ChemicalBook > CAS DataBase List > 2,4-DICHLORO-3-NITRO-QUINOLINE

2,4-DICHLORO-3-NITRO-QUINOLINE

Uses

Product Name: 2,4-DICHLORO-3-NITRO-QUINOLINE
CAS No.: 132521-66-5
Chemical Name: 2,4-DICHLORO-3-NITRO-QUINOLINE
Synonyms: Zinc02551827;AURORA KA-4144;2,4-Dichlor-3-nitro-chinolin;3-NITRO-2,4-DICHLORO QUINOLINE;2,4-DICHLORO-3-NITRO-QUINOLINE;Quinoline, 2,4-dichloro-3-nitro-;2,4-Dichloro-3-nitroquinoline 95%;Benzaldehyde,4-methoxy-4-(phenylmethoxy)-;2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH
CBNumber: CB5773772
Molecular Formula: C9H4Cl2N2O2
Formula Weight: 243.05
MOL File: 132521-66-5.mol

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2,4-DICHLORO-3-NITRO-QUINOLINE Property

Melting point:: 102 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
Boiling point:: 359.7±37.0 °C(Predicted)
Density: 1.593±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: -4.98±0.50(Predicted)
color: White to Off-White
InChI: InChI=1S/C9H4Cl2N2O2/c10-7-5-3-1-2-4-6(5)12-9(11)8(7)13(14)15/h1-4H
InChIKey: RSFJVCHKGRUCIC-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(Cl)=C([N+]([O-])=O)C=1Cl

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D439308
Product name: 2,4-Dichloro-3-nitroquinoline
Packaging: 50mg
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-5-2U
Product name: 2,4-Dichloro-3-nitroquinoline
Packaging: 250mg
Price: $376
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-5-2U
Product name: 2,4-Dichloro-3-nitroquinoline
Packaging: 1g
Price: $824
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142593
Product name: 2,4-DICHLORO-3-NITRO-QUINOLINE
Purity: 97.00%
Packaging: 1G
Price: $1022.18
Updated: 2021/12/16

Matrix Scientific

Product number: 128520
Product name: 2,4-Dichloro-3-nitroquinoline
Purity: 97%
Packaging: 1g
Price: $495
Updated: 2021/12/16

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2,4-DICHLORO-3-NITRO-QUINOLINE Chemical Properties,Usage,Production

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Uses

2,4-Dichloro-3-nitroquinoline has antitumor activity.

Synthesis

15151-57-2

132521-66-5

(2) Synthesis of 2,4-dichloro-3-nitroquinoline: In a 20 mL round-bottomed flask, 3-nitroquinoline-2,4-diol (1 g, 4.85 mmol), phosphorus trichloride (appropriate amount) and N,N-dimethylaniline (0.19 mL) were added sequentially. The reaction mixture was stirred at 90 °C for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water, and stirring was continued for 0.5 hours. The precipitate precipitated was collected by filtration and dried under vacuum overnight. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1, v/v) to give 0.7 g of white solid product in 59.4% yield.

References

[1] Medicinal Chemistry Research, 2014, vol. 23, # 6, p. 2964 - 2975
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4450 - 4465
[3] Patent: WO2013/67597, 2013, A1. Location in patent: Page/Page column 78
[4] Patent: WO2018/191746, 2018, A1. Location in patent: Paragraph 0391
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 921 - 926

2,4-DICHLORO-3-NITRO-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-3-NITRO-QUINOLINE Suppliers

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View Lastest Price from 2,4-DICHLORO-3-NITRO-QUINOLINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-21

Career Henan Chemical Co

Product: 2,4-DICHLORO-3-NITRO-QUINOLINE 132521-66-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 200KG
Release date: 2018-08-15

132521-66-5, 2,4-DICHLORO-3-NITRO-QUINOLINERelated Search:

2,4-DIBROMO-3-CHLOROPYRIDINE 7-Benzyl-2,4-dichloro-5,6... 2,4-Dibromothiazole-5-methanol 2,4-DIBROMO-5-NITROPYRIDINE 2,4-dichloro-6-phenylpyrimidine 2,4-dichloro-5-iodo-6-methylpyrimidine CHEMPACIFIC 38112 2,4-DIBROMOBENZOTHIAZOLE 5-Thiazolecarboxylic acid, 2,4-dibromo- 4-Chloro-3-nitropyridine hydrochloride 4-Chloro-3-nitropyridine 3-Amino-4-chloropyridine 4-Chloro-3-nitroquinoline 2,4-Dichloro-3-nitropyridine Ethyl 5-Bromoindole-2-carboxylate 2,4-DICHLORO-3-NITRO-QUINOLINE 2,4-DICHLORO-3-AMINOPYRIDINE 2-CHLORO-3-NITROQUINOLINE

AURORA KA-4144

2,4-DICHLORO-3-NITRO-QUINOLINE

3-NITRO-2,4-DICHLORO QUINOLINE

2,4-Dichlor-3-nitro-chinolin

Zinc02551827

2,4-Dichloro-3-nitroquinoline 95%

Quinoline, 2,4-dichloro-3-nitro-

2,4-DICHLORO-3-NITRO-QUINOLINE ISO 9001：2015 REACH

Benzaldehyde,4-methoxy-4-(phenylmethoxy)-

132521-66-5