4'-Methylacetophenone
- Product Name
- 4'-Methylacetophenone
- CAS No.
- 122-00-9
- Chemical Name
- 4'-Methylacetophenone
- Synonyms
- 4-METHYLACETOPHENONE;P-METHYLACETOPHENONE;FEMA 2677;P-ACETYLTOLUENE;4-ACETYLTOLUENE;1-p-tolyl-ethanone;4’-methyl-acetophenon;4-METHYLPHENACYL BROMIDE;1-(4-Methylphenyl)ethanone;Ethanone,1-(4-methylphenyl)-
- CBNumber
- CB5852945
- Molecular Formula
- C9H10O
- Formula Weight
- 134.18
- MOL File
- 122-00-9.mol
4'-Methylacetophenone Property
- Melting point:
- 22-24 °C (lit.)
- Boiling point:
- 226 °C (lit.)
- Density
- 1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)
- vapor pressure
- 0.52 hPa (25 °C)
- FEMA
- 2677 | 4'-METHYLACETOPHENONE
- refractive index
- n20/D 1.533(lit.)
- Flash point:
- 198 °F
- storage temp.
- Store below +30°C.
- solubility
- 2.07g/l
- form
- Liquid
- color
- Clear colorless to pale yellow
- Odor
- at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone
- Odor Type
- floral
- explosive limit
- 1.00%(V)
- Water Solubility
- 0.37 g/L (15 ºC)
- JECFA Number
- 807
- BRN
- 606053
- InChIKey
- GNKZMNRKLCTJAY-UHFFFAOYSA-N
- LogP
- 2.1 at 25℃
- CAS DataBase Reference
- 122-00-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(4-methylphenyl)-(122-00-9)
- EPA Substance Registry System
- Ethanone, 1-(4-methylphenyl)- (122-00-9)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22-20/21/22
- Safety Statements
- 26-27-37/39-24/25-23-36
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- RTECS
- AM9463000
- TSCA
- Yes
- HS Code
- 29143900
- Toxicity
- LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W267708
- Product name
- 4′-Methylacetophenone
- Purity
- ≥95%, FCC, FG
- Packaging
- 1kg
- Price
- $95.1
- Updated
- 2024/03/01
- Product number
- W267708
- Product name
- 4′-Methylacetophenone
- Purity
- ≥95%, FCC, FG
- Packaging
- 5kg
- Price
- $503
- Updated
- 2024/03/01
- Product number
- W267708
- Product name
- 4′-Methylacetophenone
- Purity
- ≥95%, FCC, FG
- Packaging
- 10Kg
- Price
- $601
- Updated
- 2024/03/01
- Product number
- W267708
- Product name
- 4′-Methylacetophenone
- Purity
- ≥95%, FCC, FG
- Packaging
- 25kg
- Price
- $1390
- Updated
- 2024/03/01
- Product number
- M26615
- Product name
- 4′-Methylacetophenone
- Purity
- 95%
- Packaging
- 100g
- Price
- $48.9
- Updated
- 2024/03/01
4'-Methylacetophenone Chemical Properties,Usage,Production
Description
4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared by slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.
Chemical Properties
4'-Methylacetophenone has been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone. 4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand hawthorn-type perfumes, especially soap perfumes.
Occurrence
Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry, celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry, mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked cabbage, mandarin juice.
Uses
4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.
Uses
4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics.
Preparation
By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.
Definition
ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.
Taste threshold values
Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like.
Synthesis Reference(s)
Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032
Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2
General Description
4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.
Safety Profile
Moderately toxic by ingestion. A human skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Purification Methods
Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]
4'-Methylacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-Methylacetophenone manufacturers
- Product
- 4'-Methylacetophenone 122-00-9
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- 4'-Methylacetophenone 122-00-9
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-03-26
- Product
- 4'-Methylacetophenone 122-00-9
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-14