Methyl pyrrolidine-2-carboxylate hydrochloride
- Product Name
- Methyl pyrrolidine-2-carboxylate hydrochloride
- CAS No.
- 65365-28-8
- Chemical Name
- Methyl pyrrolidine-2-carboxylate hydrochloride
- Synonyms
- D-PRO-OME;H-D-Pro-OMe;96.0%(N&D-Pro-Ome.Hcl;H-D-PRO-OME HCL;D-PROLINE-OME HCL;Methyl pyrrolidine-2;H-D-Pro-OMe·HCl (Solid);D-PROLINE METHYL ESTER HCL;METHYL D-PROLINATE HYDROCHLORIDE
- CBNumber
- CB5675050
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 65365-28-8.mol
Methyl pyrrolidine-2-carboxylate hydrochloride Property
- Melting point:
- 69-71°C
- refractive index
- 32 ° (C=1, H2O)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly, Sonicated)
- form
- Powder or Crystalline Powder
- color
- White
- optical activity
- [α]/D 33.0±2.0°, c = 1 in H2O
- Sensitive
- Hygroscopic
- BRN
- 4714125
- CAS DataBase Reference
- 65365-28-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-36/37/38
- Safety Statements
- 26-36-28
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 689491
- Product name
- D-Proline methyl ester hydrochloride
- Purity
- ≥98.0% (AT)
- Packaging
- 5g
- Price
- $124
- Updated
- 2025/07/31
- Product number
- 689491
- Product name
- D-Proline methyl ester hydrochloride
- Purity
- ≥98.0% (AT)
- Packaging
- 1g
- Price
- $30
- Updated
- 2023/06/20
- Product number
- P1730
- Product name
- D-Proline Methyl Ester Hydrochloride
- Purity
- >96.0%(N)(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- P1730
- Product name
- D-Proline Methyl Ester Hydrochloride
- Purity
- >96.0%(N)(T)
- Packaging
- 5g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- P755950
- Product name
- D-Proline methyl ester hydrochloride
- Packaging
- 10g
- Price
- $145
- Updated
- 2021/12/16
Methyl pyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
D-Proline Methyl Ester is a methyl ester of D-Proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
609-36-9
2133-40-6
The general steps for the synthesis of L-proline methyl ester hydrochloride from methanol and DL-proline are as follows: Step 1: Synthesis of methylpyrrolidine-2-carboxylic acid hydrochloride Thionyl chloride (15.7 mL, 217.4 mmol) was slowly added dropwise to a mixed solution of DL-proline (5.0 g, 43.47 mmol) and methanol (50 mL) at about 0 °C, and the dropwise process lasted for about 15 minutes. The reaction mixture was stirred at room temperature for about 16 hours before the solvent was removed by vacuum concentration. The resulting gel was ground with n-pentane, decanted and dried to give D-proline methyl ester hydrochloride as an off-white solid (6.25 g, 87% yield). The product characterization data were as follows: 1H NMR (400 MHz, DMSO-d6) δ 1.87-2.04 (m, 3H), 2.21-2.28 (m, 1H), 3.22-3.26 (m, 2H), 3.75 (s, 3H), 4.34 (t, J = 7.8 Hz, 1H). IR (film) υ 3513, 3130, 2597, 1740, 1632, 1452, 1402, 1245, 1178, 1046, 764 cm-1; MS 130 (M + 1).
References
[1] Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 584 - 596
[2] Patent: US2010/105755, 2010, A1. Location in patent: Page/Page column 11-12
[3] Molecules, 2008, vol. 13, # 5, p. 1111 - 1119
[4] Journal of Organic Chemistry, 1991, vol. 56, # 8, p. 2775 - 2781
[5] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 91; 93
Methyl pyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl pyrrolidine-2-carboxylate hydrochloride Suppliers
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View Lastest Price from Methyl pyrrolidine-2-carboxylate hydrochloride manufacturers
- Product
- D-Pro-ome.HCl 65365-28-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-28
- Product
- D-Pro-ome.HCl 65365-28-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-23
- Product
- Methyl pyrrolidine-2-carboxylate hydrochloride 65365-28-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 377
- Release date
- 2019-09-01