CALCINEURIN

Product Name
CALCINEURIN
CAS No.
90371-51-0
Chemical Name
CALCINEURIN
Synonyms
CAN;PP2B;PPASE-2B;CALCINEURIN;CALCINEURIN/PP2B;CALCINEURIN, HUMAN;PROTEIN PHOSPHATASE 2B;Calcineurin bovine brain;MODULATOR BINDING PROTEIN;CALMODULIN BINDING PROTEIN
CBNumber
CB5781726
Formula Weight
0
MOL File
Mol file
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CALCINEURIN Property

storage temp. 
−20°C
solubility 
H2O: soluble
form 
lyophilized powder
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1907
Product name
Calcineurin from bovine brain
Purity
lyophilizedpowder,≥2,500?units/mgprotein
Packaging
100units
Price
$740
Updated
2024/03/01
Usbiological
Product number
151626
Product name
Calcineurin
Packaging
200ul
Price
$436
Updated
2021/12/16
Usbiological
Product number
405761
Product name
Calcineurin
Packaging
1Kit
Price
$479
Updated
2021/12/16
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CALCINEURIN Chemical Properties,Usage,Production

Uses

Calcineurin from bovine brain has been used:

  • as a positive control in western blot analysis of oocytes and cumulus cells proteome
  • as a positive control in calmodulin (CaM)-agarose binding assay
  • to test its phosphatase activity in the presence of okadaic acid

General Description

Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.

Biochem/physiol Actions

Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.

CALCINEURIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CALCINEURIN Suppliers

China 4 Germany 1 Japan 2 Switzerland 2 United Kingdom 1 United States 6 Global 16
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80

90371-51-0, CALCINEURINRelated Search:

TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE METHYL ISOCYANOACETATE Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE PHENYLSELENOL Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate Benzyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE SALCOMINE N-BUTYLISOCYANIDE Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) CALCINEURIN,CALCINEURIN, HUMAN,CALCINEURIN/PP2B

  • Calcineurin bovine brain
  • CALCINEURIN FROM BOVINE BRAIN, >10 U/MG
  • calcium/calmodulin-activated protein phosphatase
  • MODULATOR BINDING PROTEIN
  • PP2B
  • PPASE-2B
  • PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI
  • PROTEIN PHOSPHATASE 2B
  • CAN
  • CALMODULIN BINDING PROTEIN
  • CALCINEURIN
  • CALCINEURIN, HUMAN
  • CALCINEURIN/PP2B
  • 90371-51-0