3-Amino-1,2-propanediol

ChemicalBook > CAS DataBase List > 3-Amino-1,2-propanediol

3-Amino-1,2-propanediol

Product Name: 3-Amino-1,2-propanediol
CAS No.: 616-30-8
Chemical Name: 3-Amino-1,2-propanediol
Synonyms: 3-AMINOPROPANE-1,2-DIOL;APD;3-AMINO-1,2-PROPANDIOL;Isoserinol;AMINOPROPANEDIOL;3--1,2-;1-AMINOGLYCEROL;1-aminopropanediol;3-Amino-1,2-propaned;Glycerol α-monoamine
CBNumber: CB5701843
Molecular Formula: C3H9NO2
Formula Weight: 91.11
MOL File: 616-30-8.mol

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3-Amino-1,2-propanediol Property

Melting point:: 55-57 °C
Boiling point:: 264-265 °C739 mm Hg(lit.)
Density: 1.175 g/mL at 25 °C(lit.)
vapor pressure: <1 hPa (20 °C)
refractive index: n20/D 1.492(lit.)
Flash point:: >230 °F
storage temp.: Store below +30°C.
solubility: >1000g/l soluble
form: liquid (highly viscous)
pka: 12.11±0.35(Predicted)
color: Clear colorless to pale yellow
Specific Gravity: 1.175
PH: 11 (100g/l, H2O, 20℃)
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 1719121
InChIKey: KQIGMPWTAHJUMN-UHFFFAOYSA-N
LogP: -2.079 (est)
CAS DataBase Reference: 616-30-8(CAS DataBase Reference)
NIST Chemistry Reference: 3-Amino-1,2-propanediol(616-30-8)
EPA Substance Registry System: 1,2-Propanediol, 3-amino- (616-30-8)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 26-36/37/39-45-36
RIDADR: UN 2735 8/PG 2
WGK Germany: 2
RTECS: TY2800000
F: 10-21
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29221980
Toxicity: LD50 orally in Rabbit: 7500 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A76001
Product name: (±)-3-Amino-1,2-propanediol
Purity: 97%
Packaging: 5g
Price: $52.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: A76001
Product name: (±)-3-Amino-1,2-propanediol
Purity: 97%
Packaging: 25g
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18522
Product name: 3-Amino-1,2-propanediol
Purity: for synthesis
Packaging: 25mL
Price: $92.1
Updated: 2024/03/01

TCI Chemical

Product number: A0628
Product name: 3-Amino-1,2-propanediol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $58
Updated: 2024/03/01

Alfa Aesar

Product number: B22672
Product name: (±)-3-Amino-1,2-propanediol, 97%
Packaging: 25g
Price: $57.65
Updated: 2024/03/01

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3-Amino-1,2-propanediol Chemical Properties,Usage,Production

Description

3-Amino-1,2-propanediol (APD) is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity.

Chemical Properties

3-Amino-1,2-propanediol is a very viscous transparent colorless to pale yellow liquid with a melting point of 55-57 °C and a boiling point of 264-265 °C. The density at 25 °C is 1.175 g/mL. soluble in water.

Originator

Henkel (W. Germany)

Uses

3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials.

Application

3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. It is also used in the synthesis of Decarbazolyl Carvedilol (D212720), a metabolite of Carvedilol (C184625) found in humans, rats, dogs and mice.

Preparation

3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

Application

3-Amino-1,2-propanediol is used as a chiral selector ligand, used subsequently for a nucleophilic substitution with the dimethoxytrityl (DMT)-protected.

brand name

Aminomux

General Description

3-Amino-1,2-propanediol is a chiral glycerol derivative. It could used as a hydrogen bond donor in the design of a new deep eutectic solvent which have emerged as a suitable alternative to VOCs (volatile organic compounds) for diverse practical applications including, among others, drug delivery, electrochemistry, material design, extractions and, of course, organic reactions, alone or together twith other sustainable reaction-media[1]. It can also used as a core present in antiviral compounds to skeleton to design a novel class of anti-adenovirus agents[2].

