4-(Trifluoromethyl)benzamide

Product Name: 4-(Trifluoromethyl)benzamide
CAS No.: 1891-90-3
Chemical Name: 4-(Trifluoromethyl)benzamide
Synonyms: TIMTEC-BB SBB002331;p-Trifluoromethylbenzamide;4-Carbamoylbenzotrifluoride;à,à,à-trifluoro-p-toluamide;4-(TRIFLUOROMETHYL)BENZAMIDE;N-(4-Trifluoromethyl)benzamide;4-(Trifluoromethyl)benzamide99%;Benzamide, 4-(trifluoromethyl)-;4-(TRIFLUOROMETHYL)BENZAMIDE 99%;4-(Trifluoromethyl)benzamide, 98+%
CBNumber: CB6105480
Molecular Formula: C8H6F3NO
Formula Weight: 189.13
MOL File: 1891-90-3.mol

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4-(Trifluoromethyl)benzamide Property

Melting point:: 184-186 °C(lit.)
Boiling point:: 254.2±40.0 °C(Predicted)
Density: 1.3305 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 15.36±0.50(Predicted)
color: White to Almost white
BRN: 2098929
CAS DataBase Reference: 1891-90-3(CAS DataBase Reference)
NIST Chemistry Reference: 4-CF3-C6H4CONH2(1891-90-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3474
Product name: 4-(Trifluoromethyl)benzamide
Packaging: 5G
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: T3474
Product name: 4-(Trifluoromethyl)benzamide
Packaging: 25G
Price: $151
Updated: 2025/07/31

TRC

Product number: T797033
Product name: 4-(Trifluoromethyl)benzamide
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 005390
Product name: 4-(Trifluoromethyl)benzamide
Purity: 99%
Packaging: 25g
Price: $62
Updated: 2021/12/16

Apolloscientific

Product number: PC7507
Product name: 4-(Trifluoromethyl)benzamide
Purity: 99%
Packaging: 25g
Price: $44
Updated: 2021/12/16

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4-(Trifluoromethyl)benzamide Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Synthesis

329-15-7

1891-90-3

Synthesis of compound C: Ammonia (2 mL) was slowly added dropwise to 4-trifluoromethylbenzoyl chloride (417 mg, 2 mmol) at room temperature while maintaining stirring. After the reaction continued for 3 h, the completion of the reaction was confirmed by thin layer chromatography (TLC, unfolding agent ratio of ethyl acetate:hexane = 1:2). The reaction mixture was poured into water (10 mL) and subsequently extracted with ethyl acetate (10 mL x 3). The combined ethyl acetate layers were washed sequentially with water (10 mL × 2) and saturated saline (10 mL), dried over anhydrous magnesium sulfate and filtered. The filtrate was distilled under reduced pressure to remove the solvent to give the crude product (355 mg, 2.0 mmol). The crude product was purified by solvent recrystallization from ethyl acetate/hexane mixture to give compound C (white needle-like crystals, 359 mg) in 95% yield. The melting point of the product was 186.5-187.5 °C. 1H-NMR (300 MHz, DMSO-d6) δ: 7.63, 8.19 (both broad peaks, 1H, NH or OH), 8.06 (double peak, 2H, J = 8.0 Hz, Ar-H), 7.84 (double peak, 2H, J = 8.0 Hz, Ar-H).

References

[1] Organic Process Research and Development, 2007, vol. 11, # 6, p. 1010 - 1014
[2] Patent: EP2070908, 2009, A1. Location in patent: Page/Page column 9; 13
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 8, p. 2400 - 2411
[4] Synthetic Communications, 2010, vol. 40, # 23, p. 3538 - 3543
[5] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1957, vol. 23, p. 634

4-(Trifluoromethyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethyl)benzamide Suppliers

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View Lastest Price from 4-(Trifluoromethyl)benzamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Trifluoromethyl)benzamide 1891-90-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yanxi Chemical Co., Ltd.

Product: 4-(Trifluoromethyl)benzamide 1891-90-3
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-20

Career Henan Chemical Co

Product: 4-(Trifluoromethyl)benzamide 1891-90-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-04

1891-90-3, 4-(Trifluoromethyl)benzamideRelated Search:

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Benzamide, 4-(trifluoromethyl)-

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p-Trifluoromethylbenzamide

4-(TRIFLUOROMETHYL)BENZAMIDE

TIMTEC-BB SBB002331

4-(Trifluoromethyl)Benzamide p-(Trifluoromethyl)Benzamide

4-(TRIFLUOROMETHYL)BENZAMIDE 99%

4-(Trifluoromethyl)benzamide, 98+%

à,à,à-trifluoro-p-toluamide

4-(Trifluoromethyl)benzamide99%

4-Carbamoylbenzotrifluoride

1891-90-3

CF3C6H4CONH2

C8H6NOF3

C8H6F3NO

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