ChemicalBook > CAS DataBase List > o-Toluic acid

o-Toluic acid

Product Name
o-Toluic acid
CAS No.
118-90-1
Chemical Name
o-Toluic acid
Synonyms
2-METHYLBENZOIC ACID;o-toluic;o-Totuic acid;ORTHO-TOLUIC ACID;uic acid;2-TOLUIC ACID;O-TOLUIC ACID;0-Toluic acid;O-TOLUYLIC ACID;o-ToluicAcid>
CBNumber
CB5852905
Molecular Formula
C8H8O2
Formula Weight
136.15
MOL File
118-90-1.mol
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o-Toluic acid Property

Melting point:
102-104 °C (lit.)
Boiling point:
258-259 °C (lit.)
Density 
1.062 g/mL at 25 °C (lit.)
refractive index 
1.512
Flash point:
148 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
1.2g/l
form 
Needle-Like Crystalline Solid
pka
3.91(at 25℃)
Specific Gravity
1.062
color 
White to slightly yellow
PH
3.1 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,9535
BRN 
1072103
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey
ZWLPBLYKEWSWPD-UHFFFAOYSA-N
CAS DataBase Reference
118-90-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-methyl-(118-90-1)
EPA Substance Registry System
o-Toluic acid (118-90-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-22
WGK Germany 
3
RTECS 
XU1400000
TSCA 
Yes
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T36404
Product name
o-Toluic acid
Purity
99%
Packaging
100g
Price
$63.1
Updated
2024/03/01
Sigma-Aldrich
Product number
T36404
Product name
o-Toluic acid
Purity
99%
Packaging
500g
Price
$121
Updated
2024/03/01
TCI Chemical
Product number
T0292
Product name
o-Toluic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$43
Updated
2024/03/01
TCI Chemical
Product number
T0292
Product name
o-Toluic Acid
Purity
>98.0%(T)
Packaging
100g
Price
$77
Updated
2024/03/01
Alfa Aesar
Product number
A13856
Product name
o-Toluic acid, 98+%
Packaging
250g
Price
$29.65
Updated
2024/03/01
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o-Toluic acid Chemical Properties,Usage,Production

Chemical Properties

White crystals. Slightly soluble in water; soluble in alcohol and chloroform. Combustible.

Uses

Bacteriostat.

Uses

o-Toluic acid is part of a group of Benzoic acid (B203900) derivatives that possess inhibitory activity against mushroom tyrosinases. o-Toluic acid is also used as a reagent to synthesize halogen-substituted benzoic acids (such as 2,4-Dichlorobenzoic acid [D431955]), which have potential muscle stimulating effects.

Definition

ChEBI: A methylbenzoic acid that is benzoic acid substituted by a methyl group at position 2.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 588, 1943
The Journal of Organic Chemistry, 25, p. 616, 1960 DOI: 10.1021/jo01074a035
Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7

Air & Water Reactions

Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.

Reactivity Profile

o-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in o-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. o-Toluic acid is incompatible with strong oxidizers.

Fire Hazard

Flash point data for o-Toluic acid are not available. o-Toluic acid is probably combustible. Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.

Purification Methods

Crystallise the acid from *benzene (2.5mL/g) and dry in air. The S-benzylisothiuronium salt has m 146o (from aqueous EtOH). [Beilstein 9 IV 1697.]

o-Toluic acid Preparation Products And Raw materials

Raw materials

o-Xylene Cobalt naphthenate

Preparation Products

Ethametsulfuron-methyl 2-BENZYL-2,3-DIHYDROISOQUINOLIN-4(1H)-ONE HYDROCHLORIDE 2-(Bromomethyl)benzoic acid Bensulfuron methyl Sulfometuron-methyl Tribenuron methyl o-Toluoyl chloride N-METHYL-N-(2-METHYLBENZYL)AMINE 2-METHYLBENZANILIDE Mepronil m-Cresol o-Tolunitrile METSULFURON METHYL
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View Lastest Price from o-Toluic acid manufacturers

Anhui Royal Chemical Co., Ltd.
Product
O-TOLUIC ACID 118-90-1
Price
US $100.00/KG
Min. Order
1000KG
Purity
99.5%
Supply Ability
20 TONS
Release date
2024-05-22
Hebei Weibang Biotechnology Co., Ltd
Product
o-Toluic acid 118-90-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-24
airuikechemical co., ltd.
Product
Ortho toluic acid 118-90-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

118-90-1, o-Toluic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Methyl 4-(bromomethyl)benzoate Methyl 4-methylbenzoate 4-HYDROXY-2-METHYLBENZOIC ACID 98 Methyl 2-(methylamino)benzoate 2-Iodobenzoic acid 2-Methoxybenzoic acid 2-Methyl-4-nitrobenzoic acid o-Tolunitrile 2-METHYL-6-NITROBENZOIC ACID 3-Methyl-4-nitrobenzoic acid Hyaluronic acid Citric acid Benzyl benzoate p-Toluic acid 3-Methyl-2-nitrobenzoic acid 2-Amino-5-methylbenzoic acid 3-Bromo-2-methylbenzoic acid

  • o-toluic
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  • Alogliptin Related Compound 46
  • 2-TOLUIC ACID
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  • AKOS BBS-00003722
  • METHYLBENZOIC(O-) ACID
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  • o-Methylbenzoate
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  • O-TOLUYLIC ACID
  • O-TOLUIC ACID
  • RARECHEM AL BO 0033
  • 2-Methylbenzoic Acid/o-Toluic acid
  • o-Totuic acid
  • O-ToluicAcidForSynthesis
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  • o-Toluic acid, 98+%
  • ORTHO-TOLUIC ACID FOR SYNTHESIS
  • o-Toluic acid118-90-1
  • 2-methylbenzoate
  • uic acid
  • [Carbonyl-14C1]-toluic acid
  • [Phenyl-U-14C6]-toluic acid
  • o-ToluicAcid&gt
  • Tolvaptan Impurity 52
  • OTA，o-Toluic acid
  • o-Toluic acid ISO 9001：2015 REACH
  • High Pharmaceutical O-Toluic Acid 2-Methylbenzoic Acid CAS?118-90-1
  • o-Toluic Acid pure, 99.5%
  • Ortho Toluic Acid (2-Methyl Benzoic Acid)
  • 0-Toluic acid
  • 118-90-1
  • 110-90-1
  • CH3C6H4COOH
  • 118901
  • Organic Building Blocks
  • ARYL ACID
  • Carbonyl Compounds
  • Carboxylic Acids
  • C8
  • Building Blocks
  • Pyrazines ,Pyrans
  • intermediates
  • Organic acids