Hazard

3-Amino-1,2-propanediol is Danger.
H314 (93.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 (56.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.

storage

3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers.

References

[1] Antenucci A, et al. Design of a New Chiral Deep Eutectic Solvent Based on 3-Amino-1,2-propanediol and Its Application in Organolithium Chemistry. Molecules, 2022; 27.
[2] Mazzotta S, et al. Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol. Bioorganic Chemistry, 2021; 114: 105095.

3-Amino-1,2-propanediol Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium hydroxide Methanol 3-Chloro-1,2-propanediol Epichlorohydrin

Preparation Products

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View Lastest Price from 3-Amino-1,2-propanediol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: 3-Amino-1,2-propanediol 616-30-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-18

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 3-Amino-1,2-propanediol 616-30-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.6%
Supply Ability: 100000
Release date: 2024-04-25

Henan Fengda Chemical Co., Ltd

Product: 3-Amino-1,2-Propanediol 616-30-8
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

616-30-8, 3-Amino-1,2-propanediolRelated Search:

(R)-(-)-1,2-Propanediol 1-Methoxy-2-propyl acetate Propylene glycol 1,3-Propanediol Glycine ALTRENOGEST 3-Aminophenol 1-Phenoxy-2-propanol DI(PROPYLENE GLYCOL) BUTYL ETHER 1-Methoxy-2-propanol 6-Aminocaproic acid 2-METHYL-1,3-PROPANEDIOL 3-Amino-1-propanesulfonic acid 3-Amino-1-hydroxyadamantane Tris(hydroxymethyl)aminomethane 2-AMINOPROPANE-1,3-DIOL,2-AMINO-1,3-PROPANEDIOL [1S,2S,(+)]-1-Phenyl-2-amino-1,3-propanediol 2-AMINO-1,3-PROPANEDIOL HYDROCHLORIDE,2-Amino-1,3-propanediol hydrochloride, 2-Amino-1,3-propanediol

3-Aminopropane-1,2-diol 99%

3-AMINO-1,2-PROPANEDIOL 98%

Aminopropylene glycol

1-Amino-2,3-dihydroxypropane

Isoserinol

Glycerol α-monoamine

3-Amino-1,2-propanediol,98%

3-Amino-1,2-propanediol (Isoserinol)

3-Amino-1,2-propaned

3-AMNIO-1,2-PROPANEDIOL

3-AMino-1,2-propanediol, 98% 100GR

3-AMino-1,2-propanediol, 98% 25GR

3-AMINO-1,2-PROPANEDIOL FOR SYNTHESIS

3 - aMino - 1, 2 - propylene glycol

3-AMINO-1,2-DIHYDROXYPROPANE

3-AMINO-1,2-PROPANDIOL

(+/-)-3-AMINO-1,2-PROPANEDIOL

3-AMINO-1,2-PROPANEDIOL

3-AMINOPROPANE-1,2-DIOL

2,3-DIHYDROXY-1-PROPYLAMINE

1-AMINO-2,3-PROPANDIOL

1-AMINO-2,3-PROPANEDIOL

1-AMINOGLYCEROL

1,2-DIHYDROXY-3-AMINOPROPANE

1,2-DIHYDROXY-1-PROPYLAMINE

1,2-Propanediol, 3-amino-

1-aminopropanediol

2,3-Dihydroxypropylamine

2,3-Propandiol-1-amine

3-amino-2-propanediol

APD

(+/-)-3-AMINO-1,2-PROPANEEDIOL

3-AMINO-1,2-PROOPANEDIOL

3-Amino-1,2-propanediol USP/EP/BP

AMINOPROPANEDIOL

(+/-)-3-AMINO-1,2-PROPANEDIOL

3-amino-1,2-propanediol (APD)

1-Aminopropan-2,3-diol

Ethyl Acetate Impurity 32

3--1,2-

616-30-8

NH2CH2CHOHCH2OH

AMINE

Oxygen Compounds

Organic Building Blocks

Amino Alcohols

Building Blocks

API

Alcohols and Derivatives

Amino Alcohols

Organic Building Blocks

Oxygen Compounds

616-30-8