N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

Product Name: N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
CAS No.: 1715-30-6
Chemical Name: N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
Synonyms: QR-711;WIN-21904;Bisguadine;Sterwin 904;Compound-904;Bisguanidine;Alexidine Dihydrochloride extrapure, 96%;1,1'-Hexamethylenebis[5-(2-ethylhex-1-yl)]biguanide dihydrochloride;1,1'-Hexamethylenebis(5-(2-ethylhex-1-yl))biguanide dihydrochloride;N,N''-Bis(2-ethylhexyl)-3,12-diiMino-2,4,11,13-tetraazatetradecanediiMidaMide
CBNumber: CB5902570
Molecular Formula: C26H58Cl2N10
Formula Weight: 581.71172
MOL File: 1715-30-6.mol

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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Property

Melting point:: 220.6-223.4°C
storage temp.: -20°C
solubility: DMSO: ≥10mg/mL
form: powder
color: white to off-white
Stability:: Hygroscopic
EPA Substance Registry System: 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride (1715-30-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2925290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8986
Product name: Alexidine dihydrochloride
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $84.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8986
Product name: Alexidine dihydrochloride
Purity: ≥95% (HPLC)
Packaging: 50mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 13876
Product name: Alexidine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 13876
Product name: Alexidine (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 13876
Product name: Alexidine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $100
Updated: 2024/03/01

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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Powder with Light Yellow Cast

Uses

Has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.

Uses

Alexidine dihydrochloride has been used:

as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms
as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8⁺ T cells
as a PTPMT1 inhibitor to study its antiviral effect on ?human cytomegalovirus?(HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells

Biological Activity

selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (ptpmt1) (ic50 = 1.08 μm in vitro). stimulates increased insulin secretion by β-cells in rat pancreatic islets. displays antitcancer properties in fadu cells.

Biochem/physiol Actions

Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.

storage

Desiccate at -20°C

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride Suppliers

Canada 1 China 46 Europe 1 India 2 Japan 1 United Kingdom 2 United States 10 USA 1 Global 64

AdooQ BioScience, LLC

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1715-30-6, N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochlorideRelated Search:

Trimethylamine hydrochloride Methylamine hydrochloride L-Lysine hydrochloride Betaine hydrochloride Dimethylamine hydrochloride

Bisguanidine

N,N''-Bis(2-ethylhexyl)-3,12-diiMino-2,4,11,13-tetraazatetradecanediiMidaMide

Sterwin 904

1,1'-Hexamethylenebis[5-(2-ethylhex-1-yl)]biguanide dihydrochloride

Alexidine dihydrochloride, N,N''''-Hexane-1,6-diylbis[N'-(2-ethylhex-1-yl)(imidodicarbonimidic diamide)] dihydrochloride

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

Bisguadine

Compound-904

QR-711

WIN-21904

N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamidedihydrochloride

Alexidine Dihydrochloride extrapure, 96%

anticancer,antibiofilm,Fungal,mitochondrial,AXD,antifungal,phosphatase,Alexidine dihydrochloride,tyrosine,inhibit,PTPMT1,Apoptosis,Inhibitor,Alexidine

N,N''-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride

N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-Tetraazatetradecanediimidamide dihydrochloride

1,1'-Hexamethylenebis(5-(2-ethylhex-1-yl))biguanide dihydrochloride

1715-30-6

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Isotope Labelled Compounds