ChemicalBook > CAS DataBase List > 4'-Methylacetophenone

4'-Methylacetophenone

Product Name
4'-Methylacetophenone
CAS No.
122-00-9
Chemical Name
4'-Methylacetophenone
Synonyms
4-METHYLACETOPHENONE;P-METHYLACETOPHENONE;FEMA 2677;P-ACETYLTOLUENE;4-ACETYLTOLUENE;1-p-tolyl-ethanone;4’-methyl-acetophenon;4-METHYLPHENACYL BROMIDE;1-(4-Methylphenyl)ethanone;Ethanone,1-(4-methylphenyl)-
CBNumber
CB5852945
Molecular Formula
C9H10O
Formula Weight
134.18
MOL File
122-00-9.mol
More
Less

4'-Methylacetophenone Property

Melting point:
22-24 °C (lit.)
Boiling point:
226 °C (lit.)
Density 
1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)
vapor pressure 
0.52 hPa (25 °C)
FEMA 
2677 | 4'-METHYLACETOPHENONE
refractive index 
n20/D 1.533(lit.)
Flash point:
198 °F
storage temp. 
Store below +30°C.
solubility 
2.07g/l
form 
Liquid
color 
Clear colorless to pale yellow
Odor
at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone
Odor Type
floral
biological source
synthetic
explosive limit
1.00%(V)
Water Solubility 
0.37 g/L (15 ºC)
JECFA Number
807
BRN 
606053
InChIKey
GNKZMNRKLCTJAY-UHFFFAOYSA-N
LogP
2.1 at 25℃
CAS DataBase Reference
122-00-9(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(4-methylphenyl)-(122-00-9)
EPA Substance Registry System
Ethanone, 1-(4-methylphenyl)- (122-00-9)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22-20/21/22
Safety Statements 
26-27-37/39-24/25-23-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
RTECS 
AM9463000
TSCA 
Yes
HS Code 
29143900
Toxicity
LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
1 unit
Price
$53.48
Updated
2025/07/31
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
1 unit
Price
$53.48
Updated
2025/07/31
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
1kg
Price
$98.1
Updated
2025/07/31
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
5kg
Price
$519
Updated
2025/07/31
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
10Kg
Price
$601
Updated
2025/07/31
More
Less

4'-Methylacetophenone Chemical Properties,Usage,Production

Description

4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared by slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Chemical Properties

4'-Methylacetophenone has been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone. 4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand hawthorn-type perfumes, especially soap perfumes.

Occurrence

Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry, celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry, mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked cabbage, mandarin juice.

Uses

4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.

Uses

4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics.

Preparation

By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Definition

ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.

Taste threshold values

Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like.

Synthesis Reference(s)

Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032
Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2

General Description

4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.

Safety Profile

Moderately toxic by ingestion. A human skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]

4'-Methylacetophenone Preparation Products And Raw materials

Raw materials

Benzyl chloride Acetyl chloride Aluminum chloride Semicarbazide

Preparation Products

4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE 4-Acetylbenzoic acid 5-P-TOLYL-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE 4-(1,2,3-THIADIAZOL-4-YL)BENZOYL CHLORIDE CYAZOFAMID ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE
More
Less

