(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
- Product Name
- (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
- CAS No.
- 13570-08-6
- Chemical Name
- (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID
- Synonyms
- NSC 525202;AKOS BBS-00002502;RARECHEM AK ML 0141;IFLAB-BB F1727-0259;CHEMBRDG-BB 4400292;2-BENZIMIDAZOLEACETIC ACID;Benzimidazole-2-acetic acid;2-Benzimidazolylacetic acid;1H-Benzimidazole-2-acetic acid;2-(Carboxymethyl)benzimidazole
- CBNumber
- CB5838729
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 13570-08-6.mol
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Property
- Melting point:
- 116 °C
- Boiling point:
- 498.3±28.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.54±0.30(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B130015
- Product name
- (1H-Benzoimidazol-2-yl)aceticAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB50783
- Product name
- (1H-Benzoimidazol-2-Yl)-Acetic Acid
- Packaging
- 100mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- FB50783
- Product name
- (1H-Benzoimidazol-2-Yl)-Acetic Acid
- Packaging
- 250mg
- Price
- $122.5
- Updated
- 2021/12/16
- Product number
- FB50783
- Product name
- (1H-Benzoimidazol-2-Yl)-Acetic Acid
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- X9925
- Product name
- (1H-benzoimidazol-2-yl)aceticacid
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Chemical Properties,Usage,Production
Uses
(1h-Benzoimidazol-2-yl)-acetic Acid is a useful intermediate for the synthesis of benzisothiazole/benzimidazole derivatives with acidic groups that exhibits numerous pharmacological properties.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 36, p. 1746, 1993 DOI: 10.1021/jm00064a008
Synthesis
4414-88-4
13570-08-6
General procedure for the synthesis of benzimidazole-2-acetic acid from 2-cyanomethylbenzimidazole: A mixture of 1 g of 2-cyanomethylbenzimidazole (3a-b) with 2 ml of 37% aqueous hydrochloric acid in the presence of 1 ml of benzenesulphonic acid was heated and stirred under reflux conditions for 4-5 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature and extracted with ether (3 x 30 ml), followed by removal of solvent by distillation under reduced pressure to afford the target products benzimidazole-2-acetic acid (4a-b). 4.3.1. 1H-benzimidazole-2-acetic acid (4a, C9H8N2O2) was a green solid, hygroscopic, with a yield of 81% and a melting point of 240-242 °C; TLC Rf value of 0.42 [unfolding reagent ratio of toluene: ethyl acetate: formic acid (5:4:1)]; IR spectra (KBr, cm^-1 ): 3624 (O-H telescoping vibration) 3230 (N-H stretching vibration), 1722 (C=O stretching vibration); 1H NMR (300MHz, DMSO-d6) δ (ppm): 3.64 (single peak, 2H, CH2COOH), 7.58 (double peaks, 2H, J=7.5,0.9Hz, H-5,6 on benzimidazole ring), 7.92 (double peaks, 2H, J=7.5 Hz, H-4,7 on the benzimidazole ring), 10.59 (broad peak, 1H, COOH), 12.03 (broad peak, 1H, NH).13C NMR (75 MHz, DMSO-d6) δ (ppm): 164.20, 152.20, 131.95, 128.32, 122.50, 48.40. Calculated values for elemental analysis (%) : C, 61.36; H, 4.58; N, 15.90; measured values (%): C, 61.33; H, 4.56; N, 15.92.
References
[1] Patent: US5792768, 1998, A
[2] Farmaco, 2002, vol. 57, # 5, p. 363 - 367
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 853 - 869
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 12, p. 1746 - 1753
[5] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 243
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID Suppliers
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View Lastest Price from (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID manufacturers
- Product
- (1H-benzoimidazol-2-yl)acetic acid 13570-08-6
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 1H-benzoimidazol-2-yl)acetic acid 13570-08-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- (1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID 13570-08-6
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12