3-Amino-1-adamantanol
- Product Name
- 3-Amino-1-adamantanol
- CAS No.
- 702-82-9
- Chemical Name
- 3-Amino-1-adamantanol
- Synonyms
- 3-AMINO-1-ADAMANTANOL;3-AMINOADAMANTAN-1-OL;3-Amino-1-admantanol;4-aminoadamantan-1-ol;3-Amino-1-Adamantanamine;3-Hydroxy-1-aminoadamantane;1-AMINO-3-HYDROXYADAMANTANE;C1oH17NO;AKOS BB-9784;CHEMBRDG-BB 4003530
- CBNumber
- CB5777891
- Molecular Formula
- C10H17NO
- Formula Weight
- 167.25
- MOL File
- 702-82-9.mol
3-Amino-1-adamantanol Property
- Melting point:
- 265 °C (dec.)(lit.)
- Boiling point:
- 266.8±23.0 °C(Predicted)
- Density
- 1.252±0.06 g/cm3(Predicted)
- Flash point:
- 230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 15.07±0.40(Predicted)
- color
- White to yellow
- Water Solubility
- Soluble in organic solvents,insoluble in water.
- InChI
- InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9/h7-8,12H,1-6,11H2
- InChIKey
- DWPIPTNBOVJYAD-UHFFFAOYSA-N
- SMILES
- C12(O)CC3CC(CC(N)(C3)C1)C2
- CAS DataBase Reference
- 702-82-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 523690
- Product name
- 3-Amino-1-adamantanol
- Purity
- 96%
- Packaging
- 1g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 523690
- Product name
- 3-Amino-1-adamantanol
- Purity
- 96%
- Packaging
- 5g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- A2079
- Product name
- 3-Amino-1-adamantanol Hydrate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- A2079
- Product name
- 3-Amino-1-adamantanol Hydrate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- H64137
- Product name
- 3-Amino-1-adamantanol, 98+%
- Packaging
- 5g
- Price
- $48.65
- Updated
- 2024/03/01
3-Amino-1-adamantanol Chemical Properties,Usage,Production
Description
3-Amino-1-adamantanol is an important adamantane drug intermediate mainly used in the synthesis of inhibitors with antihyperglycaemic properties for the preparation of Vildagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor used in the treatment of type 2 diabetes.
Chemical Properties
White solid
Uses
It is employed in the synthesis of inhibitors with antihyperglycemic properties. vil- dagliptin is synthesised from 3-Amino-1-adamantanol.
Uses
3-Amino-1-hydroxyadamantane can be employed in the synthesis of inhibitors with antihyperglycemic properties.
Uses
As reagent, 3-Amino-1-hydroxyadamantane can be used in the preparation of Vildagliptin.
Synthesis
A preparation method of 3-amino-1-adamantanol comprises the following steps: (1) adding amantadine or a salt thereof to sulfuric acid at 10-30 DEG C and adding a mixed acid dropwise to perform a nitration reaction to obtain a reaction liquid; (2) adding the reaction liquid to water and mixing the reaction liquid with water to obtain a mixed solution; (3) performing a hydroxylation reaction under the effect of alkaline to obtain the 3-amino-1-adamantanol. The preparation method employs the raw material, is easy to obtain, is simple in operations, is environmentally protective, is low in cost, and is high in yield, which is generally higher than 80%, maximally 90.1%.
3-Amino-1-adamantanol Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-1-adamantanol Suppliers
- Tel
- --
- Fax
- --
- Country
- Czech Republic
- ProdList
- 10
- Advantage
- 58
- Tel
- --
- Fax
- --
- vi@vuos.com
- Country
- Czech Republic
- ProdList
- 64
- Advantage
- 58
- Tel
- --
- Fax
- --
- lach-ner@lach-ner.cz
- Country
- Czech Republic
- ProdList
- 446
- Advantage
- 59
View Lastest Price from 3-Amino-1-adamantanol manufacturers
- Product
- 3-Amino-1-adamantanol 702-82-9
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-17
- Product
- 3-Amino-1-hydroxyadamantane 702-82-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-02
- Product
- 3-Amino-1-adamantanol 702-82-9
- Price
- US $99.00-66.00/kg
- Min. Order
- 0.0010000000474974513kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-19