4'-Methylacetophenone Suppliers

Americas 1 Australia 2 Belgium 5 Canada 5 China 589 Europe 5 France 2 Germany 13 Hungary 1 India 80 Israel 1 Italy 1 Japan 10 Poland 1 Russia 1 Slovakia 1 Spain 2 Switzerland 3 The Netherlands 1 Ukraine 3 United Kingdom 18 United States 83 USA 1 Global 829
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Sam Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
samlab75@hotmail.com
Country
India
ProdList
7
Advantage
50
SREE SYNERIC LAB
Tel
--
Fax
--
Country
India
ProdList
328
Advantage
58
SANIKA CHEMICALS PVT.LTD.
Tel
--
Fax
--
Email
marketing@sanikachem.com
Country
India
ProdList
38
Advantage
58
Biosyn Research Chemicals
Tel
--
Fax
--
Email
info@biosyn.in
Country
India
ProdList
1340
Advantage
58
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
marketing@srlchem.com
Country
India
ProdList
4315
Advantage
58
Triveni chemicals
Tel
--
Fax
--
Email
sales@trivenichemical.com
Country
India
ProdList
6088
Advantage
58
K.V. Arochem Limited
Tel
--
Fax
--
Country
India
ProdList
53
Advantage
58
Clarion Organics Limited (Formerly Clarion Drugs Ltd)
Tel
--
Fax
--
Email
info@clariondrugs.com
Country
India
ProdList
37
Advantage
58
Shivam Pharma Chemicals
Tel
--
Fax
--
Email
info@shivampharma.com
Country
India
ProdList
656
Advantage
58
Aroma Sales Corporation
Tel
--
Fax
--
Country
India
ProdList
131
Advantage
58
S H Kelkar and Company Limited
Tel
--
Fax
--
Email
marketing@keva.co.in
Country
India
ProdList
62
Advantage
58
Sam Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
karan@samlaboratories.com
Country
India
ProdList
10
Advantage
58
Shriya Chemicals Pvt., Ltd.
Tel
--
Fax
--
Email
info@shriyachemicals.com
Country
India
ProdList
6
Advantage
58
HiMedia Laboratories
Tel
--
Fax
--
Email
o@himedialabs.com
Country
India
ProdList
1841
Advantage
58
Chemplast Sanmar Limited
Tel
--
Fax
--
Country
India
ProdList
48
Advantage
58
SPB Pharma Chiemimpex
Tel
--
Fax
--
Email
sales@spbpharmachem.com
Country
India
ProdList
94
Advantage
58
Neuchatel Chemie Specialties
Tel
--
Fax
--
Country
India
ProdList
54
Advantage
58
Chiral Chemicals
Tel
--
Fax
--
Email
chiral@chiralchemical.com
Country
India
ProdList
142
Advantage
58
Labort Fine Chem Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
76
Advantage
58
Chemrich Fine Chemicals Private Limited
Tel
--
Fax
--
Country
India
ProdList
53
Advantage
58
Ramsun Bio Organics (formerly Ramsun Rasayanics)
Tel
--
Fax
--
Email
info@ramsun.co.in
Country
India
ProdList
24
Advantage
58
Benzo Chem Industries Pvt. Ltd
Tel
--
Fax
--
Country
India
ProdList
83
Advantage
58
SL Drugs & Pharmaceuticals
Tel
--
Fax
--
Country
India
ProdList
72
Advantage
58
Avigya Biosciences Pvt., Ltd.
Tel
--
Fax
--
Email
info@avigyabio.com
Country
India
ProdList
115
Advantage
58
Synergy United Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
info@synergyunited.in
Country
India
ProdList
27
Advantage
58
Oceanic Pharmachem Pvt., Ltd. (OPPL)
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
946
Advantage
58
Mithila Drugs Private Limited
Tel
--
Fax
--
Country
India
ProdList
3
Advantage
58
Trignokem International.
Tel
--
Fax
--
Email
ignokem@gmail.com
Country
India
ProdList
233
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Universal Aromatic
Tel
--
Fax
--
Email
info@universalaromatic.com
Country
India
ProdList
14
Advantage
58
Gliesse Pharmaceuticals Pvt., Ltd.
Tel
--
Fax
--
Email
info@gliessepharma.com
Country
India
ProdList
165
Advantage
58
Innovative Synthetic Molecules
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Sodium Metal Pvt., Ltd.
Tel
--
Fax
--
Email
kasture@smfinechem.in
Country
India
ProdList
16
Advantage
58
Kevy's Labs
Tel
--
Fax
--
Email
kevyslabs@rocketmail.com
Country
India
ProdList
29
Advantage
58
Cameo Health Care (India) Private Limited
Tel
--
Fax
--
Country
India
ProdList
47
Advantage
58
Swadev Chemicals
Tel
--
Fax
--
Email
info@swadevchemicals.com
Country
India
ProdList
19
Advantage
58
Pratap Organics Pvt. Ltd.
Tel
--
Fax
--
Country
India
ProdList
87
Advantage
58
Krystal Tech
Tel
--
Fax
--
Country
India
ProdList
102
Advantage
58
Anand Agencies
Tel
--
Fax
--
Email
en@gmail.com
Country
India
ProdList
2332
Advantage
58
Benzo Chem Industries Private Limited
Tel
--
Fax
--
Country
India
ProdList
25
Advantage
58
P.C. Chem India
Tel
--
Fax
--
Country
India
ProdList
134
Advantage
58
SD Intermediates
Tel
--
Fax
--
Country
India
ProdList
11
Advantage
58
Seema Biotech
Tel
--
Fax
--
Country
India
ProdList
32
Advantage
58
Sriven Pharmachem India Private Limited
Tel
--
Fax
--
Country
India
ProdList
25
Advantage
58
Ganesh Chem tech Pvt Ltd
Tel
--
Fax
--
Country
India
ProdList
44
Advantage
58
Sanika Chemicals Pvt. Ltd.
Tel
--
Fax
--
Country
India
ProdList
26
Advantage
58
Jainam Traders
Tel
--
Fax
--
Country
India
ProdList
24
Advantage
58
More
Less

