ChemicalBook > CAS DataBase List > (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID

Product Name: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
CAS No.: 13570-08-6
Chemical Name: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
Synonyms: NSC 525202;AKOS BBS-00002502;RARECHEM AK ML 0141;IFLAB-BB F1727-0259;CHEMBRDG-BB 4400292;2-BENZIMIDAZOLEACETIC ACID;Benzimidazole-2-acetic acid;2-Benzimidazolylacetic acid;1H-Benzimidazole-2-acetic acid;2-(Carboxymethyl)benzimidazole
CBNumber: CB5838729
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 13570-08-6.mol

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(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Property

Melting point:: 116 °C
Boiling point:: 498.3±28.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.54±0.30(Predicted)
Appearance: Light yellow to light brown Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B130015
Product name: (1H-Benzoimidazol-2-yl)aceticAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: X9925
Product name: (1H-benzoimidazol-2-yl)aceticacid
Packaging: 1g
Price: $47
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50783
Product name: (1H-Benzoimidazol-2-Yl)-Acetic Acid
Packaging: 50mg
Price: $60.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50783
Product name: (1H-Benzoimidazol-2-Yl)-Acetic Acid
Packaging: 100mg
Price: $97
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50783
Product name: (1H-Benzoimidazol-2-Yl)-Acetic Acid
Packaging: 250mg
Price: $122.5
Updated: 2021/12/16

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(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Chemical Properties,Usage,Production

Uses

(1h-Benzoimidazol-2-yl)-acetic Acid is a useful intermediate for the synthesis of benzisothiazole/benzimidazole derivatives with acidic groups that exhibits numerous pharmacological properties.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 36, p. 1746, 1993 DOI: 10.1021/jm00064a008

Synthesis

4414-88-4

13570-08-6

General procedure for the synthesis of benzimidazole-2-acetic acid from 2-cyanomethylbenzimidazole: A mixture of 1 g of 2-cyanomethylbenzimidazole (3a-b) with 2 ml of 37% aqueous hydrochloric acid in the presence of 1 ml of benzenesulphonic acid was heated and stirred under reflux conditions for 4-5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ether (3 x 30 ml), followed by removal of solvent by distillation under reduced pressure to afford the target products benzimidazole-2-acetic acid (4a-b). 4.3.1. 1H-benzimidazole-2-acetic acid (4a, C9H8N2O2) was a green solid, hygroscopic, with a yield of 81% and a melting point of 240-242 °C; TLC Rf value of 0.42 [unfolding reagent ratio of toluene: ethyl acetate: formic acid (5:4:1)]; IR spectra (KBr, cm^-1 ): 3624 (O-H telescoping vibration) 3230 (N-H stretching vibration), 1722 (C=O stretching vibration); 1H NMR (300MHz, DMSO-d6) δ (ppm): 3.64 (single peak, 2H, CH2COOH), 7.58 (double peaks, 2H, J=7.5,0.9Hz, H-5,6 on benzimidazole ring), 7.92 (double peaks, 2H, J=7.5 Hz, H-4,7 on the benzimidazole ring), 10.59 (broad peak, 1H, COOH), 12.03 (broad peak, 1H, NH).13C NMR (75 MHz, DMSO-d6) δ (ppm): 164.20, 152.20, 131.95, 128.32, 122.50, 48.40. Calculated values for elemental analysis (%) : C, 61.36; H, 4.58; N, 15.90; measured values (%): C, 61.33; H, 4.56; N, 15.92.

References

[1] Patent: US5792768, 1998, A
[2] Farmaco, 2002, vol. 57, # 5, p. 363 - 367
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 12, p. 1746 - 1753
[5] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 243

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (1H-benzoimidazol-2-yl)acetic acid 13570-08-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Honest Joy Holdings Limited

Product: 1H-benzoimidazol-2-yl)acetic acid 13570-08-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.2%
Supply Ability: 100 tons
Release date: 2022-01-25

Career Henan Chemical Co

Product: (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID 13570-08-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

13570-08-6, (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACIDRelated Search:

BENZOFURAN-3-BORONIC ACID Benzomorpholine METHYL BENZO[B]THIOPHENE-2-CARBOXYLATE 2-(Benzofuran-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione, 2-Benzofuranboronic acid MIDA ester Benzimidazole-5,6-dicarboxylic acid 2-Aminobenzo[b]thiophene 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole Benzothiazole-2-acetonitrile 6-BENZOFURANAMINE 4-BENZOFURANCARBOXYLICACIDMETHYLESTER 2-CYANOBENZOFURAN 1-benzofuran-3-carboxylic acid (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID ETHYL ESTER Coumarin 30 2-CHLORO-5-METHOXYBENZIMIDAZOLE 2-BENZIMIDAZOLEPROPIONIC ACID DISPERSE YELLOW 82 (2-METHYL-BENZOIMIDAZOL-1-YL)ACETIC ACID

CHEMBRDG-BB 4400292

IFLAB-BB F1727-0259

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID

1H-BENZIMIDAZOL-2-YLACETIC ACID

AKOS BBS-00002502

RARECHEM AK ML 0141

1H-Benzimidazole-2-aceticacid(9CI)

1H-Benzimidazole-2-acetic acid

1H-benzimidazol-2-ylacetic acid(SALTDATA: FREE)

2-(1H-benzo[d]imidazol-2-yl)acetic acid

2-(1H-1H-benzo[d]iMidazol-2-yl)-acetic acid

2-(2-Benzoimidazolyl)acetic Acid

Benzimidazole-2-acetic acid

2-(1H-benzimidazol-2-yl)acetic acid

2-(1H-benzimidazol-2-yl)ethanoic acid

2-(1H-benzimidazol-3-ium-2-yl)acetate

2-(1H-benzimidazol-3-ium-2-yl)ethanoate

2-(Carboxymethyl)benzimidazole

2-BENZIMIDAZOLEACETIC ACID

Acetic acid, 2-benzimidazol-2-yl-

2-Benzimidazolylacetic acid

NSC 525202

1H-Benzimidazole-2-acetic acid (9CI, ACI)

13570-08-6

BENZIMIDAZOLE

Carboxylic Acids

Imidazoles & Benzimidazoles

Carboxylic Acids

Imidazoles & Benzimidazoles