H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

Product Name: H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
CAS No.: 143413-47-2
Chemical Name: H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Synonyms: (ARG)9;RRRRRRRRR;Peptide R9;R 9 peptide;Nonaarginine;(Arg)9 peptide;H-RRRRRRRRR-NH2;Poly Arginine 9;Nona-L-arginine;R9/Nonaarginine
CBNumber: CB5706464
Molecular Formula: C54H110N36O10
Formula Weight: 1423.69
MOL File: 143413-47-2.mol

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H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Property

Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
Sequence: H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Aaron Chemicals

Product number: AR009BQF
Product name: H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Purity: 97%
Packaging: 100mg
Price: $220
Updated: 2021/12/16

Aaron Chemicals

Product number: AR009BQF
Product name: H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Purity: 97%
Packaging: 250mg
Price: $326
Updated: 2021/12/16

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H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemical Properties,Usage,Production

Uses

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].

Biological Activity

(Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.

in vitro

Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC ₅₀ =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC ₅₀ =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC ₅₀ =6 μM).

in vivo

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .

target

IC50: 0.78 μM (neuroprotection)

References

[1] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200
[2] Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81. DOI:10.1007/s10571-013-9999-3
[3] Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004. DOI:10.1038/jcbfm.2015.11

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Suppliers

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View Lastest Price from H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH manufacturers

Career Henan Chemical Co

Product: H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH 143413-47-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

143413-47-2, H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OHRelated Search:

GO-203 TAT (48 - 57) K9 D-R9 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE LCKLSL HUWENTOXIN IV CALCIUM-LIKE PEPTIDE DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS COG-1410 HNGF6A PHRIXOTOXIN 3 GIP (1-39) H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH (ARG)9, TAMRA-LABELED (ARG)9, FAM-LABELED H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH H-ARG-ARG-ARG-ARG-OH

H-RRRRRRRRR-NH2

RRRRRRRRR

(ARG)9

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

Nonaarginine

H(-Arg)9-OH, Nonaarginine

(Arg)9 peptide

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Poly Arginine 9|(Arg)9 peptide|RRRRRRRRR

Poly Arginine 9|(Arg)9 NJ-Peptide

Poly Arginine 9

L-Arginine,L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-

Nona-L-arginine

Peptide R9

L-Arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginine

R 9 peptide

(6S,9S,12S,15S,18S,21S,24S,27S,30S)-1,6-Diamino-9,12,15,18,21,24,27,30-octakis(3-guanidinopropyl)-1-imino-7,10,13,16,19,22,25,28-octaoxo-2,8,11,14,17,20,23,26,29-nonaazahentriacontan-31-oic acid

R9/Nonaarginine

143413-47-2

C54H110N36O10

peptide