View Lastest Price from 4'-Methylacetophenone manufacturers

RongNa Biotechnology Co.,Ltd
Product
4'-Methylacetophenone 122-00-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 ton
Release date
2025-05-04
Speranza Chemical Co., Ltd.
Product
4'-Methylacetophenone 122-00-9
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300 Tons/ year
Release date
2019-12-25
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4'-Methylacetophenone 122-00-9
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-14

122-00-9, 4'-MethylacetophenoneRelated Search:

4-Aminoacetophenone 4-Nitroacetophenone 4'-Hydroxyacetophenone 4'-Methoxyacetophenone 4-Methylbenzyl cyanide Methyl salicylate Acetophenone 3'-(Trifluoromethyl)acetophenone Chalcone Kresoxim-methyl 4-Methylphenylacetic acid 4'-Chloroacetophenone Tribenuron methyl 4'-Bromoacetophenone METSULFURON METHYL Thiophanate-methyl Benzene 4,4'-Dichlorobenzophenone

  • Acetophenone, 4'-methyl-
  • Esberiven
  • Ethanone,1-(4-methylphenyl)-
  • Melilot
  • Melilotal
  • p-Acetotoluene
  • Sweet clover
  • Yellow melilot
  • Yellow sweet clover
  • 1-p-tolyl-ethanone
  • 4’-methyl-acetophenon
  • 4-METHYLACETOPHENONE 97+%
  • 4-Methyacetophenone
  • p-METHYLACETOPHENONE technical
  • 4-Met-17Iyl acetopllenone
  • p-Tolyl methyl ketone
  • Methyl 4-methylphenyl ketone
  • METHYLACETOPHENONE, 4-(SG)
  • 4′-Methylacetophenone ,98%
  • 4′-Methylacetophenone,Methyl p-tolyl ketone
  • 4-Methylacetophenone, synthesis grade
  • 1-(4-Methylphenyl)-1-ethanone
  • 1-(4-Tolyl)ethanone
  • 4-Methyl-1-acetylbenzene
  • 4'-Methylacetophen
  • 4-Methylhypnone
  • The Methyl acetophenone
  • 4'-Methylacetophenone Vetec(TM) reagent grade, 94%
  • 4'-Methylacetophenone,95%
  • P-ACETYLTOLUENE
  • P-METHYLACETOPHENONE
  • (4-Methylphenyl) methyl ketone
  • 1-(4-methylphenyl)-ethanon
  • 1-(4-Methylphenyl)ethanone
  • 1-(4-methyl-phenyl)-ethanone
  • 1-(4-methylphenyl)-Ethanone
  • 1-(4-Methylpheyl)ethanone
  • FEMA 2677
  • BUTTPARK 41\03-57
  • METHYL P-TOLYL KETONE
  • 1-(4-METHYLPHENYL)ETHAN-1-ONE
  • 1-acetyl-4-methyl benzene
  • 1-METHYL-4-ACETYLBENZENE
  • 2-BROMO-1-(4-METHYLPHENYL)-1-ETHANONE
  • 2-BROMO-1-(4-METHYLPHENYL)ETHANONE
  • AKOS BBS-00003271
  • AKOS BBS-00000936
  • 4-(BROMOACETYL)TOLUENE
  • 4-ACETYLTOLUENE
  • 4-METHYLACETOPHENONE
  • (4-METHYLPHENYL)ETHANONE
  • 4-METHYLPHENACYL BROMIDE
  • METHYLACETOPHENONE-4
  • METHYL 4-TOLYL KETONE
  • 1-Methyl-4-acetylbenzen
  • 4-Methylacetophenone (p-)
  • p-methylphenyl methyl ketone
  • 4'-Methylacetophenone 4-Acetyltoluene 4-Methylacetophenone