Description References
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Azamethiphos

Description References
Product Name
Azamethiphos
CAS No.
35575-96-3
Chemical Name
Azamethiphos
Synonyms
PHOSPHOROTHIOATE;azametifos;Azametiphos;AZAMETHIFOS;snip;SNIP(R);GS 40616;ALFACRON;SNIP(TM);cga18809
CBNumber
CB5687123
Molecular Formula
C9H10ClN2O5PS
Formula Weight
324.68
MOL File
35575-96-3.mol
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Azamethiphos Property

Melting point:
88-93°C
Boiling point:
428.8±55.0 °C(Predicted)
Density 
1.566±0.06 g/cm3(Predicted)
vapor pressure 
4.9 x 10-6 Pa (20 °C)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
Water Solubility 
1100 mg l-1 (20 °C)
pka
0.94±0.20(Predicted)
color 
White to off-white
CAS DataBase Reference
35575-96-3(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorothioic acid, s-[(6-chloro-2-oxooxazolo[4,5-b]pyridin-3(2h)-yl)methyl] o,o-dimethyl ester(35575-96-3)
EPA Substance Registry System
Azamethiphos (35575-96-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36-40-21-67-36/37/38
Safety Statements 
26-36/37-24/25-23
RIDADR 
UN 1593 6.1/PG 3
WGK Germany 
3
RTECS 
TE8070000
HS Code 
29349990
Toxicity
LD50 orl-rat: 1180 mg/kg PEMNDP 9,44,91
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H331Toxic if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45331
Product name
Azamethiphos
Purity
PESTANAL
Packaging
250mg
Price
$67.3
Updated
2024/03/01
Alfa Aesar
Product number
H66105
Product name
S-[(6-Chloro-2-oxooxazolo[4,5-b]pyridin-3yl)methyl] O,O-dimethyl phosphorothioate, 95%
Packaging
1g
Price
$81.3
Updated
2023/06/20
Alfa Aesar
Product number
H66105
Product name
S-[(6-Chloro-2-oxooxazolo[4,5-b]pyridin-3yl)methyl] O,O-dimethyl phosphorothioate, 95%
Packaging
5g
Price
$332
Updated
2021/12/16
Alfa Aesar
Product number
H66105
Product name
S-[(6-Chloro-2-oxooxazolo[4,5-b]pyridin-3yl)methyl] O,O-dimethyl phosphorothioate, 95%
Packaging
250mg
Price
$27.1
Updated
2023/06/20
TRC
Product number
A801300
Product name
Azamethiphos
Packaging
5g
Price
$80
Updated
2021/12/16
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Azamethiphos Chemical Properties,Usage,Production

Description

Azamethiphos is an organothiophosphate insecticide. It can be used as a veterinary drug used in the salmon fish farming for controlling parasites such as salmon lice (Lepeophtheirus salmonis), a marine ectoparasitic copepod on salmonid species. Its primary target is on the acetylcholinesterase, a serine hydrolase involved in neurotransmission at cholinergic synapses and neuromuscular junctions.

References

Intorre, L, et al. "Safety of azamethiphos in eel, seabass and trout." Pharmacological Research the Official Journal of the Italian Pharmacological Society 49.2(2004):171. Kaur, K, et al. "Mechanism behind Resistance against the Organophosphate Azamethiphos in Salmon Lice (Lepeophtheirus salmonis). " Plos One 10.4(2015):e0124220.

Chemical Properties

white to light yellow crystal powde

Uses

Azamethiphos is used to control flies and other insect pests in animal houses and also public hygiene and health pests such as mosquitoes and cockroaches. It has recently been used to control sea lice in salmon.

Uses

Synergistic insecticidal and acaricidal organophosphorus compound

Definition

ChEBI: Azamethiphos is an organic thiophosphate, an organothiophosphate insecticide, an organochlorine insecticide and an organochlorine acaricide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to an oxazolo[4,5-b]pyridin-2(3H)-one.

Safety Profile

Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, SOx, POx, and Cl- .

Metabolic pathway

Azamethiphos is metabolised in mammals via hydrolysis, followed by opening of the oxazolinone ring and conjugation of the resultant aminopyridinol as the glucuronide and sulfate ester.

Metabolism

Azamethiphos is metabolized via the cleavage of phosphorothiolate C?S bond, followed by N-demethylation and opening of the oxazolinone ring and conjugation of the resultant aminochloropyridinol as the glucuronide and sulfate ester.

Toxicity evaluation

Acute oral LD50 for rats is 1180 mg/kg. Inhalation LC50 (4 h) for rats is >560 mg/m3 air. ADI is 0.025 mg/kg.

Degradation

Azamethiphos is unstable in alkalis and acids. The DT50 values at pH 5,7 and 9 were 800,260 and 4.3 hours, respectively (PM).

Azamethiphos Preparation Products And Raw materials

Raw materials

Sulfur Thio ammonium salt formaldehyde Chlorine Dimethyl sulfide Oxazole Dimethyl phosphite

Preparation Products

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Azamethiphos Suppliers

Australia 1 Canada 2 China 245 Europe 2 France 2 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 7 United States 24 Global 289
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from Azamethiphos manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Azamethiphos 35575-96-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24
Hebei Chuanghai Biotechnology Co,.LTD
Product
Azamethiphos 35575-96-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-12
Hebei Mojin Biotechnology Co.,Ltd
Product
Azamethiphos 35575-96-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-21

35575-96-3, AzamethiphosRelated Search:

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