-3-carbinol INDOLAROME

Indoline in stock Factory

2,3-dihydro-1h-indol

Dihydroindole

2,3-DIHYDROINDOLE

2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE

2,3-DIHYDRO-1H-INDOLE

LABOTEST-BB LT01605668

TIMTEC-BB SBB004291

INDOLINE

IDN

Indoline.2.3-Dihydroindole

2,3-Dichloro-1H-Indole

Indoline,98%

1H-Indole, 2,3-dihydro-

Indoline ,97%

1-Azaindan

2,3-Dihydro-1H-indole, 1-Azaindan

Indoline, 98% 100GR

Indoline, 98% 25GR

1H-Indoline

INDOLINE FOR SYNTHESIS 25 ML

Two hydrogenindole

Indoline ReagentPlus(R), 99%

Indoline Vetec(TM) reagent grade, 98%

Indoline&gt

Bromfenac Impurity 40

NDOLINE

2-(3-(4-bromobenzoyl)-2-nitrophenyl)acetic acid

496-15-1

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