ChemicalBook > CAS DataBase List > Methyl pyrrolidine-2-carboxylate hydrochloride

Methyl pyrrolidine-2-carboxylate hydrochloride

Product Name
Methyl pyrrolidine-2-carboxylate hydrochloride
CAS No.
65365-28-8
Chemical Name
Methyl pyrrolidine-2-carboxylate hydrochloride
Synonyms
D-PRO-OME;H-D-Pro-OMe;96.0%(N&D-Pro-Ome.Hcl;H-D-PRO-OME HCL;D-PROLINE-OME HCL;Methyl pyrrolidine-2;H-D-Pro-OMe·HCl (Solid);D-PROLINE METHYL ESTER HCL;METHYL D-PROLINATE HYDROCHLORIDE
CBNumber
CB5675050
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
65365-28-8.mol
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Methyl pyrrolidine-2-carboxylate hydrochloride Property

Melting point:
69-71°C
refractive index 
32 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
Methanol (Slightly), Water (Slightly, Sonicated)
form 
Powder or Crystalline Powder
color 
White
optical activity
[α]/D 33.0±2.0°, c = 1 in H2O
Sensitive 
Hygroscopic
BRN 
4714125
CAS DataBase Reference
65365-28-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38-36/37/38
Safety Statements 
26-36-28
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
689491
Product name
D-Proline methyl ester hydrochloride
Purity
≥98.0% (AT)
Packaging
5g
Price
$124
Updated
2025/07/31
Sigma-Aldrich
Product number
689491
Product name
D-Proline methyl ester hydrochloride
Purity
≥98.0% (AT)
Packaging
1g
Price
$30
Updated
2023/06/20
TCI Chemical
Product number
P1730
Product name
D-Proline Methyl Ester Hydrochloride
Purity
>96.0%(N)(T)
Packaging
1g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
P1730
Product name
D-Proline Methyl Ester Hydrochloride
Purity
>96.0%(N)(T)
Packaging
5g
Price
$81
Updated
2025/07/31
TRC
Product number
P755950
Product name
D-Proline methyl ester hydrochloride
Packaging
10g
Price
$145
Updated
2021/12/16
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Methyl pyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

D-Proline Methyl Ester is a methyl ester of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

609-36-9

2133-40-6

The general steps for the synthesis of L-proline methyl ester hydrochloride from methanol and DL-proline are as follows: Step 1: Synthesis of methylpyrrolidine-2-carboxylic acid hydrochloride Thionyl chloride (15.7 mL, 217.4 mmol) was slowly added dropwise to a mixed solution of DL-proline (5.0 g, 43.47 mmol) and methanol (50 mL) at about 0 °C, and the dropwise process lasted for about 15 minutes. The reaction mixture was stirred at room temperature for about 16 hours before the solvent was removed by vacuum concentration. The resulting gel was ground with n-pentane, decanted and dried to give D-proline methyl ester hydrochloride as an off-white solid (6.25 g, 87% yield). The product characterization data were as follows: 1H NMR (400 MHz, DMSO-d6) δ 1.87-2.04 (m, 3H), 2.21-2.28 (m, 1H), 3.22-3.26 (m, 2H), 3.75 (s, 3H), 4.34 (t, J = 7.8 Hz, 1H). IR (film) υ 3513, 3130, 2597, 1740, 1632, 1452, 1402, 1245, 1178, 1046, 764 cm-1; MS 130 (M + 1).

References

[1] Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 584 - 596
[2] Patent: US2010/105755, 2010, A1. Location in patent: Page/Page column 11-12
[3] Molecules, 2008, vol. 13, # 5, p. 1111 - 1119
[4] Journal of Organic Chemistry, 1991, vol. 56, # 8, p. 2775 - 2781
[5] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 91; 93

Methyl pyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl pyrrolidine-2-carboxylate hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
D-Pro-ome.HCl 65365-28-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-28
Sichuan Jiaying Lai Technology Co.,LTD
Product
D-Pro-ome.HCl 65365-28-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-23
Career Henan Chemical Co
Product
Methyl pyrrolidine-2-carboxylate hydrochloride 65365-28-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 377
Release date
2019-09-01

65365-28-8, Methyl pyrrolidine-2-carboxylate hydrochlorideRelated Search:

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  • C6H11NO2HCl
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  • Amino Acids and Derivatives
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  • Amino Acids (C-Protected)
  • Biochemistry
  • Amino hydrochloride
  • Amino Acid Derivatives
  • Peptide Synthesis
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