ChemicalBook > CAS DataBase List > DMT-2'O-Methyl-rU Phosphoramidite
DMT-2'O-Methyl-rU Phosphoramidite
- Product Name
- DMT-2'O-Methyl-rU Phosphoramidite
- CAS No.
- 110764-79-9
- Chemical Name
- DMT-2'O-Methyl-rU Phosphoramidite
- Synonyms
- 2'-OMe-U amidite;2’-OMe -dU Amidite;5'-O-DMT-2'-OMe-U-CE;Cytidine Impurity 15;2'-OMe-Uridine Amidite;2'-OMe-Uridine Amidite;2'-OMe-U Phosphoramidite;2'-OMe-rU Phosphoramidite;2'-OMe-U-CE-Phosphoramidite;5'-O-DMT-2'-O-Me-rU-3'-CEDPA
- CBNumber
- CB5500323
- Molecular Formula
- C40H49N4O9P
- Formula Weight
- 760.82
- MOL File
- 110764-79-9.mol
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DMT-2'O-Methyl-rU Phosphoramidite Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO : 100 mg/mL (131.44 mM; Need ultrasonic)
- form
- powder
- pka
- 9.39±0.10(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/s3
- InChIKey
- UVUOJOLPNDCIHL-XKZJCBTISA-N
- SMILES
- C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,36,39,r|
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- U211180
- Product name
- DMT-2′O-Methyl-rU Phosphoramidite
- Purity
- configured for PerkinElmer, configured for Polygen
- Packaging
- 1G
- Price
- $81.4
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- U211150
- Product name
- DMT-2′O-Methyl-rU Phosphoramidite
- Purity
- configured for ?KTA? and OligoPilot?
- Packaging
- 2g
- Price
- $181
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- U211100
- Product name
- DMT-2′O-Methyl-rU Phosphoramidite
- Purity
- ≥99% (31P-NMR)
- Packaging
- 500g
- Price
- $32550
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- U211100
- Product name
- DMT-2′O-Methyl-rU Phosphoramidite
- Purity
- ≥99% (31P-NMR)
- Packaging
- 100g
- Price
- $8080
- Updated
- 2022/05/15
Sigma-Aldrich
- Product number
- U211180
- Product name
- DMT-2′O-Methyl-rU Phosphoramidite
- Purity
- configured for PerkinElmer, configured for Polygen
- Packaging
- 0.5g
- Price
- $92.7
- Updated
- 2024/03/01
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DMT-2'O-Methyl-rU Phosphoramidite Chemical Properties,Usage,Production
Characteristics
DMT-2′O-Methyl-rU Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. Its key features include:
High yield of crude oligonucleotides Compatible with DNA synthesis;
Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides;
Recommended deprotection conditions are 8 hours at 55 deg C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 deg C;
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation;
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers);
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry.
Uses
DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.
Application
2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rU Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
DMT-2'O-Methyl-rU Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
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DMT-2'O-Methyl-rU Phosphoramidite Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6581
- Advantage
- 61
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View Lastest Price from DMT-2'O-Methyl-rU Phosphoramidite manufacturers
Hefei Huana Biomedical Technology Co.,Ltd.
- Product
- 5'-O-DMT-2'-OMe-U-CE 110764-79-9
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2023-03-09
R&D Scientific Inc.
- Product
- 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite 110764-79-9
- Price
- US $600.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-02-11
SHANGHAI NOVRIBO BIOTECH
- Product
- 2'-OMe-U CE Phosphoramidite 110764-79-9
- Price
- US $100.00/kg
- Min. Order
- 0.009999999776482582kg
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2023-03-20
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