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4'-Methylacetophenone

Product Name
4'-Methylacetophenone
CAS No.
122-00-9
Chemical Name
4'-Methylacetophenone
Synonyms
4-METHYLACETOPHENONE;P-METHYLACETOPHENONE;FEMA 2677;P-ACETYLTOLUENE;4-ACETYLTOLUENE;1-p-tolyl-ethanone;4’-methyl-acetophenon;4-METHYLPHENACYL BROMIDE;1-(4-Methylphenyl)ethanone;Ethanone,1-(4-methylphenyl)-
CBNumber
CB5852945
Molecular Formula
C9H10O
Formula Weight
134.18
MOL File
122-00-9.mol
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4'-Methylacetophenone Property

Melting point:
22-24 °C (lit.)
Boiling point:
226 °C (lit.)
Density 
1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)
vapor pressure 
0.52 hPa (25 °C)
FEMA 
2677 | 4'-METHYLACETOPHENONE
refractive index 
n20/D 1.533(lit.)
Flash point:
198 °F
storage temp. 
Store below +30°C.
solubility 
2.07g/l
form 
Liquid
color 
Clear colorless to pale yellow
Odor
at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone
Odor Type
floral
explosive limit
1.00%(V)
Water Solubility 
0.37 g/L (15 ºC)
JECFA Number
807
BRN 
606053
InChIKey
GNKZMNRKLCTJAY-UHFFFAOYSA-N
LogP
2.1 at 25℃
CAS DataBase Reference
122-00-9(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(4-methylphenyl)-(122-00-9)
EPA Substance Registry System
Ethanone, 1-(4-methylphenyl)- (122-00-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22-20/21/22
Safety Statements 
26-27-37/39-24/25-23-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
RTECS 
AM9463000
TSCA 
Yes
HS Code 
29143900
Toxicity
LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
1kg
Price
$95.1
Updated
2024/03/01
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
5kg
Price
$503
Updated
2024/03/01
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
10Kg
Price
$601
Updated
2024/03/01
Sigma-Aldrich
Product number
W267708
Product name
4′-Methylacetophenone
Purity
≥95%, FCC, FG
Packaging
25kg
Price
$1390
Updated
2024/03/01
Sigma-Aldrich
Product number
M26615
Product name
4′-Methylacetophenone
Purity
95%
Packaging
100g
Price
$48.9
Updated
2024/03/01
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4'-Methylacetophenone Chemical Properties,Usage,Production

Description

4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared by slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Chemical Properties

4'-Methylacetophenone has been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone. 4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand hawthorn-type perfumes, especially soap perfumes.

Occurrence

Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry, celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry, mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked cabbage, mandarin juice.

Uses

4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.

Uses

4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics.

Preparation

By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Definition

ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.

Taste threshold values

Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like.

Synthesis Reference(s)

Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032
Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2

General Description

4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.

Safety Profile

Moderately toxic by ingestion. A human skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]

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4'-Methylacetophenone Suppliers

TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23680
Advantage
75
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View Lastest Price from 4'-Methylacetophenone manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
4'-Methylacetophenone 122-00-9
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-25
Shandong Hanjiang Chemical Co., Ltd
Product
4'-Methylacetophenone 122-00-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-19
Dorne Chemical Technology co. LTD
Product
4'-Methylacetophenone 122-00-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 ton
Release date
2024-03-26

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